Polyelectrolyte multilayers containing a tannin derivative polyphenol improve blood compatibility through interactions with platelets and serum proteins

Câmara, Paulo C.F. da; Madruga, Liszt Y. C.; Sabino, Roberta M.; Vlcek, Jessi; Balaban, Rosângela de Carvalho; Popat, Ketul C.; Martins, Alessandro F.; Kipper, Matt J.

doi:10.1016/j.msec.2020.110919

Cited by 31 publications

(24 citation statements)

References 76 publications

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“…[38] Based on these criteria, CMKC could be an excellent candidate material to be used as a substitute for KC in biomaterial fabrication for tissue engineering and regenerative medicine. [39,40] In this work, we produced biocompatible crosslinked nanofibers of poly(vinyl alcohol)/carboxymethyl-kappacarrageenan (PVA/CMKC) through electrospinning of an aqueous blend solution of both polymers, followed by thermal crosslinking of the nanofibers. An insoluble biomaterial was obtained through a green process, without the use of hazardous solvents or generation of hazardous waste.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Crosslinked Nanofibers of Poly(Vinyl Alcohol)/Carboxymethyl‐Kappa‐Carrageenan Produced by a Green Process

Madruga

Balaban

Popat

et al. 2020

Macromolecular Bioscience

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This study presents a new type of biocompatible nanofiber based on poly(vinyl alcohol) (PVA) and carboxymethyl‐kappa‐carrageenan (CMKC) blends, produced with no generation of hazardous waste. The nanofibers are produced by electrospinning using PVA:CMKC blends with ratios of 1:0, 1:0.25, 1:0.4, 1:0.5, and 1:0.75 (w/w PVA:CMKC) in aqueous solution, followed by thermal crosslinking. The diameter of the fibers is in the nanometer scale and below 300 nm. Fourier transform infrared spectroscopy shows the presence of the carboxyl and sulfate groups in all the fibers with CMKC. The nanofibers from water‐soluble polymers are stabilized by thermal crosslinking. The incorporation of CMKC improves cytocompatibility, biodegradability, cell growth, and cell adhesion, compared to PVA nanofibers. Furthermore, the incorporation of CMKC modulates phenotype of human adipose‐derived stem cells (ADSCs). PVA/CMKC nanofibers enhance ADSC response to osteogenic differentiation signals and are therefore good candidates for application in tissue engineering to support stem cells.

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Section: Introductionmentioning

confidence: 99%

Biocompatible Crosslinked Nanofibers of Poly(Vinyl Alcohol)/Carboxymethyl‐Kappa‐Carrageenan Produced by a Green Process

Madruga

Balaban

Popat

et al. 2020

Macromolecular Bioscience

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“…Then, the oxidized substrate can adsorb polycationic polymers. The LbL approach produces thin films and coatings with controlled thicknesses (often between 1 and 100 nm) by controlling the number of layers deposited on the solid substrate [ 153 , 154 , 155 , 156 , 157 ].…”

Section: Processing Polysaccharide-based Materials For Biomedical Applicationsmentioning

confidence: 99%

“…Compared to chitosan/heparin PEMs (10 layers), the Tanfloc/heparin PEMs (10 layers) deposited on oxidized glass support hemocompatible surfaces. The surface has antifouling properties by preventing blood serum protein (fibrinogen) adsorption and platelet adhesion and activation [ 154 ]. Figure 10 C shows that the Tanfloc/heparin PEM (10 layers) significantly avoids platelet adhesion compared to the chitosan/heparin PEM.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

et al. 2021

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Polysaccharide-based materials created by physical processes have received considerable attention for biomedical applications. These structures are often made by associating charged polyelectrolytes in aqueous solutions, avoiding toxic chemistries (crosslinking agents). We review the principal polysaccharides (glycosaminoglycans, marine polysaccharides, and derivatives) containing ionizable groups in their structures and cellulose (neutral polysaccharide). Physical materials with high stability in aqueous media can be developed depending on the selected strategy. We review strategies, including coacervation, ionotropic gelation, electrospinning, layer-by-layer coating, gelation of polymer blends, solvent evaporation, and freezing–thawing methods, that create polysaccharide-based assemblies via in situ (one-step) methods for biomedical applications. We focus on materials used for growth factor (GFs) delivery, scaffolds, antimicrobial coatings, and wound dressings.

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“…Classification of biopolymers. [59][60][61][62][63][64][65][66][67] reinforce their present bioactivities as well as produce new functional bioactivities. The hydrogels developed through chemical routes involve covalent bonds formation between used polymers through the process of free radical polymerization, [83,84] or graft copolymerization, [85] or radical copolymerization [86] etc.…”

Section: Synthesis Of Biopolymer Compositesmentioning

confidence: 99%

“…[180] To develop hemocompatible surfaces, cationic tannin derivate (TN) was used by Da-Câmara et al in order to fabricate polyelectrolyte multilayers using the chondroitin sulfate and glycosaminoglycans heparin. [67] Amphoteric TN is cationic, condensed derivative of tannin with resonance structures. The presence of catechol groups in TN is similar to those in mussel adhesive protein.…”

Section: Biocompatibility Of Biopolymersmentioning

confidence: 99%

Multifunctional Biopolymers‐Based Composite Materials for Biomedical Applications: A Systematic Review

2021

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Biopolymers are considered as a favorable group of substances with a broad array of applications, of which biomedical field stands out. The interesting features of biopolymers such as low‐cost, non‐cytotoxicity, hydrophilicity, biodegradation and biocompatibility make them promising and excellent feedstock to be used in implantable devices. The bounteous reactive functional groups in the backbone structure of polysaccharides and its derivatives could be utilized to develop hydrogels, nano‐composite and 3D scaffolds with appealing structures and desired features, leading to promising research attention towards biomedical fields. The present review describes the foremost properties as well as potential of different biopolymers, and their composites for application in implantable biomedical systems. This work may introduce readers about the comprehension of state‐of‐the‐art advances, real present challenges along with the future anticipation of eco‐friendly and biomimetic techniques for the modification of biopolymeric materials to improve their biomedical applications.

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Polyelectrolyte multilayers containing a tannin derivative polyphenol improve blood compatibility through interactions with platelets and serum proteins

Cited by 31 publications

References 76 publications

Biocompatible Crosslinked Nanofibers of Poly(Vinyl Alcohol)/Carboxymethyl‐Kappa‐Carrageenan Produced by a Green Process

Biocompatible Crosslinked Nanofibers of Poly(Vinyl Alcohol)/Carboxymethyl‐Kappa‐Carrageenan Produced by a Green Process

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

Multifunctional Biopolymers‐Based Composite Materials for Biomedical Applications: A Systematic Review

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