Polygenic Risk Score Improves Prediction of Primary Open Angle Glaucoma Onset in the Ocular Hypertension Treatment Study
Rishabh K. Singh,
Yan Zhao,
Tobias Elze
et al.
Abstract:Objective or Purpose: Primary open-angle glaucoma (POAG) is a highly heritable disease with 127 identified risk loci. Polygenic risks score (PRS) offers a measure of aggregate genetic burden. In this study, we assess whether PRS improves risk stratification in patients with ocular hypertension. Design: A post-hoc analysis of the Ocular Hypertension Treatment Study (OHTS) data. Setting, Participants, and/or Controls: 1636 participants were followed from 1994 to 2020 across 22 sites. The PRS was computed for 100… Show more
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