Polygalacturonic acid: Another anti-ulcer polysaccharide from the medicinal plant Maytenus ilicifolia

Cipriani, Thales R.; Mellinger, Caroline G.; Souza, Lauro Mera de; Baggio, Cristiane Hatsuko; Freitas, Cristina Setim; Marques, Maria Consuelo Andrade; Gorin, Philip A.J.; Sassaki, Guilherme L.; Iacomini, Marcello

doi:10.1016/j.carbpol.2009.03.026

Cited by 34 publications

(19 citation statements)

References 11 publications

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“…The mechanism suggested for the gastroprotective activity of polysaccharides was their ability to produce a protective layer on the gastric epithelium, and also their capacity to decrease acid and pepsin secretion and increase mucus synthesis. Thus, the results show that these polysaccharides may contribute to the antiulcer property of M. ilicifolia [31].…”

Section: Maytenus Genusmentioning

confidence: 84%

Antiulcer Agents from Higher Plants

Klein‐Júnior

Santin

Andrade

2012

Plant Bioactives and Drug Discovery

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The gastrointestinal tract has its own conformation, with a large surface area that permits high absorption, and glands that produce digestive juices, thereby enabling digestion and absorption of nutrients, in order to maintain the functioning of the organism. One of the segments of the gastrointestinal tract is the stomach. This organ is formed by several layers of smooth muscle and is lined by a mucous membrane. It is anatomically divided into four regions: cardia, fundus, body, and antrum [1,2].The stomach surface contains mucus-secreting cells, which cover the entire surface; peptic cells, which secrete large amounts of pepsinogen; parietal cells, which secrete hydrochloric acid and intrinsic factor; G cells, which secrete gastrin; and chromaffin cells, which secrete histamine [3,4].The stomach has a series of protective barriers, for its primordial function, digestion of proteins, and protection against self-digestion and injuries. The mucosal layer plays a key role, with four levels of protection. The first level is the factors secreted into the lumen (surface phospholipids, bicarbonate, mucus, and prostaglandins); the second level of protection is the epithelium itself; the third level is related to the joint action of the afferent sensory nerve and the microcirculation mucosa and submucosa; and the fourth level of defense is the mucosal immune system, including mast cells and macrophages [5,6]. Thus, disorders involving the secretory and protector functions may be related to the pathogenesis of peptic ulcer [4].

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Section: Maytenus Genusmentioning

confidence: 84%

Antiulcer Agents from Higher Plants

Klein‐Júnior

Santin

Andrade

2012

Plant Bioactives and Drug Discovery

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“…Previously, several types of plant polysaccharides have shown anti-ulcer activities (Cipriani et al, 2008(Cipriani et al, ,2009Tanaka et al, 2010;Ye et al, 2003) and some of these also show immunomodulating (Matsumoto et al, 2002;Nergaard et al, 2005). As H. pylori infection often is the main reason for gastric ulcer formation (Pahwa et al, 2010) the use of plants containing immunomodulating polysaccharides might be beneficial.…”

Section: Introductionmentioning

confidence: 94%

Anti-ulcer polysaccharides from Cola cordifolia bark and leaves

Austarheim

Haïdara

Sanogo

et al. 2012

Journal of Ethnopharmacology

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“…It is used in folk medicine for the treatment of dyspepsia as well as gastric ulcers and potentially on cancer treatment [2]- [4] Cipriani et al demonstrated, after several purification steps, that the tea (infusion) of M. ilicifolia leaves releases a polysaccharide (arabinogalactan). The pre-treatment with arabinogalactan practically abolished the ethanol-induced gastric damage, suggesting a potential ability to bind to the surface mucosa and function as a protective coating, antisecretory activity, and mucosal protection by increased mucus synthesis, and radical scavenging [5].…”

Section: Introductionmentioning

confidence: 95%

Anti-ulcerogenic Action Mechanism of <i>Maytenus ilicifolia</i> Detected by mRNA RT-PCR and Free Radical Scavenging Activity Evaluated by ESR

Pazzini¹

2017

AJHR

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Abstract:Maytenus ilicifolia, known as "espinheira-santa", is used in the popular medicine for peptic ulcer treatment.This work evaluates the preventive and curative actions of M. ilicifolia in animals, the healing activity by EGF expression detected by RT-PCR as well as the anti-oxidative activity by Electron Spin Resonance spectroscopy (ESR). Oral administration of M. ilicifolia (300 and 500 mg/kg, p.o.) one hour before the ulcerogenic agent application prevented the ulcer formation 42 ± 0.98% and 72 ± 1.2% (p <0.05 and p <0.001, respectively), in comparison with the negative control tween 80, preserving the cytoprotection characteristics of the gastric mucosa and assuring the integrity of gastric glands and gastric fossets. The animals treated with tween, had the epithelium and the mucosa layer damaged and accentuated vascularization. The healing activity of M. ilicifolia (500mg/kg, p.o.) was 71 ± 1.4% (p <0.001) in chronic ulcer experiments induced by acetic acid. EGF expression detected by RT-PCR confirmed the healing activity. Histological analysis showed the recovery of the mucosal layer and the epithelium surface harmed by the acetic acid. Studies in vitro by Electron Spin Resonance spectroscopy assessed the anti-oxidative action of M ilicifolia. Experiments with DPPH (2.2-Diphenyl -1-picrylhydrazyl) demonstrated that the polar fraction of M. ilicifolia presents an IC 50 of 0.68±0.09 mg/ml. The value of 9±2 mg/ml was found for IC 50 in experiments with the radical OH, produced by the Fenton Reaction and detected through spin adduct DMPO-OH. Mass spectrometry analysis of crude extracts and fractions from M. ilicifolia was carried out and compounds of pentacyclic triterpenes class were identified.

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Polygalacturonic acid: Another anti-ulcer polysaccharide from the medicinal plant Maytenus ilicifolia

Cited by 34 publications

References 11 publications

Antiulcer Agents from Higher Plants

Antiulcer Agents from Higher Plants

Anti-ulcer polysaccharides from Cola cordifolia bark and leaves

Anti-ulcerogenic Action Mechanism of <i>Maytenus ilicifolia</i> Detected by mRNA RT-PCR and Free Radical Scavenging Activity Evaluated by ESR

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Polygalacturonic acid: Another anti-ulcer polysaccharide from the medicinal plant Maytenus ilicifolia

Cited by 34 publications

References 11 publications

Antiulcer Agents from Higher Plants

Antiulcer Agents from Higher Plants

Anti-ulcer polysaccharides from Cola cordifolia bark and leaves

Anti-ulcerogenic Action Mechanism of &lt;i&gt;Maytenus ilicifolia&lt;/i&gt; Detected by mRNA RT-PCR and Free Radical Scavenging Activity Evaluated by ESR

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Anti-ulcerogenic Action Mechanism of <i>Maytenus ilicifolia</i> Detected by mRNA RT-PCR and Free Radical Scavenging Activity Evaluated by ESR