Polyester Nanoparticles with Controlled Topography for Peroral Drug Delivery Using Insulin as a Model Protein
Ingrid Marie Heyns,
Meenakshi Arora,
Raghu Ganugula
et al.
Abstract:Receptor-mediated polyester drug delivery systems have
tremendous
potential for improving the clinical performance of existing pharmaceutical
drugs. Despite significant progress made in this area, it remains
unclear how and to what extent the polyester nanoparticle surface
topography would affect the in vitro, ex
vivo and in vivo performance of a drug,
and if there exists a correlation between in vitro and in vivo, as well as healthy versus pathophysiological
states. Herein, we report a systematic investigatio… Show more
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