Polyethylene glycol-derived polyelectrolyte–protein nanoclusters for protein drug delivery

Abstract

Polyethylene glycol-derived polyelectrolyte–protein nanoclusters were synthesized based on electrostatic complexation for protein drug delivery.

Nanoparticles targeting the adenosine pathway for cancer immunotherapy

“…At the same time, the nanodelivery system can also improve protein solubility and bioavailability, improve treatment effectiveness and reduce side effects. 116 Zhao and colleagues studied an injectable hydrogel composed of ADA, doxorubicin (DOX), tricarboxylic acid (BTC), and sodium alginate. 117 In the tumor microenvironment, the synergistic action of DOX and BTC promoted ATP induction, while ADA catalyzed the conversion of adenosine to inosine, resulting in a significant antitumor effect.…”

Recent advances of the nanocomposite hydrogel as a local drug delivery for diabetic ulcers

“…Compared with small-molecule drugs, protein drugs have become a hot field of new drug development because of their high activity, high specificity, low physiological toxicity and good biocompatibility. However, the unique molecular structure and biochemical characteristics rapidly inactivate protein drugs in complex biological environments, which limits their application to biomedicine ( Yu Y. et al, 2021 ). It has been shown that nanocomposite hydrogels can encapsulate protein drugs in their internal network structure, thus protecting them from the external environment ( Li M. et al, 2017 ; Wang Z. et al, 2019 ; Zhou et al, 2022 ).…”