Polyethylene glycol-modified mesoporous polydopamine nanoparticles co-loaded with dimethylcurcumin and indocyanine green for combination therapy of castration-resistant prostate cancer

Hong, Jun Hyuk; Tang, Ya-Ting; Zhou, Mengting; Deng, Jing; Hu, Hang; Xu, Defeng

doi:10.1016/j.jddst.2022.103158

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…[12][13][14] DMC is reported to selectively promote AR degradation, resulting in the inhibition of AR transcriptional activity and prostate cancer cell growth. [15][16][17] In addition, DMC is proven to be effective in the control of various AR-associated diseases. 18,19 Compared with anti-androgen therapies, anti-AR therapy with DMC might better suppress castration-resistant prostate cancer progression and metastasis.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of curcumin derivatives for suppression of castration-resistant prostate cancer

Gong,

Yuan,

et al. 2024

Journal of Chemical Research

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In this work, 20 curcumin derivatives containing halogen atoms or nitrogen atoms were synthesized for suppression of castration-resistant prostate cancer. These curcumin derivatives were prepared by aldol condensation between the substituted benzaldehydes and acetylacetone or ethyl 3-acetyl-4-oxopentanoate. All synthesized compounds were characterized by 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, high resolution mass, ultraviolet–visible spectroscopy, fluorescence spectroscopy, and high-performance liquid chromatography. The in vitro cytotoxicity of the prepared compounds against 22Rv1 cells was evaluated by the standard MTT assay. The compounds with good inhibitory activity against 22Rv1 cells were further tested for androgen receptor suppression effect. The results show that all compounds were successfully prepared and the purities are all over 90%. Among all synthesized compounds, compound p and s exhibit better inhibitory activity against 22Rv1 cells as compared to dimethylcurcumin, compound q and r display similar inhibitory activity against 22Rv1 cells as compared to dimethylcurcumin. Compounds p-s also demonstrate enhanced androgen receptor suppression effect against 22Rv1 cells as compared to dimethylcurcumin. This work indicates that compounds p-s show promising inhibitory activity against castration-resistant prostate cancer cells by suppression of androgen receptor.

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Section: Introductionmentioning

confidence: 99%

Synthesis of curcumin derivatives for suppression of castration-resistant prostate cancer

Gong,

Yuan,

et al. 2024

Journal of Chemical Research

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“…In addition, ICG has been proposed for breast cancer imaging (Toh et al, 2015). ICG could generate fluorescence, hyperthermia and singlet oxygen upon 808 nm laser irradiation, which allows ICG to be used for molecular imaging and phototherapy in cancer diagnosis and therapeutics (Chen et al, 2016;Hong et al, 2022;Pollmann et al, 2023). Besides, ICG has been widely investigated to combine with other therapeutics such as immunotherapy, chemotherapy and radiotherapy to better suppress cancer (Lian et al, 2023;Lu et al, 2023;Sun et al, 2022;Tu et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Biotin‐new indocyanine green conjugate: Synthesis, in vitro photocytotoxicity and in vivo biodistribution

Liu,

Ding,

et al. 2024

Chem Biol Drug Des

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New indocyanine green (ICG) (IR820) is one of the ICG derivatives and attracts increasing attention for cancer management. However, the unsatisfactory tumor targeting ability of IR820 significantly limits its applications for cancer theranostics. Biotin receptor is overexpressed on the membrane of various tumor cells and biotin modified nanocarriers have been reported to enhance the tumor targeting ability on several tumor types. In this work, biotin‐new ICG conjugate (Biotin‐SS‐IR820) was prepared for tumor‐targeted IR820 delivery. Biotin and IR820 were coupled through cystamine. The synthesized Biotin‐SS‐IR820 was characterized by 1H NMR, FT‐IR and HRMS. The in vitro singlet oxygen generation study shows that Biotin‐SS‐IR820 exhibits similar singlet oxygen generation as compared to IR820 upon 660 nm laser irradiation (0.8 W/cm2). The cellular uptake study shows that Biotin‐SS‐IR820 shows enhanced cellular uptake amount as compared to IR820 on 4T1 cells. As a result, Biotin‐SS‐IR820 displays enhanced in vitro photodynamic therapeutic effect against 4T1 cells as compared to IR820. In in vivo biodistribution study, Biotin‐SS‐IR820 shows enhanced tumor accumulation as compared to IR820. Biotin‐SS‐IR820 developed in this work shows promising prospects for targeted delivery of IR820 to biotin receptor overexpressed tumors.

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“…Nanomedicine is typically applied for cancer therapeutics through one or a combination of treatment modalities, namely photothermal therapy, photodynamic therapy, chemotherapy, or immunotherapy 9 - 16 . Nanoparticles have been developed that utilizes near-infrared (NIR) responsive photo absorbers to produce local heat, i.e., photothermal transduction process to kill the cancer cells/tumor tissue upon NIR irradiation 17 .…”

Section: Introductionmentioning

confidence: 99%

A lipo-polymeric hybrid nanosystem with metal enhanced fluorescence for targeted imaging of metastatic breast cancer

Appidi,

Sivasankaran,

Chinchulkar

et al. 2024

Nanotheranostics

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Cancer metastasis plays a major role in failure of therapeutic avenues against cancer. Owing to metastasis, nearly 70-80% of stage IV breast cancer patients lose their lives. Nanodrug delivery systems are playing a critical role in the therapy of metastatic cancer in the recent times. This paper reports the enhanced permeation and retention (EPR) based targeting of metastatic breast cancer using a novel nano lipo-polymeric system (PIR-Au NPs). The PIR-Au NPs demonstrated an increase in fluorescence by virtue of surface coating with gold, owing to the metal enhanced fluorescence phenomenon as reported in our earlier reports. Enhanced fluorescence of PIR-Au NPs was observed in murine mammary carcinoma cell line (4T1), as compared to free IR780 or IR780 loaded nanosystems (P-IR NPs), when incubated for same time at same concentrations, indicating its potential application for imaging and an enhanced bioavailability of IR780. Significant cell death was noted with photothermal mediated cytotoxicity in-vitro against breast cancer cells (MCF-7 and 4T1). An enhanced fluorescence was observed in the zebra fish embryos incubated with PIR-Au NPs. The enhanced permeation and retention (EPR) effect was seen with PIR-Au NPs in-vivo . A strong fluorescent signal was recorded in mice injected with PIR-Au NPs. The tumor tissue collected after 72 h, clearly showed a greater fluorescence as compared to other groups, indicating the plasmon enhanced fluorescence. We also demonstrated the EPR-based targeting of the PIR-Au NPs in-vivo by means of photothermal heat . This lipo-polymeric hybrid nanosystem could therefore be successfully applied for image-guided, passive-targeting to achieve maximum therapeutic benefits.

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Polyethylene glycol-modified mesoporous polydopamine nanoparticles co-loaded with dimethylcurcumin and indocyanine green for combination therapy of castration-resistant prostate cancer

Cited by 6 publications

References 38 publications

Synthesis of curcumin derivatives for suppression of castration-resistant prostate cancer

Synthesis of curcumin derivatives for suppression of castration-resistant prostate cancer

Biotin‐new indocyanine green conjugate: Synthesis, in vitro photocytotoxicity and in vivo biodistribution

A lipo-polymeric hybrid nanosystem with metal enhanced fluorescence for targeted imaging of metastatic breast cancer

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