Polyelectrolyte Complexes Based on Chitosan and Natural Polymers

Mustafa, Alef; Tomescu, Aneta; Mustafa, Emin; Cherim, Melat; Sîrbu, Rodica

doi:10.26417/ejis.v4i1.p100-107

Cited by 5 publications

(5 citation statements)

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“…Recently, the utility of carrageenans in drug delivery systems has been demonstrated, whereby carrageenans were used as gellingor viscosity-enhancing agents for controlled drug release systems with applications in tissue regeneration using therapeutic biomacromolecules (Guan, Li, & Mao, 2017;Li et al, 2014). Chitosan-carrageenan polyelectrolyte complexes are available, which can be used as excipients for various dosage forms (Mustafa, Tomescu, Mustafa, Cherim, & Sîrbu, 2016).…”

Section: Carrageenan: Structure and Biological Activitiesmentioning

confidence: 99%

Nutraceutical Potential of Seaweed Polysaccharides: Structure, Bioactivity, Safety, and Toxicity

Tanna

Mishra

2019

Comp Rev Food Sci Food Safe

223

123

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In recent years, marine organisms including seaweeds have been highlighted as potential sources of useful metabolites and bioactive compounds, with vast biological and physiological activities. Seaweeds have long been used as a food source, for medicinal purposes, and as dietary supplements in various Asian countries, and their potential benefits have recently attracted the attention of many Western and European countries. Their commercial value depends on their applications in the food, nutraceutical, and pharmaceutical industries. Seaweeds are considered a potential source of nutraceuticals or functional foods, and analysis of taste‐oriented motives has revealed that seaweeds are preferentially selected over other types of marine foods by seafood consumers and people with high levels of health, education, and living status. It is a general perception that health conscious people prefer environmentally friendly food sources, and present an opportunity to focus on seaweed‐based foods, which have significant nutritional benefits to humans. Among the various bioactive constituents, seaweed polysaccharides have been proven to possess various beneficial properties including anticoagulant, anti‐inflammatory, antioxidant, anticarcinogenic, and antiviral activities. The diversity and composition of seaweed polysaccharides play vital roles in these biological activities. Seaweeds are a rich source of sulfated polysaccharides, which are responsible for much of the bioactivity, as they can interact with various textures and cellular proteins. A number of toxicological assays and clinical trials suggest that the ingestion of seaweeds as functional foods should be considered worldwide to improve immune responses. In this review, different polysaccharides from seaweeds and their compositions and potential nutraceutical applications are discussed.

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Section: Carrageenan: Structure and Biological Activitiesmentioning

confidence: 99%

Nutraceutical Potential of Seaweed Polysaccharides: Structure, Bioactivity, Safety, and Toxicity

Tanna

Mishra

2019

Comp Rev Food Sci Food Safe

223

123

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“…The understanding and control of the degradation rate of chitin and chitosan-based devices is of great interest since degradation is essential in many small and large molecule releaseapplications and in functional tissue regeneration applications. Ideally, the rate of scaffold degradation should mirror the rate of new tissue formation or be adequate for the controlled release of bioactive molecules (Mustafa A., 2016). Thus, it is important to understand and control both the mechanism and the rate by which each material is degraded.…”

Section: Biological Properties Of Chitosan Biodegradabilitymentioning

confidence: 99%

“…In the 1970s it has been demonstrated that CHOS have anti-tumor effects, and reduce metastasis from tumors (Mustafa A., 2016). Initially it was believed that the antitumor activity was due to the cationic properties of CHOS, and later, the MW was discovered to play a major role.…”

Section: Tumor Growth Inhibitionmentioning

confidence: 99%

“…The bone marrow is formed from the mesenchymal stem cells that are able to differentiate into chondrocytes, adipocytes and osteoblasts. Bone-tissue is mainly formed from bone matrix and osteoblasts (Mustafa A., 2015;Mustafa A., 2016). CHOS and chitosan are able to increase the differentiation of mesenchymal stem cells to osteoblasts and to facilitate the formation of bone-tissue.…”

