Polyethylene glycol (PEG) derived carbon dots: Preparation and applications

Peng, Zhili; Ji, Chunyu; Zhou, Yiqun; Zhao, Tianshu; Leblanc, Roger M.

doi:10.1016/j.apmt.2020.100677

Cited by 78 publications

(59 citation statements)

References 124 publications

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“…45 The process leading to the formation of C-dots relies on the pyrolysis-clustering-carbonization which is assisted by the direct heating in the air in our case. 45,53,54 This hypothesis is further supported by the fact that UV-vis absorption spectra present a strong absorbance at low wavelength related to Cdots, for all samples annealed at 200 °C. 55 Moreover, the yellow colour of the solution after annealing is proof of the presence of these C-dots.…”

Section: Global Overviewsupporting

confidence: 54%

Insights into the growth of nanoparticles in liquid polyol by thermal annealing

et al. 2021

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Section: Global Overviewsupporting

confidence: 54%

Insights into the growth of nanoparticles in liquid polyol by thermal annealing

et al. 2021

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“…Importantly, the functional groups at the surface can be modified during their synthesis to fine-tune the C-dots’ photoluminescent properties (Zhou, Mintz, et al, 2019 ; Dan et al, 2020 ), or to adapt C-dots to function as pharmaceutical nanocarriers (Zheng et al, 2014 ; Zhou, Liyanage, et al, 2019 ). For example, the surface of C-dots can be passivated with polyethylene glycol (Sun et al, 2006 ; Peng et al, 2020 ), and then conjugated covalently or noncovalently with diverse therapeutic agents drugs (Thakur et al, 2014 ; Iannazzo et al, 2017 ; Hettiarachchi et al, 2019 ; Liyanage et al, 2020 ). These modifications, however, can have unexpected consequences for both the C-dot vehicle and the drug cargo, including affecting the solubility, therapeutic efficacy, and systemic clearance of the drug (Misra et al, 2015 ; Li, Amat, et al, 2016 ; Li et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

In vivo characterization of carbon dots–bone interactions: toward the development of bone-specific nanocarriers for drug delivery

et al. 2021

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Current treatments for osteoporosis and other bone degenerative diseases predominately rely on preventing further bone erosion rather than restoring bone mass, as the latter treatments can unintentionally trigger cancer development by undiscriminatingly promoting cell proliferation. One approach to circumvent this problem is through the development of novel chemical carriers to deliver drug agents specifically to bones. We have recently shown that carbon nanodots (C-dots) synthesized from carbon nanopowder can bind with high affinity and specificity to developing bones in the larval zebrafish. Larval bones, however, are physiologically different from adult bones in their growth, repair, and regeneration properties. Here we report that C-dots can bind to adult zebrafish bones and that this binding is highly specific to areas of appositional growth. C-dots deposition occurred within 30 minutes after delivery and was highly selective, with bones undergoing regeneration and repair showing higher levels of C-dots deposition than bones undergoing normal homeostatic turnover. Importantly, C-dots deposition did not interfere with bone regeneration or the animal’s health. Together, our results establish C-dots as a potential novel vehicle for the targeted delivery of drugs to treat adult bone disease.

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“…In addition to the functional groups, sometimes the surfaces of CDs are decorated with surfactants (e.g., PEG, TTDDA) that improve and stabilize PL emission form CDs. [ 63 ] For more details about the surface chemistry of CDs and functional groups on their surface, the comprehensive review published by Yan et al. [ 62 ] is recommended.…”

Section: Propertiesmentioning

confidence: 99%

Carbon Dots and Stability of Their Optical Properties

Javed

O’Carroll

2021

Part & Part Syst Charact

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exploited for fabrication of light-emitting devices, [5] and their remarkable electronic properties have been used in the fields of photovoltaics [6] and electronics. [5d,7] Low toxicity and the excellent biocompatibility of CDs encourage researchers to study the role of CDs in the biomedical field, and many bioimaging [8] and drug delivery [9] applications of CDs have been reported. The dependence of the optical properties of CDs on the presence of metal ions in dispersion has been exploited for cation detection applications. [10] Besides this, CDs have been demonstrated to be useful for energy storage, [11] photocatalysis, [12] electrochemical sensing, [13] electrochemiluminescence sensing, [13,14] sensing and killing microorganisms [15] including viruses, [16] and numerous other applications. Although there have been several lab-scale demonstrations of a variety of different applications of CDs, there are hardly any commercially available device based on CDs. [3] To commercialize CD-based devices/applications, stable and predictable PL emission is one of the most important requirements. In a few early studies of the properties of CDs, it was reported that the PL emission of CDs is photostable, that is, CDs are photostable. [17] Additionally, the PL quantum yield (QY) of CDs reported in early studies was very low, typically less than 10%, and emission was mostly understood to arise from the presence of surface functional groups. In recent years, due to improvements in synthesis methods and use of different raw materials, remarkable increases in the PL QY of CDs have been reported. [18] Often the bright PL emission from these CDs is comparable to that of molecular fluorophores. Molecule-like bright emission from CDs is often attributed to the presence of molecular fluorophores on the surface of CDs [19] or sometimes freely floating in dispersion due to poor purification. [20] This striking change in the optical properties gave rise to observations of other molecular features in CDs, like blinking and photobleaching.Despite hundreds of published studies exploring the synthesis, properties and application of CDs, there are relatively few reports that consider the photostability of CDs. Most reports that showed CDs to be photostable were carried out in the early years of the development of CDs, and, consequently, CDs are still considered to be photostable. However, there are also some more recent reports showing significant photobleaching of CDs. Here, we review published work on the photostability of CDs. It is noted that while there is a wide variation in the reported photostability of CDs, there is also a lack of homogeneous systematic studies. In most studies of photobleaching the geometry of the experiment (i.e., the Carbon dots (CDs) are a new class of materials which have been extensively studied due to their unique optical properties, low toxicity, and abundance of raw materials to synthesize them. In this minireview, it is highlighted that the stability of the optical properties of CDs is an important...

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Polyethylene glycol (PEG) derived carbon dots: Preparation and applications

Cited by 78 publications

References 124 publications

Insights into the growth of nanoparticles in liquid polyol by thermal annealing

Insights into the growth of nanoparticles in liquid polyol by thermal annealing

In vivo characterization of carbon dots–bone interactions: toward the development of bone-specific nanocarriers for drug delivery

Carbon Dots and Stability of Their Optical Properties

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