Polygenic scores for schizophrenia and educational attainment are associated with behavioural problems in early childhood in the general population

Jansen, Philip R.; Polderman, Tinca J. C.; Bolhuis, Koen; Ende, Jan van der; Jaddoe, Vincent W. V.; Verhulst, Frank C.; White, Tonya; Posthuma, Daniëlle

doi:10.1111/jcpp.12759

Cited by 75 publications

(96 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To our knowledge, only one other study has examined whether genetic risk for BD is associated with childhood psychopathology. Using data from the Generation R cohort, the authors reported the BD-PRS (using the PGC-1-BD GWAS summary statistics) was not associated with externalising or internalising scales on the Child Behaviour Checklist (CBCL) in children at ages 3, 6 and 10 years (Jansen et al, 2018). Our study, though the first to examine the association of childhood psychopathology with the most recent PGC-2-GWAS of BD is consistent with these findings.…”

Section: Bd-prs and Sdqmentioning

confidence: 99%

Genetic risk for bipolar disorder and psychopathology from childhood to early adulthood

Mistry

Escott‐Price

Florio

et al. 2019

Journal of Affective Disorders

View full text Add to dashboard Cite

Background Studying the phenotypic manifestations of increased genetic liability for Bipolar Disorder (BD) can increase understanding of this disorder. Aims We assessed whether genetic risk for BD was associated with childhood psychopathology and features of hypomania in young adulthood within a large population-based birth cohort. Methods We used data from the second Psychiatric Genetics Consortium Genome Wide Association Study (GWAS) for Bipolar Disorder to construct a polygenic risk score (PRS) for each individual in the Avon Longitudinal Study of Parents and Children (ALSPAC). Linear and logistic regression models were used to assess associations between the BD-PRS and emotional/behavioural difficulties, attention deficit hyperactivity disorder (ADHD) and borderline personality disorder (BPD) traits in childhood, as well as hypomania in early adulthood (sample sizes from 2,654 to 6,111). Results The BD-PRS was not associated with total hypomania score, but was weakly associated with a binary measure of hypomania (OR=1.13, 95%CI 0.98,1.32; p=0.097), and particularly at higher hypomania symptom thresholds (strongest evidence OR=1.33, 95%CI 1.07, 1.65; p=0.01). The BD-PRS was also associated with ADHD (OR=1.31, 95%CI 1.10, 1.57; p=0.018), but not with other childhood psychopathology. 3 Limitations The PRS only captures common genetic variation and currently explains a relatively small proportion of the variance for BD. Conclusions The BD-PRS was associated with ADHD in childhood, and weakly with adult hypomania, but not with other psychopathology examined. Our findings suggest that genetic risk for BD does not appear to manifest in childhood to the same extent as schizophrenia genetic risk has been reported to do.

show abstract

Section: Bd-prs and Sdqmentioning

confidence: 99%

Genetic risk for bipolar disorder and psychopathology from childhood to early adulthood

Mistry

Escott‐Price

Florio

et al. 2019

Journal of Affective Disorders

View full text Add to dashboard Cite

show abstract

“…In this perspective, Jansen et al. (), in this Journal, conducted a synoptic multiple PRS study in the general population. Concretely, they investigated whether six PRS of later life outcomes (i.e., five psychiatric disorders – namely schizophrenia, attention‐deficit hyperactivity disorder, bipolar disorder, major depressive disorder, and autism spectrum disorder – and educational attainment), were associated with early childhood psycho‐behavioral problems.…”

mentioning

confidence: 99%

“…These results should provide us with important clues regarding the neurodevelopmental antecedents of schizophrenia. Indeed, despite contingent differences in experimental setting and design (e.g., target ages, main (endo)phenotypic outcomes and assessment tools), studies conducted in the general population (e.g., Jansen et al., ; Riglin et al., ) allow nontrivial preliminary considerations on the phenotypic effects of schizophrenia PRS.…”

mentioning

confidence: 99%

“…First, focusing on the developmental timing, phenotypic effects of schizophrenia PRS are early, substantial, and detectable at a behavioral level by infancy (age 3: Jansen et al., ; age 4: Riglin et al., ).…”

mentioning

confidence: 99%

“…Studies like the one by Jansen et al. () could help disentangling the respective contribution of genetic and environmental risk factors along neurodevelopmental stages (e.g., perinatal period, infancy, childhood, preadolescence, adolescence, young‐adulthood, adulthood). This could certainly amplify the resolution of the clinical staging model, which segments the progression toward psychosis into five phases (i.e., premorbid, early prodromal, late prodromal, clinical, and chronic) and is currently at the heart of contemporary early detection and intervention programs (McGorry, ; See Figure ).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Editorial Perspective: From schizophrenia polygenic risk score to vulnerability (endo‐)phenotypes: translational pathways in child and adolescent mental health

Poletti

Raballo

2018

Child Psychology Psychiatry

View full text Add to dashboard Cite

The Polygenic Risk Scores (PRS) approach is becoming increasingly prominent in psycho-behavioral research, however, its translational potential is still relatively underconceptualized. Indeed, PRS paradigm (which capitalizes on the combination of multiple genetic markers into a single proxy score to predict lifetime outcomes) has the potential to unravel some of the developmental complexities leading to severe mental disorders. With respect to schizophrenia, the application of PRS approach to child-adolescent cohorts from the general population, provides a crucial vantage point for understanding how presumed genetic predisposition is manifested during developmental years. Clearly, this is essential for etiological research as well as for the timely identification of the earliest stages of those specific psychopathological trajectories leading to psychosis. Therefore, the translational import of the PRS approach could improve our etiopathogenetic understanding of schizophrenia (e.g., allowing the disentanglement of the respective contribution of genetic and environmental risk factors along neurodevelopment) and further refine current staging models for early detection of vulnerability to psychosis (e.g., providing the rationale for more developmentally oriented reformulations of clinical high-risk criteria).

show abstract

Association of Genetic Risk for Schizophrenia and Bipolar Disorder With Infant Neuromotor Development

et al. 2018

Self Cite

View full text Add to dashboard Cite

Schizophrenia and bipolar disorder (BD) are heritable disorders with similarities in clinical symptoms and typical onset after puberty. 1 While research shows that impaired motor coordination can have an association with schizophrenia, 2 there are limited data on childhood development preceding BD. Murray et al 1 proposed a developmental model for similarities and dissimilarities between schizophrenia and BD, but it remains unknown if dissimilarities exist in early infancy and if they covary with genetic liability for these disorders. Using polygenic risk scores (PRSs), we explored whether genetic risk for schizophrenia and genetic risk for BD are associated with neuromotor development in infancy.

show abstract

Polygenic scores for schizophrenia and educational attainment are associated with behavioural problems in early childhood in the general population

Abstract: Polygenic scores for adult psychiatric disorders and educational attainment are associated with variation in emotional and behavioural problems already at a very early age.

Cited by 75 publications

References 44 publications

Genetic risk for bipolar disorder and psychopathology from childhood to early adulthood

Genetic risk for bipolar disorder and psychopathology from childhood to early adulthood

Editorial Perspective: From schizophrenia polygenic risk score to vulnerability (endo‐)phenotypes: translational pathways in child and adolescent mental health

Association of Genetic Risk for Schizophrenia and Bipolar Disorder With Infant Neuromotor Development

Contact Info

Product

Resources

About