Polyethylene glycol: A recyclable solvent system for the synthesis of benzimidazole derivatives using CAN as catalyst

Abstract

Ceric ammonium nitrate (CAN) efficiently catalysed the synthesis of benzimidazole derivatives from o-phenylenediamine and aldehydes in PEG. This method provides a novel route for the synthesis of benzimidazoles in good yields with little catalyst loading. The recovery and the successful reutilization of the solvent system are also presented. Moreover, the easy set-up and purification tasks of this sustainable method make it appealing for bulk industry applications.

Green Synthesis of Benzimidazole Derivatives: an Overview on Green Chemistry and Its Applications

“…It is the synthesized benzimidazole by reacting OPD with several aldehydes using a green solvent PEG400 and got good yields [45]. Scheme 14.…”

SBSA as a New and Efficient Catalyst for the One-Pot Green Synthesis of Benzimidazole Derivatives at Room Temperature

“…Evaporation of the solvent gave the crude product, which was purified by column chromatography over silica gel (n-hexane:ethyl acetate, 5:1) to afford the corresponding benzimidazole. All of the compounds are known compounds which they were identified from their 1 H NMR spectroscopic data and by comparing their melting points with those reported in the literature [17][18][19][20]49,51,61,62,76,77].…”

Recyclable Nanocrystalline Copper Based on MoO3/SiO2 as an Efficient Catalyst for Acylation of Amines

“…From literature found that, condensation of o-phenylene diamine with acids or aldehydes over homogenous catalysts such as copper acetate and lead tetra acetate [20], zinc acetate [21], ammonium chloride [22], zinc chloride [23], ammonium bromide [24], copper hydroxide [25], fluoroboric acid [26], boric acid [27], zinc triflate [28], ceric ammonium nitrate [29], and nickel acetate [30] were studied. In acylation reaction transition metals used as catalyst namely palladium [31], rhodium [32], and ruthenium [33].…”