Polyelectrolyte Multilayer Films as a Potential Buccal Platform for Drug Delivery

Abstract

The goal of this research was to study the potential of polyelectrolyte multilayers as buccal dosage forms for drug delivery and to investigate how the properties of the drugs impact the overall performance of the delivery system. Multilayer films based on the polyelectrolyte interaction between casein and chitosan were developed using benzydamine, tolfenamic acid and betahistine as model drugs. The samples were characterized for surface pH, moisture content and moisture absorption, swelling behavior and mucoadhesion. Additionally, surface morphology was investigated, as well as the drugs’ physical state after incorporation in the multilayer films. The samples proved to be non-irritant (pH was within the physiological range), physically stable (moisture content and moisture absorption below 5%) and mucoadhesive, adsorbing from 60 to 70% mucin. The release behavior corelated to the swelling index profiles of the samples and was strongly dependent on the drug solubility. The developed multilayer films appeared to be an optimum delivery system for sparingly soluble drugs due to the high drug loading achieved.

Biodegradable Local Chemotherapy Platform with Prolonged and Controlled Release of Doxorubicin for the Prevention of Local Tumor Recurrence

“…Thus, from day 30 to day 93, drug release was fairly linear with a coefficient of determination of 0.9938 and was approximately 3 ng/cm 2 per week. The initial explosive release may be the result of rapid swelling of the polymer mesh and may also be due to a change in pH between the assembly and release conditions, leading to rearrangement of polyelectrolytes in the coating and an increase in the number of voids. , The authors of some studies report that chitosan-based multilayer films have a high swelling ratio. , A multilayer film of 40 bilayers of poly-γ-glutamic acid and chitosan showed swelling up to 116 ± 14%. The resulting voids, in turn, initiate diffusion of the release medium into the coating and exchange with the surrounding counterions.…”

“…Explosive and short-term release has been observed in the multilayer platform assemblies, where the drug is loaded from a physical mixture with a polycation or polyanion. , To increase the stability and controlled release of the drug, we have created an ionic conjugate of poly-γ-glutamic acid and DOX, which acts as a complex polyanion in the assembly of the coating. Thus, in this paper, we report the platform assembly with the most prolonged DOX release of the existing platform creation studies. − This work also discusses the development of local chemotherapy platforms with different deposition structures to study the parameters affecting the release profile and to obtain the most uniform release kinetics of DOX.…”

In Vitro Anticancer Activity of Mucoadhesive Oral Films Loaded with Usnea barbata (L.) F. H. Wigg Dry Acetone Extract, with Potential Applications in Oral Squamous Cell Carcinoma Complementary Therapy

“…The moisture content affects the mucoadhesive film’s physical stability, preventing them from being brittle. The film has retained water due to the plasticizer hygroscopic attributes, and less than 5% moisture loss is required for better physical strength [ 94 ]. As expected, UBA inclusion in the polymer matrix does not considerably change the humidity content of the film.…”

Spray-Dried Chitosan Hydrogel Particles as a Potential Delivery System for Benzydamine Hydrochloride

“…The ability of the obtained three types of particles to bind mucin was evaluated by the Bradford colorimetric method, according to previously reported protocol [ 41 ]. Namely, 20 mg of each type of sample was mixed with 2 mL mucin solution in water (0.5 mg/mL) for 2 h. The presented values are average out of three measurements with standard deviations included.…”