“…Natural products can have many advantages over chemotherapy, such as low toxicity, low side effects, multiple targets, and reversal of resistance to cancer drugs. Magnolol (MAG, 5,5′-diallyl-2,2′-dihydroxybiphenyl), a lignan isolated mainly from Magnolia officinalis , Rehder & E.H. Wilson (“Hou Po” in Chinese) [ 8 ], exhibits a huge range of biological activities such as anti-inflammatory [ 9 ], neuroprotective [ 10 ], antibacterial [ 11 ], antioxidant [ 12 ], and antitumor [ 13 ] effects. In addition, many recent studies have shown that MAG can inhibit the proliferation, migration, metastasis, and angiogenesis of various cancer cell lines [ 14 , 15 , 16 , 17 ], suggesting that MAG has potential as a lead compound for the discovery of anticancer agents.…”