Polygenic prediction of human longevity on the supposition of pervasive pleiotropy
M.Reza Jabalameli,
Jhih-Rong Lin,
Quanwei Zhang
et al.
Abstract:The highly polygenic nature of human longevity renders cross-trait pleiotropy an indispensable feature of its genetic architecture. Leveraging the genetic correlation between the aging-related traits (ARTs), we sought to model the additive variance in lifespan as a function of cumulative liability from pleiotropic segregating variants. We tracked allele frequency changes as a function of viability across different age bins and prioritized 34 variants with an immediate implication on lipid metabolism, body mass… Show more
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