Polyfluoro 1,3-diketones as systemic insecticides

Abstract

A series of aryl polyfluoro 1,3-diketones were examined for systemic ectoparasiticidal activity in cattle. The compounds demonstrated efficacy against several economically important species of insects and acarina. At dosages of 5 mg/kg X1 or 0.35 mg/kg per day intraruminally, activity was observed against blowfly larvae (Phormia regina), adult stable fly (Stomoxys calcitrans), and lone star tick (Amblyomma americanum). In vivo activity was not directly related to in vitro activity, showing a stronger dependence on perfluoroalkyl-chain length and aryl-group substitution.

Chemistry of fluoro-substituted β-diketones and their derivatives

“…Insecticide activity was revealed for polyfluorinated aryl-1,3-diketones with different length of the perfluoroacyl chain and with substituents in the aromatic ring. 47 Bis-and tris(trifluoromethyl)-substituted pyrimido[1,2-b]indazoles possess antitumour activity. 123 4-Phenyl-and 3-alkyl(aryl)-5-hydroxy-1-tosyl-5-trifluoromethyl-4,5-dihydro-1H-pyrazoles manifested antibacterial activity.…”

Synthesis, Characterization and Antimicrobial Screening of 1,3-Dione with their Metal Complexes

“…The functionalized 1,3-diones are potential antibacterial [1], antiviral [2], insectitial [3], antioxidant [4], antisunscreen activity [5], antitumor [6], HIV-1 Integrase (IN) inhibitors [7]. 1,3-Dione are key intermediate for the synthesis various heterocyclic compounds [8][9][10].…”

Synthesis, Spectral Characterization and Biological Screening of Potentially Active 1, 3-Diones and its Transition Metal Complexes

“…1, 3-Diones have broad spectrum of medicinal values which shown to have pharmacological activity like antibacterial 1 , antiviral 2 , insecticidal 3 , antioxidant 4 and potential prophylactic antitumor activity 5,6 . It has also been used in the anti-sunscreen agent 7 .…”