Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks
Jae-Seung Yun,
Sang-Hyuk Jung,
Su-Nam Lee
et al.
Abstract:Background
Glaucoma is a leading cause of worldwide irreversible blindness. Considerable uncertainty remains regarding the association between a variety of phenotypes and the genetic risk of glaucoma, as well as the impact they exert on the glaucoma development.
Methods
We investigated the associations of genetic liability for primary open angle glaucoma (POAG) with a wide range of potential risk factors and to assess its impact on the risk of inci… Show more
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