Polyelectrolyte Behavior of Astramol Poly(propyleneimine) Dendrimers

Kabanov, V.A.; Зезин, А. Б.; Rogacheva, V. B.; Gulyaeva, Zh. G.; Zansochova, M. F.; Joosten, J. G. H.; Brackman, J.

doi:10.1021/ma971643a

Cited by 95 publications

(81 citation statements)

References 3 publications

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“…Acid base titration of the aqueous solutions of the P4 can be seen in Fig.1. Figure 2 shows the predicted extent of protonation (α) values of tertiary and primary amine groups of P4 dendrimer in aqueous solutions within the pH range of 2-12. These values were calculated by using Hendersen-Hasselbech equation (1) with the calculated pKa values on Table 2 [17]. (1) where α is extent of protonation, pKa is the acidity constants for tertiary and primary amine groups, and pH is the measurement of the hydronium ion concentration of the aqueous media.…”

Section: Potentiometric Measurementsmentioning

confidence: 99%

Characterization of Co(II)-PAMAM dendrimer complexes with polypropylene oxide core by using UV-VIS spectroscopy

Ertürk

Gürbüz

Tülü

et al. 2016

Maced. J. Chem. Chem. Eng.

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The aim of this study was to characterize poly(amidoamine) (PAMAM) dendrimer complexes of Co(II) ions by using UV-Vis spectroscopy. For this aim, a generation-4 polypropylene oxide (Jeffamine ® T-403) cored and amine-terminated PAMAM dendrimer (P4) was used as a model complexation agent. Optimum complexation condition for P4 was determined by potentiometric and spectroscopic titration studies. Extent of protonation (EOP) of the amino groups of P4 was determined from the potentiometric titration data and validated with spectroscopic titration data. The results indicated that pH 8 was the optimum dendrimer aqueous solution media, where the available number of tertiary amines present in P4 was the highest for possible metal complexation. At the optimized conditions, UV-Vis characterization of the Co(II)-P4 complexes was performed and 585-635 nm d-d transition bands were observed as the characteristic complexation bands of the tertiary amine groups of P4 with Co(II) ions. Obtained Co(II)-P4 complexes might be considered for the development of magnetic resonance image (MRI) improvers or MRI contrast agents.Keywords: PAMAM dendrimer; Jeffamine; complexation; UV-Vis spectroscopy; MRI contrast agents КАРАКТЕРИЗАЦИЈА НА PAMAM-ДЕНДРИМЕРНИ КОМПЛЕКСИ НА Co(II) СО ПРОПИЛЕН-ОКСИДЕН КОСТУР СО КОРИСТЕЊЕ НА UV-VIS СПЕКТРОСКОПИЈАЦелта на ова истражување е да се карактеризираат поли(амидоамински) (PAMAM) дендримерни комплекси на јоните на Co(II) со помош на UV-Vis спектроскопија. За таа цел беа користени полипропилено оксиден костур од генерацијата-4 (Jeffamine ® T-403) и амински терминиран PAMAM дендример (P4) како модел за средство за комплексирање. Оптималните услови за P4 беа определени со помош на потенциометриски и спектроскопски титрациски испитувања. Степенот на протонирање (EOP) на аминогрупите на P4 беше определен со потенциометриски титрации, кои потоа беа валидирани со спектроскопски титрации. Резултатите укажуваат дека оптимален медиум се водни раствори со рН 8 кога достапниот број на терцијарни амини присутни во P4 беше највисок за можно комплексирање на металот. Во оптимизираните услови беше извршена UV-Vis карактеризација на комплексите на Co(II)-P4. Беа регистрирани 585-635 nm d-d транзициски ленти како карактеристични комплексирачки ленти на терцијарните амински групи на P4 со јоните на Co(II). Добиените комплекси на Co(II)-P4 можат да се земат предвид за развивање на подобрувачи на магнетно резонатни слики (MRI) и како контрастни средства за MRI.Клучни зборови: PAMAM дендримери; комплексирање; UV-Vis спектроскопија; контрастни средства за MRI A. Serol Ertürk, M. Ulvi Gürbüz, M. Tülü, A. Emin Bozdoğan Maced.

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Section: Potentiometric Measurementsmentioning

confidence: 99%

Characterization of Co(II)-PAMAM dendrimer complexes with polypropylene oxide core by using UV-VIS spectroscopy

Ertürk

Gürbüz

Tülü

et al. 2016

Maced. J. Chem. Chem. Eng.

