Polyethylene Glycol for Constipation in Children Younger Than Eighteen Months Old

Michail, Sonia; Gendy, Elizabeth; Preud'Homme, Daniel; Mezoff, Adam

doi:10.1097/00005176-200408000-00014

Cited by 68 publications

(42 citation statements)

References 9 publications

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“…Both milk of magnesia and polyethylene glycol 3350 without electrolytes were efficient and safe in our infants and toddlers. The safety and efficiency of polyethylene glycol in children <18 months of age was also reported recently by Michail et al 14 It has been reported that cow's milk protein intolerance is a cause of constipation in young children. 15 Intolerance to cow's milk protein occurs in 0.3% to 7.5% of otherwise healthy infants.…”

Section: Discussionsupporting

confidence: 71%

Prevalence, symptoms and outcome of constipation in infants and toddlers

Loening‐Baucke

2005

The Journal of Pediatrics

181

127

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Section: Discussionsupporting

confidence: 71%

Prevalence, symptoms and outcome of constipation in infants and toddlers

Loening‐Baucke

2005

The Journal of Pediatrics

181

127

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“…Constipation secondary to morphine was observed in 40.9% of patients in the first week, in 38.8% in the second week and in 16.6% in the third week. In spite of the small number of patients, these results may be considered similar to the international literature 17,18 and are attributed, in addition to the drugs, to the fact that the study was prospective and that specific attention was given to constipation. It is worth reminding that, according to the literature, constipation secondary to morphine affects 70% to 80% of terminal patients and is difficult to contro l7, 13,14,19 .…”

Section: Discussionsupporting

confidence: 82%

Avaliação do hábito intestinal em pacientes com câncer que utilizam morfina para o controle da dor

Marmo¹,

Caran²,

Puty³

et al. 2012

Rev. dor

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“…Mais recentemente, o polietilenoglicol (PEG) vem sendo citado como opção terapêutica [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] na CICF em pediatria.…”

Section: Introductionunclassified

Comparison of the effectiveness of polyethylene glycol 4000 without electrolytes and magnesium hydroxide in the treatment of chronic functional constipation in children

Gomes¹,

Duarte²,

Melo³

2010

J Pediatr (Rio J)

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Objective: To compare the effectiveness of two drugs, polyethylene glycol 4000 without electrolytes and magnesium hydroxide, in the treatment of chronic functional constipation in children.Methods: Thirty-eight children were randomly assigned to either of two groups, polyethylene glycol 4000 without electrolytes or magnesium hydroxide. The children were followed through periodic appointments until they reached 6 months of treatment. In each medical appointment the following aspects were evaluated: stool consistency, frequency of bowel movements, fecal incontinence, abdominal pain, straining and acceptance of the drugs.Results: Seventeen children made use of polyethylene glycol and twenty-one received magnesium hydroxide. All variables analyzed improved for both groups, with no statistically significant differences. All children accepted polyethylene glycol, while 42.9% refused magnesium hydroxide. Conclusion:The two laxatives showed no difference in effectiveness for the treatment of constipation. However, due to its better acceptance, because it is odorless and tasteless, polyethylene glycol proved to be a better option for treating chronic functional constipation.J Pediatr (Rio J). 2011;87(1):24-28: Treatment, children, constipation. ResumoObjetivo: Comparar a efetividade de dois medicamentos: hidróxido de magnésio e polietilenoglicol 4000 sem eletrólitos no tratamento da constipação intestinal crônica funcional em crianças. Métodos:Trinta e oito crianças foram divididas, por processo randô-mico, em dois grupos para uso de polietilenoglicol 4000 sem eletrólitos ou de hidróxido de magnésio. As crianças foram acompanhadas em consultas periódicas até completarem 6 meses de tratamento. Em todas as consultas, foram investigados: consistência das fezes, frequência evacuatória, presença de escape fecal, dor abdominal, esforço evacuatório e aceitação desses fármacos.Resultados: Dezessete crianças fizeram uso de polietilenoglicol, e 21 utilizaram o hidróxido de magnésio. Houve melhora clínica de todas as variáveis nos dois grupos, sem diferenças com significância estatís-tica. Todas as crianças aceitaram o polietilenoglicol, enquanto 42,9% recusaram o hidróxido de magnésio.Conclusão: Não houve diferença de efetividade no tratamento da constipação intestinal entre esses dois laxantes. Entretanto, a melhor aceitação do polietilenoglicol, por ser inodoro e insípido, torna-o melhor opção no tratamento da constipação intestinal crônica funcional.

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Polyethylene Glycol for Constipation in Children Younger Than Eighteen Months Old

Abstract: Oral powdered polyethylene glycol at a maintenance dose of 0.78 g/kg/day is safe and effective for patients younger than 18 months. Dose and safety profiles are similar for those reported in older children.

Cited by 68 publications

References 9 publications

Prevalence, symptoms and outcome of constipation in infants and toddlers

Prevalence, symptoms and outcome of constipation in infants and toddlers

Avaliação do hábito intestinal em pacientes com câncer que utilizam morfina para o controle da dor

Comparison of the effectiveness of polyethylene glycol 4000 without electrolytes and magnesium hydroxide in the treatment of chronic functional constipation in children

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