Polyglycerol fatty acid ester contributes to the improvement and maintenance of water solubility of amorphous curcumin by suppressing the intermolecular interaction and the diffusion rate of curcumin

Nagano, Kazuya; Nakao, Tomohiro; Takeda, Mariko; Hirai, Haruna; Maekita, Hikaru; Nakamura, Michiko; Imakawa, Naoki; Egawa, Ayako; Fujiwara, Toshimichi; Gao, Jian-Qing; Kinoshita, Keigo; Sakata, Makoto; Nishino, Masayuki; Yamashita, Takuya; Yoshida, Takuya; Harada, Kazuo; Tachibana, Keisuke; Doi, Takefumi; Hirata, Kazumasa; Tsujino, Hirofumi; Higashisaka, Kazuma; Tsutsumi, Yasuo

doi:10.1016/j.foodchem.2023.137866

Cited by 2 publications

(2 citation statements)

References 40 publications

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“…Here are some speculations about the mechanism for extraction. Structurally, quercetin has simple structures with two or more phenolic hydroxyl groups, while nuciferine possesses a tetracyclic core with a nitrogen atom and one chiral center. , The extracts with Tween 80 and glyceryl contribute to the good water solubility aspects of nuciferine and quercetin by suppressing the intermolecular interactions . In the meantime, enzyme and ultrasound-assisted extraction of the solvent could be effective, which breaks the cell wall of the lotus leaf and stimulates the extraction of target compounds …”

Section: Resultsmentioning

confidence: 99%

“…9,53 The extracts with Tween 80 and glyceryl contribute to the good water solubility aspects of nuciferine and quercetin by suppressing the intermolecular interactions. 54 In the meantime, enzyme and ultrasound-assisted extraction of the solvent could be effective, which breaks the cell wall of the lotus leaf and stimulates the extraction of target compounds. 55 Microstructural Characterization by a Scanning Electron Microscope.…”

Section: Effect Of Different Enzymes On the Extraction Rate Ofmentioning

confidence: 99%

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Enzyme-Assisted Extraction of Nuciferine and Quercetin from Lotus Leaves Using the Aqueous-Based Method: A Sustainable Approach

Liu,

Yan

et al. 2023

ACS Sustainable Chem. Eng.

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Section: Resultsmentioning

confidence: 99%

Section: Effect Of Different Enzymes On the Extraction Rate Ofmentioning

confidence: 99%

Enzyme-Assisted Extraction of Nuciferine and Quercetin from Lotus Leaves Using the Aqueous-Based Method: A Sustainable Approach

Liu,

Yan

et al. 2023

ACS Sustainable Chem. Eng.

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Hyaluronic Acid-Modified Luteolin–Copper Complex Nanodelivery System for Bacterial Prostatitis

Li,

Zheng,

et al. 2024

ACS Omega

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Bacterial prostatitis is a common disease of the male genitourinary system, which seriously affects the normal life and health of male patients. Antibiotics are commonly used in the clinical treatment of bacterial prostatitis, but the efficacy of fluoroquinolones is gradually declining due to the increasing drug resistance of bacteria. Hence, it is necessary to find new antibacterial drugs to treat bacterial prostatitis. Luteolin is a natural flavonoid compound with many pharmacological activities such as antibacterial and anti-inflammatory activities, but its poor water solubility and low structural stability seriously limit its clinical application. In this study, we designed a targeting drug delivery system via a luteolin–copper complex grafted with hyaluronic acid. The results of the characterization proved the successful synthesis of the system. The results of the in vitro performance test show that the system has a good antibacterial effect and excellent blood compatibility and can be effectively released under different pH conditions. The prepared nanodrug delivery system not only provides a new idea for the treatment of bacterial prostatitis but also lays a theoretical and practical foundation for the wide application of luteolin in clinical practice.

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Polyglycerol fatty acid ester contributes to the improvement and maintenance of water solubility of amorphous curcumin by suppressing the intermolecular interaction and the diffusion rate of curcumin

Cited by 2 publications

References 40 publications

Enzyme-Assisted Extraction of Nuciferine and Quercetin from Lotus Leaves Using the Aqueous-Based Method: A Sustainable Approach

Enzyme-Assisted Extraction of Nuciferine and Quercetin from Lotus Leaves Using the Aqueous-Based Method: A Sustainable Approach

Hyaluronic Acid-Modified Luteolin–Copper Complex Nanodelivery System for Bacterial Prostatitis

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