Polyfluoroalkyl Substances Binding Properties and Impact on Human Health: Physiochemical Properties, Impact of Multiple PFAS Compounds, Variation among Species, and Fluoride Interaction

Abstract

PFAS are chemical compounds that are found in consumer goods and are known contaminates found in both the environment and within the body. Research has begun to help better understand these compounds and how they impact human health and the environment. PFAS have many different characteristics that make it difficult to understand their full impact and it is suggested that their unique properties have a significant impact on their ability to act in the body. PFAS are even more complex because they can bio transform and interact with each other exhibiting competitive behavior. Studies also suggest that there are differences among species when exposed to PFAS and the physiological pathways impacted. Another interaction that can have human and environmental implications is that there is evidence of interactions between fluoride in the water with the PFAS contaminates. The purpose of this review paper is to provide public health professionals the risk assessment tools to understand the properties of these compounds, not addressed to date and to better understand how PFAS react in the body, interact with one another, and interact with other inorganic substances.