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“…As demonstrated by Kabanov and colleagues [16], one of the advantages of this dendrimer is that it binds to DNA via electrostatic interactions involving only the peripheral amine groups, leaving the tertiary amine groups in the dendrimer free to act as a "proton sponge" in the endosome. We recently demonstrated that Tf-bearing DAB dendriplex (average size: 287 nm) resulted in gene expression mainly in the tumors after intravenous administration [17].…”

Section: Recent Use Of Transferrin-bearing Dendrimers For Cancer Therapymentioning

confidence: 99%

Transferrin-Bearing Dendrimers for Cancer Therapy: an Update

Somani

Dufès

2015

Nanomedicine (Lond.)

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“…However, not all the functional groups are available for interaction due to steric volume, molecule rotation or stereochemistry effects. Dendrimers can have positive and negative charges, which allows them to complex different types of drugs [89]. …”

Section: Dendrimersmentioning

confidence: 99%

“…The nature of liposomes makes them one of the best alternatives for drug delivery because they are non-toxic and remain inside the bloodstream for a long time [130][131][132][133]. Nevertheless, some factors affect the degree of transdermal drug penetration such as the lamellarity, the lipid composition, the charge on the liposomal surface, the mode of application and the total lipid concentrations [89,134]. For that reason, flexible vesicles called transfersomes or transformable liposomes have been compared with those rigid vesicles to enhance penetration [135][136][137][138][139][140][141][142].…”

Section: -Phase Inversion Temperaturementioning

confidence: 99%

Nanocarrier Systems for Transdermal Drug Delivery

Escobar-Chávez¹,

Rodríguez-Cruz²,

Domínguez-Delgado³

et al. 2012

Recent Advances in Novel Drug Carrier Systems

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is an open discussion, in one hand, the nanotechnologist continue making new and more sophisticated nanocarriers and in the other hand, toxicologist continue evaluating possible damaging effects.Whatever it happens, nanotechnology is the new era and nanomedicine cannot be taking off. New nanocarriers will be created and the entire scientist working in nanomedicine bet for it to be the cure of diseases that in this moment are difficult to deal with [3] The application of preparations to the skin for medical purposes is as old as the history of medicine itself, with references to the use of ointments and salves found in the records of Babylonian and Egyptian medicine. The historical development of permeation research is well described by Hadgraft & Lane [4]. Over time, the skin has become an important route for drug delivery in which topical, regional or systemic effects are desired. Nevertheless, skin constitutes an excellent barrier and presents difficulties for the transdermal delivery of therapeutic agents, since few drugs possess the characteristics required to permeate across the stratum corneum in sufficient quantities to reach a therapeutic concentration in the blood. In order to enhance drug transdermal absorption different methodologies have been investigated developed and patented [5,6]. Improvement in physical permeationenhancement technologies has led to renewed interest in transdermal drug delivery. Some of these novel advanced transdermal permeation enhancement technologies include: iontophoresis, electroporation, ultrasound, microneedles to open up the skin and more recently the use of transdermal nanocarriers [3,[7][8][9][10].A number of excellent reviews that have been published contain detailed discussions concerning many aspects of transdermal nanocarriers [11][12][13][14][15][16][17]. The present chapter shows an updated overview of the use of submicron particles and other nanostructures in the pharmaceutical field, specifically in the area of topical and transdermal drugs. This focus is justified due to the magnitude of the experimental data available with the use of these nanocarriers. The development of submicron particles and other nanostructures in the pharmaceutical and cosmetic fields has been emerged in the last decades for designing best formulations for application through the skin [18][19][20][21]. The skinThe skin is the largest organ of the body [22][23][24], accounting for more than 10% of body mass, and the one that enables the body to interact more intimately with its environment. Essentially, the skin consists of four layers: The SC, that is the outer layer of the skin (nonviable epidermis), and forms the rate-controlling barrier for diffusion for almost all compounds. It is composed of dead flattened, keratin-rich cells, the corneocytes. These dense cells are surrounded by a complex mixture of intercellular lipids, namely, ceramides, free fatty acids, cholesterol, and cholesterol sulphate. Their most important feature is that they are structured as ordered bilayer arrays [25]...

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Polyelectrolyte Behavior of Astramol Poly(propyleneimine) Dendrimers

Cited by 95 publications

References 3 publications

Characterization of Co(II)-PAMAM dendrimer complexes with polypropylene oxide core by using UV-VIS spectroscopy

Characterization of Co(II)-PAMAM dendrimer complexes with polypropylene oxide core by using UV-VIS spectroscopy

Transferrin-Bearing Dendrimers for Cancer Therapy: an Update

Nanocarrier Systems for Transdermal Drug Delivery

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