Polyethylene glycol and contrast-enhanced MRI of Crohn's disease in children: preliminary experience

Magnano, Gianmichele; Granata, Claudio; Barabino, A.; Magnaguagno, Francesca; Rossi, Umberto; Calevo, Maria Grazia; Tomà, Paolo

doi:10.1007/s00247-003-0903-z

Cited by 65 publications

(44 citation statements)

References 11 publications

(17 reference statements)

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“…In the ileoscopy (b) ileal mucosa shows erythema. Erosions and ulcers are also present enteroclysis CT and PEG for enterography CT; methylcellulose is already widely employed both in small-bowel enema and in CT [10][11][12][13][14][15]; PEG is mainly used in MRI [16,17] and more rarely in CT [14,18]. The choice of PEG was based on the fact it is a well-known solution in widespread use for the preparation of endoscopic studies.…”

Section: Discussionmentioning

confidence: 99%

Enteroclysis CT and PEG-CT in patients with previous small-bowel surgical resection for Crohn’s disease: CT findings and correlation with endoscopy

Minordi¹,

Vecchioli²,

Poloni³

et al. 2009

Eur Radiol

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The aim of this study was to evaluate the accuracy of multidetector CT in patients with Crohn's disease (CD) relapse after ileocolic resection compared with endoscopy. Thirty-four patients were studied by endoscopy and multidetector CT, after oral administration of polyethylene glycol solution (n = 21) or after administration of methylcellulose via nasojejunal tube (n = 13). In CT examinations we evaluated the presence of mural thickening, target sign, perienteric stranding, comb sign, fibrofatty proliferation and complications. Endoscopic results were classified in accordance with Rutgeerts score (from 0 to 4). The statistical evaluations were carried out by using Fisher's exact text and chi (2) testing (p < 0.05, statistically significant difference). Sensitivity, specificity and accuracy of the CT were 96.9%, 100% and 97%, respectively. We found a statistically significant correlation between an endoscopic score of 4 and the CT signs of target sign, perienteric stranding, comb sign and fibrofatty proliferation, and between scores 1 and 2 and mucosal hyperdensity without or with mural thickening, respectively (p < 0.05). Moreover, only CT identified the presence of jejunal and proximal ileum disease in two and three patients, respectively, and fistulas in three patients. CT is a reliable method in the diagnosis of CD relapse and shows agreement with the approved endoscopic Rutgeerts score.

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Section: Discussionmentioning

confidence: 99%

Enteroclysis CT and PEG-CT in patients with previous small-bowel surgical resection for Crohn’s disease: CT findings and correlation with endoscopy

Minordi¹,

Vecchioli²,

Poloni³

et al. 2009

Eur Radiol

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“…About 25 min before the examination, patients were administered an oral contrast agent, polyethylene glycol (PEG) (1,000 ml for adults; 10 ml/Kg body weight for children) to distend the small bowel [21,30,38]. Just before the examination, they received an intramuscular vial of butyl scopolamine (Buscopan) to reduce intestinal peristalsis [31,39].…”

Section: Methodsmentioning

confidence: 99%

“…In Crohn's disease, it is able to demonstrate both stenosis and extraluminal complications such as fistulae and abscesses [23]. The technique does not make use of ionising radiation, an important feature if we consider that Crohn's disease predominantly affects young subjects [15,[24][25][26][27][28][29][30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Assessment of inflammatory activity in Crohn’s disease by means of dynamic contrast-enhanced MRI

et al. 2007

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“…On histology, there is a central collection of dense acute inflammation with cellular debris and a thick fibro-inflammatory wall. MRI has a high accuracy in the detection of intraabdominal abscesses showing an overall sensitivity of 93%, and a specificity of 96% [16,17,20]. …”

Section: Crohn's Disease Related Complicationsmentioning

confidence: 99%

MRI of Crohn’s disease: from imaging to pathology

et al. 2011

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Technological advances in the area of magnetic resonance imaging (MRI) raised expectations on the potential role of this imaging modality for evaluation of the gastrointestinal tract, especially on Crohn's disease (CD), based on the high spatial and tissue resolution as well as lack of ionizing radiation. Available evidence indicates that MRI has a high diagnostic accuracy for the detection of disease activity, location of the lesions, and also for determining the severity of the disease, which together are the main aspects for the therapeutic decision-making in patients with CD. MRI provides a high accuracy in detection of strictures, characterization of fistulizing lesions and extraluminal complications such us abscesses which are a key finding for considering medical and surgical options. Knowledge of the pathological substrate of inflammatory lesions in CD as well as extraenteric lesions may improve diagnostic image interpretation, and thus contribute to optimize patient care.

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Polyethylene glycol and contrast-enhanced MRI of Crohn's disease in children: preliminary experience

Cited by 65 publications

References 11 publications

Enteroclysis CT and PEG-CT in patients with previous small-bowel surgical resection for Crohn’s disease: CT findings and correlation with endoscopy

Enteroclysis CT and PEG-CT in patients with previous small-bowel surgical resection for Crohn’s disease: CT findings and correlation with endoscopy

Assessment of inflammatory activity in Crohn’s disease by means of dynamic contrast-enhanced MRI

MRI of Crohn’s disease: from imaging to pathology

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