2014
DOI: 10.1099/jmm.0.069609-0
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Polyethyleneimine and polyethyleneimine-based nanoparticles: novel bacterial and yeast biofilm inhibitors

Abstract: Biofilms are commonly involved in medical device-related infections. The purpose of this study was to determine the antimicrobial and anti-biofilm activity of polyethyleneimine (PEI) and PEIbased nanoparticles (nanoPEI) against Staphylococcus aureus, Staphylococcus epidermidis, Acinetobacter baumannii and Candida albicans (clinical and ATCC strains), and to evaluate their effect upon biofilm formation on polyurethane (PUR)-like catheters. MICs and minimal lethal concentrations of PEI and nanoPEI were determine… Show more

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Cited by 81 publications
(61 citation statements)
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“…Immortelle ( Helichrysum italicum (Roth) G. Don., Asteraceae) EO reduced the resistance to chloramphenicol of A. baumannii ATCC 19606 and the AB1 strain isolated from central venous catheters of critical care patients [37,38]. In the case of both strains, immortelle EO reduced by eight-fold the MIC value of chloramphenicol in combination, whereas phenylalanine-arginine β-naphthylamide (PaβN), a potent efflux pumps inhibitor, caused only a two-fold reduction.…”
Section: Essential Oils and Volatile Compounds Modulating Antibiotmentioning
confidence: 99%
“…Immortelle ( Helichrysum italicum (Roth) G. Don., Asteraceae) EO reduced the resistance to chloramphenicol of A. baumannii ATCC 19606 and the AB1 strain isolated from central venous catheters of critical care patients [37,38]. In the case of both strains, immortelle EO reduced by eight-fold the MIC value of chloramphenicol in combination, whereas phenylalanine-arginine β-naphthylamide (PaβN), a potent efflux pumps inhibitor, caused only a two-fold reduction.…”
Section: Essential Oils and Volatile Compounds Modulating Antibiotmentioning
confidence: 99%
“…The effectiveness of Ag NPs is also augmented with compounds such as polyethyleneimines, chitosan and glucosamine that serve as ligands and reinforce their uptake into bacterial cells. 128 Chitosan has inherent antimicrobial properties due its polycationic character. Low-molecular weight chitosan-coated Ag NPs have been reported to surpass polyvinylpyrrolidone-coated Ag NPs and Ag NPs without surface stabilizer (uncoated Ag NPs) in efficacy against MRSA with enhanced biocompatibility and reduced body absorption characteristics.…”
Section: Polymeric Nanocomposites and Nanomaterials Conjugated With Amentioning
confidence: 99%
“…Indeed, the antimicrobial assay revealed that most of compounds tested had no or negligible activity against S. aureus and B. subtilis with the exception of some acid derivatives (3a, 3b, and 3g). This observation could be explained by the difference in the cell wall structure of Gram-positive and Gram-negative bacteria or it may be due to the charges and the kinetics of the chemical compounds, which can damaged the bacterial cell wall via electrostatic interactions, as previously reported by Azevedo et al [39].…”
Section: Biologymentioning
confidence: 61%