Section: Increased Bone Strengthmentioning

confidence: 99%

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Studies on Chitosan, Chitin and Chitooligosaccharides and Their Biomedical Properties

Ibram

2021

European Journal of Natural Sciences and Medicine

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Research in healthcare involves the use of natural resources in the manufacture of pharmaceutical products. Chito-oligosaccharides (CHOS) are described as homo- or heterooligomers of N-acetylglucosamine and D-glucosamine. As a starting material for CHOS production chitin or chitosan can be used. When it comes to the medical field, there are indications that CHOS may be developed and used as drugs against asthma, antibacterial agents, ingredients in wound-dressings and vectors in gene-therapy. The methods of production can rely on enzymatic conversions, chemical methods or combinations of these methods. There is ample literature concerning the biological effects of chitosans, but relatively little is known about the effects of CHOS, and the mechanisms behind observed bioactivities are generally poorly understood. This review is focused on the characterization of chitin and chitosan by presenting the biological properties, and on the enzymatic production of CHOS, and on further separation and purification methods for producing well-defined mixtures and also provides an overview of some of the most promising applications of CHOS.

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“…However, being a polysaccharide, chitosan needs to be cross-linked with a plethora of different molecules [ 15 , 16 , 17 , 18 ] to allow dimensional stability to be achieved in an aqueous environment, which is fundamental in the reusing process of the solid biocatalyst. Among them alginate, a linear unbranched polymer containing β-(1→4)-linked D-mannuronic acid and α-(1→4)-linked L-guluronic acid [ 19 ], is one of the most used [ 20 , 21 ]. Anyway, even when cross-linked, natural polymers can be prone to swelling and degradation, especially under harsh operating conditions, which may lead to the loss of enzyme activity and reduced lifespan of the immobilized enzymes.…”

Section: Introductionmentioning

confidence: 99%

Design of a 3D Amino-Functionalized Rice Husk Ash Nano-Silica/Chitosan/Alginate Composite as Support for Laccase Immobilization

et al. 2023

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Recycling of agro-industrial waste is one of the major issues addressed in recent years aimed at obtaining products with high added value as a future alternative to traditional ones in the per-spective of a bio-based and circular economy. One of the most produced wastes is rice husk and it is particularly interesting because it is very rich in silica, a material with a high intrinsic value. In the present study, a method to extract silica from rice husk ash (RHA) and to use it as a carrier for the immobilization of laccase from Trametes versicolor was developed. The obtained mesoporous nano-silica was characterized by X-ray diffraction (XRD), ATR-FTIR spectroscopy, Scanning Elec-tron Microscopy (SEM), and Energy Dispersive X-ray spectroscopy (EDS). A nano-silica purity of about 100 % was found. Nano-silica was then introduced in a cross-linked chitosan/alginate scaffold to make it more easily recoverable after reuse. To favor laccase immobilization into the composite scaffold, functionalization of the nano-silica with (γ-aminopropyl) triethoxysilane (APTES) was performed. The APTES/RHA nano-silica/chitosan/alginate (ARCA) composite al-lowed to obtain under mild conditions (pH 7, room temperature, 1.5 h reaction time) a robust and easily reusable solid biocatalyst with 3.8 U/g of immobilized enzyme which maintained 50 % of its activity after six reuses. The biocatalytic system, tested for syringic acid bioremediation, was able to totally oxidize the contaminant in 24 h.

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Polyelectrolyte Complexes Based on Chitosan and Natural Polymers

Cited by 5 publications

References 0 publications

Nutraceutical Potential of Seaweed Polysaccharides: Structure, Bioactivity, Safety, and Toxicity

Nutraceutical Potential of Seaweed Polysaccharides: Structure, Bioactivity, Safety, and Toxicity

Studies on Chitosan, Chitin and Chitooligosaccharides and Their Biomedical Properties

Design of a 3D Amino-Functionalized Rice Husk Ash Nano-Silica/Chitosan/Alginate Composite as Support for Laccase Immobilization

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