Polyethylene glycol (PEG) in mRNA-based COVID-19 vaccines: Impact, immunogenicity, and its potential role in post-vaccination induced hypersensitivity.
Abstract:Polyethylene glycol (PEG) is the most commonly used hydrophilic polymer in cosmetics and polymer-based drug delivery systems. PEGylation of nanocarriers has gained a lot of interest nowadays as it improves the circulation half-life and formulation stability. Recently, messenger ribonucleic acid (mRNA)-based coronavirus (COVID-19) vaccines depend on the delivery of mRNA to the cytosol and then being transcribed into the antigenic proteins that prime the immune system to produce specific antibodies (Abs) that ca… Show more
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