Polyethers isolated from the marine actinobacterium Streptomyces cacaoi inhibit autophagy and induce apoptosis in cancer cells

Khan, Nasar; Yılmaz, Sinem; Aksoy, Semiha Çetinel; Uzel, Ataç; Tosun, Çiğdem; Ballar, Petek; Bedir, Erdal

doi:10.1016/j.cbi.2019.04.035

Cited by 23 publications

(23 citation statements)

References 72 publications

(101 reference statements)

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“…Other bacteria overrepresented in OSCC include, for example, Mycoplasma salivarium , as well as genera Parvimonas and Dialister [ 10 , 20 ]. Contrary, Streptomyces have been reported to have a tumor-protective effect thanks to their capability to induce apoptosis of tumor cells [ 21 ].…”

Section: Oral Bacteria Associated With Oral Cancermentioning

confidence: 99%

“…Mechanisms of association of selected aerobic and anaerobic bacteria with tumors of the oral cavity are presented in Table 1 [ 4 , 9 , 15 , 16 , 17 , 18 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]; an overview of selected bacteria most frequently identified in association with OSCC is provided in Table S1 (Supplementary Materials) [ 12 , 13 , 14 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ].…”

Section: Oral Bacteria Associated With Oral Cancermentioning

confidence: 99%

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The Role of the Oral Microbiota in the Etiopathogenesis of Oral Squamous Cell Carcinoma

et al. 2021

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Dysbiosis in the oral environment may play a role in the etiopathogenesis of oral squamous cell carcinoma (OSCC). This review aims to summarize the current knowledge about the association of oral microbiota with OSCC and to describe possible etiopathogenetic mechanisms involved in processes of OSCC development and progression. Association studies included in this review were designed as case–control/case studies, analyzing the bacteriome, mycobiome, and virome from saliva, oral rinses, oral mucosal swabs, or oral mucosal tissue samples (deep and superficial) and comparing the results in healthy individuals to those with OSCC and/or with premalignant lesions. Changes in relative abundances of specific bacteria (e.g., Porphyromonas gingivalis, Fusobacterium nucleatum, Streptococcus sp.) and fungi (especially Candida sp.) were associated with OSCC. Viruses can also play a role; while the results of studies investigating the role of human papillomavirus in OSCC development are controversial, Epstein–Barr virus was positively correlated with OSCC. The oral microbiota has been linked to tumorigenesis through a variety of mechanisms, including the stimulation of cell proliferation, tumor invasiveness, angiogenesis, inhibition of cell apoptosis, induction of chronic inflammation, or production of oncometabolites. We also advocate for the necessity of performing a complex analysis of the microbiome in further studies and of standardizing the sampling procedures by establishing guidelines to support future meta-analyses.

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Section: Oral Bacteria Associated With Oral Cancermentioning

confidence: 99%

Section: Oral Bacteria Associated With Oral Cancermentioning

confidence: 99%

The Role of the Oral Microbiota in the Etiopathogenesis of Oral Squamous Cell Carcinoma

et al. 2021

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“…The previous studies on S. cacaoi revealed the presence of polyoxins (nucleoside peptide antibiotics) [7,8], macrocyclic benzenoid ansamycins, trienomycins [9], polyethers [10] and cyclic peptides [11].…”

Section: Previous Studiesmentioning

confidence: 99%

“…When the molecular identification evaluated with the phenotypical results, the isolate was identified as S. cacaoi, large-scale fermentation of which provided 4.53 g of ethyl acetate extract. As a continuation of our first study on S. cacaoi, which yielded polyether antibiotics [10], further purification studies were performed affording two benzodiazepine derivatives (Figure 1). The chemical shift of these carbons indicated that they were part of an ester or amide functional group.…”

Section: Present Studymentioning

confidence: 99%

Benzodiazepine Derivatives from Marine-Derived Streptomyces cacaoi 14CM034

Aksoy¹,

Küçüksolak²,

Uzel³

et al. 2021

Rec.Nat.Prod.

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7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1). Structural elucidation of the compounds was based on FTIR, 1D- (1H and 13C NMR), 2D-NMR (COSY, HMBC and NOESY) and HR-MS analyses. Compounds 1 and 2 exhibited notable antimicrobial activity. The presence of PBD derivatives in S. cacaoi was first demonstrated with this study.

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“…Khan et al have reported the isolation of three polyether antibiotics from the marine actinobacterium Streptomyces cacao , namely, arenaric acid , K41 A , and 29- O -methyl-K41 A [ 147 ]. These compounds possess anticancer properties which were demonstrated using human cervical carcinoma (HeLa), human prostate cancer (PC-3), human lung adenocarcinoma (A549), and human colorectal adenocarcinoma (CaCo-2) cells [ 147 ]. The effect of two of the isolated compounds on autophagy in cancer cell lines was also examined.…”

Section: Marine Compounds With a Non-validated Autophagy-modulatormentioning

confidence: 99%

Blue-Print Autophagy in 2020: A Critical Review

Dyshlovoy

2020

Marine Drugs

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Autophagy is an elegant and complex biological process that has recently attracted much attention from the scientific community. The compounds which are capable of control and modulation of this process have a promising potential as therapeutics for a number of pathological conditions, including cancer and neurodegenerative disorders. At the same time, due to the relatively young age of the field, there are still some pitfalls in the autophagy monitoring assays and interpretation of the experimental data. This critical review provides an overview of the marine natural compounds, which have been reported to affect autophagy. The time period from the beginning of 2016 to the middle of 2020 is covered. Additionally, the published data and conclusions based on the experimental results are re-analyzed with regard to the guidelines developed by Klionsky and colleagues (Autophagy. 2016; 12(1): 1–222), which are widely accepted by the autophagy research community. Remarkably and surprisingly, more than half of the compounds reported to be autophagy activators or inhibitors could not ultimately be assigned to either category. The experimental data reported for those substances could indicate both autophagy activation and inhibition, requiring further investigation. Thus, the reviewed molecules were divided into two groups: having validated and non-validated autophagy modulatory effects. This review gives an analysis of the recent updates in the field and raises an important problem of standardization in the experimental design and data interpretation.

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Polyethers isolated from the marine actinobacterium Streptomyces cacaoi inhibit autophagy and induce apoptosis in cancer cells

Cited by 23 publications

References 72 publications

The Role of the Oral Microbiota in the Etiopathogenesis of Oral Squamous Cell Carcinoma

The Role of the Oral Microbiota in the Etiopathogenesis of Oral Squamous Cell Carcinoma

Benzodiazepine Derivatives from Marine-Derived Streptomyces cacaoi 14CM034

Blue-Print Autophagy in 2020: A Critical Review

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