Bacterial prostatitis
is a common disease of the male
genitourinary
system, which seriously affects the normal life and health of male
patients. Antibiotics are commonly used in the clinical treatment
of bacterial prostatitis, but the efficacy of fluoroquinolones is
gradually declining due to the increasing drug resistance of bacteria.
Hence, it is necessary to find new antibacterial drugs to treat bacterial
prostatitis. Luteolin is a natural flavonoid compound with many pharmacological
activities such as antibacterial and anti-inflammatory activities,
but its poor water solubility and low structural stability seriously
limit its clinical application. In this study, we designed a targeting
drug delivery system via a luteolin–copper complex grafted
with hyaluronic acid. The results of the characterization proved the
successful synthesis of the system. The results of the in vitro performance
test show that the system has a good antibacterial effect and excellent
blood compatibility and can be effectively released under different
pH conditions. The prepared nanodrug delivery system not only provides
a new idea for the treatment of bacterial prostatitis but also lays
a theoretical and practical foundation for the wide application of
luteolin in clinical practice.