Polyesters with main and side chain phosphoesters as structural motives for biocompatible electrospun fibres

Abstract

The functionalisation of polymacrolactones with phosphoesters was achieved by thiol–ene coupling resulting in copolymers with modulated properties.

Enzymatic recycling of polymacrolactones

“…32,50 Nevertheless, these unsaturations give a chance for further functionalization via epoxidation or thiol–ene click chemistry widening their properties and applications. 29,50–54…”

Accelerating the end-to-end production of cyclic phosphate monomers with modular flow chemistry

“…[2][3][4] However, PPEs have recently gained a renewed interest from the academic community in light of their potential biomedical applications 5 such as drug delivery systems [6][7][8][9][10][11][12] and tissue engineering. [13][14][15][16][17] Synthetic PPEs are especially appealing for their tunable (bio)degradability and biocompatibility properties. 2,18 A convenient synthetic method to obtain PPEs involves the ring opening polymerization (ROP) of cyclic phosphate monomers (CPMs), which enables the preparation of high molecular weight materials with narrow polydispersities.…”

Covalently Bonded N-Acetylcysteine-polyester Loaded in PCL Scaffolds for Enhanced Interactions with Fibroblasts

“…The modification of a biomaterial with bioactive molecules can be performed to optimize its performance in biological media, adding physical and chemical properties that favor interactions with cell membrane proteins and/or improve its biodegradability behavior. , Thiol–ene click reactions are a class of reactions that are widely used for the functionalization of polymers for biomedical purposes, generating bioactive materials. This is a simple and adaptable methodology, frequently employed as a postpolymerization modification method in unsaturated polymers. − The incorporation of covalently modified polymers in blends for the production of biomaterials allows modulating its final properties, adjusting them to the desired application. , …”