Polyelectrolyte-based solid dispersions for enhanced dissolution and pH-Independent controlled release of sildenafil citrate

Woo, Ju-Hyeong; Ngo, Hai V.; Nguyen, Hy D.; Gil, Myung-Chul; Park, Chulhun; Park, Jun-Bom; Cui, Jing-Hao; Cao, Qing-Ri; Lee, Beom-Jin

doi:10.1016/j.heliyon.2023.e23091

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e23091

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Polyelectrolyte-based solid dispersions for enhanced dissolution and pH-Independent controlled release of sildenafil citrate

Ju-Hyeong Woo,

Hai V. Ngo,

Hy D. Nguyen

et al.

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2024

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Solid Dispersions Obtained by Ball Milling as Delivery Platform of Etodolac, a Model Poorly Soluble Drug

Czajkowska-Kośnik,

Misztalewska-Turkowicz,

Wilczewska

et al. 2024

Materials

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Poor water solubility of drugs is a limiting factor for their bioavailability and pharmacological activity. Many approaches are known to improve drug solubility, and among them, the physical method, solid dispersions (SDs), is applied. SDs are physical mixtures of a drug and a carrier, sometimes with the addition of a surfactant, which can be obtained by milling, cryomilling, spray-drying, or lyophilization processes. In this study, solid dispersions with etodolac (ETD-SDs) were prepared by the milling method using different carriers, such as hypromellose, polyvinylpyrrolidone, copovidone, urea, and mannitol. Solubility studies, dissolution tests, morphological assessment, thermal analysis, and FTIR imaging were applied to evaluate the SD properties. It was shown that the ball-milling process can be applied to obtain SDs with ETD. All designed ETD-SDs were characterized by higher water solubility and a faster dissolution rate compared to unprocessed ETD. SDs with amorphous carriers (HPMC, PVP, and PVP/VA) provided greater ETD solubility than dispersions with crystalline features (urea and mannitol). FTIR spectra confirmed the compatibility of ETD with tested carriers.

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Solid Dispersions Obtained by Ball Milling as Delivery Platform of Etodolac, a Model Poorly Soluble Drug

Czajkowska-Kośnik,

Misztalewska-Turkowicz,

Wilczewska

et al. 2024

Materials

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show abstract

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Polyelectrolyte-based solid dispersions for enhanced dissolution and pH-Independent controlled release of sildenafil citrate

Cited by 1 publication

References 26 publications

Solid Dispersions Obtained by Ball Milling as Delivery Platform of Etodolac, a Model Poorly Soluble Drug

Solid Dispersions Obtained by Ball Milling as Delivery Platform of Etodolac, a Model Poorly Soluble Drug

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