Abstract:For an effective medical application of therapeutic siRNA, a safe and an efficient delivery system are required. Herein, magnetic nanoparticles (MNPs) have been successfully used as siRNA delivery vehicles. Firstly, MNPs were coated with gold (Au) nanoparticles and then capped with PEI. To improve the biocompatibility of nanoparticles, hyaluronic acid (HA) was coated onto the surface of PEI-Au/Fe nanoparticles. The prepared HA-PEI-Au/Fe3O4 nanoparticles were characterized and found to be uniform and well segre… Show more
“…Raju et al prepared HAase-responsive nanoparticles by coating the surface of PEI-Au/Fe nanoparticles with HA. 40 The nanoparticles as intracellular transport carriers of ADAM10 siRNA can effectively inhibit the growth of prostate cancer cells.…”
HA/(MI)7-β-CD NCs exhibits HA receptor-mediated targeting and disassembly properties under HAase stimulation, which was utilized to trap, targeted deliver and controlled release of anti-liver cancer compound CSL.
“…Raju et al prepared HAase-responsive nanoparticles by coating the surface of PEI-Au/Fe nanoparticles with HA. 40 The nanoparticles as intracellular transport carriers of ADAM10 siRNA can effectively inhibit the growth of prostate cancer cells.…”
HA/(MI)7-β-CD NCs exhibits HA receptor-mediated targeting and disassembly properties under HAase stimulation, which was utilized to trap, targeted deliver and controlled release of anti-liver cancer compound CSL.
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