Polygenic variability in chromosomes of Drosophila melanogaster obtained from the wild

Harrison, B J; Mather, Kenneth

doi:10.1038/hdy.1950.23

Cited by 12 publications

(6 citation statements)

References 7 publications

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“…This was reflected in a decrease in the number of ascospores produced, an increase in the number of aborted ascospores and asci, and a decrease in the number of mature perithecia produced. This decrease in fertility is similar to that obtained by selecting for differences in bristle number in Drosophila melanogaster (Mather and Wigan 1942;Harrisson and Mather 1950) and can probably be regarded as a correlated response. The mass culture lines set up to try to improve the fertility of the low line gave an increase in fertility, yet no significant drop in mean ascospore length.…”

Section: Discussionsupporting

confidence: 62%

Studies Concerning the Inheritance of Ascospore Length in Neurospora Crassa I. Studies on Large-Spored Stra,Ins

Lee¹,

Pateman²

1961

Aust. Jnl. Of Bio. Sci.

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SummaryPrevious work has shown that the inheritance of ascospore size in certain strains of Neurospora crassa is controlled by a polygenic system with a small cytoplasmic component. Various types of selection lines were set up in strains that had been selected for the large· spored character. The results of these selection procedures are discussed. Experimental work which gives a better estimate of the linkage of part of this polygenic system to the albino locus on chromosome I is reported.

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Section: Discussionsupporting

confidence: 62%

Studies Concerning the Inheritance of Ascospore Length in Neurospora Crassa I. Studies on Large-Spored Stra,Ins

Lee¹,

Pateman²

1961

Aust. Jnl. Of Bio. Sci.

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“…Sex difference has already been shown to vary with slight genetic alterations (Harrison and Mather, 1950), but never to the extent of that shown by the LM lines ( fig. 3).…”

Section: Sex Differences In Chaeta Numbermentioning

confidence: 99%

Reversal of a secondary sex character by selection

Harrison

1953

Heredity

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“…The recombinants, being more extreme, were favoured in his high and low selection lines. Harrison & Mather (1950) showed that variability is essential for a response to selection, since little or no response occurred in homozygotes, but considerable response occurred in heterozygotes presumably because of recombination and rearrangement of polygenic combinations.…”

Section: Experimental Evidence For Polygenic Balance ( I ) Introductionmentioning

confidence: 99%

Selection, Prediction and Response

Lee

Parsons

1968

Biological Reviews

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Summary 1. The biometric approach to selection experiments has been outlined, and found to be rather deficient because it is based on excessively restrictive models which cannot take into account the complex architectures of quantitative traits as are being revealed today. 2. The nature of polygenes is discussed in detail from the theoretical point of view. In out breeding species, some form of the balanced polygenic complex is likely, showing polymorphism for the constituent genes. Although polymorphism is implicit in the argument, definitive evidence for poiymorphisms has only just appeared. 3. There is no evidence that polygenes differ from any other gene. 4. Several artificial selection experiments are described, in particular in Drosophila. By means of appropriate breeding techniques after obtaining responses to selection, genetic activity controlling quantitative traits can be located to chromosomes, and even specific loci found. Such few studies as have been carried out reveal, in general, the types of genetic architecture predicted on theoretical grounds. 5. Selection for behavioural traits is considered briefly and it appears that no new principles are needed, except that careful environmental control and objective measurement present problems. 6. The results of selection for quantitative traits in micro‐organisms reveal similarities to results in higher organisms in the few cases where definitive work has been carried out. 7. Work on the simulation of models by computers has not greatly advanced selection experiment theory, mainly because, with few exceptions, linkage has been ignored. 8. The existing theory on which selection experiments are based is inadequate for several reasons. It cannot predict the rate of response to selection nor the ultimate limits to selection, the nature of correlated responses to selection, nor the nature of gene segregation underlying the observed variability. 9. Strains set up from single inseminated founder females from the same population of Drosophila have been shown to differ genetically for several quantitative traits. Therefore the base population is polymorphic for genes controlling these traits. This was exploited by carrying out directional selection on lines derived from those strains showing a high incidence of scutellar chaetae. This led to far more rapid responses to selection than lines derived from strains where the incidence of scutellar chaetae was lower. 10. Ultimately, one can envisage the selection experiment as it is known today being partly replaced by the manipulation of located genes controlling quantitative traits into certain combinations.

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Polygenic variability in chromosomes of Drosophila melanogaster obtained from the wild

Cited by 12 publications

References 7 publications

Studies Concerning the Inheritance of Ascospore Length in Neurospora Crassa I. Studies on Large-Spored Stra,Ins

Studies Concerning the Inheritance of Ascospore Length in Neurospora Crassa I. Studies on Large-Spored Stra,Ins

Reversal of a secondary sex character by selection

Selection, Prediction and Response

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