Polydopamine/puerarin nanoparticle-incorporated hybrid hydrogels for enhanced wound healing

Advanced wound scaffolds that integrate active substances to treat chronic wounds have gained significant recent attention. While wound scaffolds and advanced functionalities have previously been incorporated into one medical device, the wirelessly triggered release of active substances has remained the focus of many research endeavors. To combine multiple functions including light-triggered activation, antiseptic, angiogenic, and moisturizing properties, a 3D printed hydrogel patch encapsulating vascular endothelial growth factor (VEGF) decorated with photoactive and antibacterial tetrapodal zinc oxide (t-ZnO) microparticles is developed. To achieve the smart release of VEGF, t-ZnO is modified by chemical treatment and activated through ultraviolet/ visible light exposure. This process would also make the surface rough and improve protein adhesion. The elastic modulus and degradation behavior of the composite hydrogels, which must match the wound healing process, are adjusted by changing t-ZnO concentrations. The t-ZnO-laden composite hydrogels can be printed with any desired micropattern to potentially create a modular elution of various growth factors. The VEGF-decorated t-ZnO-laden hydrogel patches show low cytotoxicity and improved angiogenic properties while maintaining antibacterial functions in vitro. In vivo tests show promising results for the printed wound patches, with less immunogenicity and enhanced wound healing.

show abstract

“…The wound healing process was monitored by an optical microscope and a confocal microscope for up to two weeks. [ 54 ]…”

Section: Methodsmentioning

confidence: 99%

Light‐Controlled Growth Factors Release on Tetrapodal ZnO‐Incorporated 3D‐Printed Hydrogels for Developing Smart Wound Scaffold

Siebert

Luna‐Cerón

García‐Rivera

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…The administration of FA reduces oxidative stress and DNA damage caused by lead acetate [ 42 ]. In our previous study, we showed that the hydrogel incorporated with PUE exerted excellent antioxidant effects, which promoted the regeneration and healing of damaged skin [ 43 ]. In the present study, we found that PUE and FA have a synergistic role in resisting oxidative stress damage in vitro and promoting wound healing in vivo .…”

Section: Resultsmentioning

confidence: 99%

More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing

Zhang

et al. 2021

J Nanobiotechnol

Self Cite

View full text Add to dashboard Cite

Background During wound healing, the overproduction of reactive oxygen species (ROS) can break the cellular oxidant/antioxidant balance, which prolongs healing. The wound dressings targeting the mitigation of ROS will be of great advantages for the wound healing. puerarin (PUE) and ferulic acid (FA) are natural compounds derived from herbs that exhibit multiple pharmacological activities, such as antioxidant and anti-inflammatory effects. Polydopamine (PDA) is made from natural dopamine and shows excellent antioxidant function. Therefore, the combination of natural antioxidants into hydrogel dressing is a promising therapy for wound healing. Results Hydrogel wound dressings have been developed by incorporating PUE or FA via PDA nanoparticles (NPs) into polyethylene glycol diacrylate (PEG-DA) hydrogel. This hydrogel can load natural antioxidant drugs and retain the drug in the gel network for a long period due to the presence of PDA NPs. Under oxidative stress, this hydrogel can improve the activity of superoxide dismutase and glutathione peroxidase and reduce the levels of ROS and malondialdehyde, thus preventing oxidative damage to cells, and then promoting wound healing, tissue regeneration, and collagen accumulation. Conclusion Overall, this triple antioxidant hydrogel accelerates wound healing by alleviating oxidative injury. Our study thus provides a new way about co-delivery of multiple antioxidant natural molecules from herbs via antioxidant nanoparticles for wound healing and skin regeneration. Graphic Abstract

show abstract

“…In Figure S1a (Supporting Information), the MICH matrix exhibited extremely rapid water absorption capacity within the first 100 min and yielded a swelling saturation ratio of up to 2269%, implying that the MICH may quickly absorb tissue exudate and leaked blood when it applied to wound beds. [ 31 ] Generally, high molecular weight (MW) hyaluronan (HA) plays a significant biological activity in the tissue microenvironment, while low MW‐HA causes inflammation and tissue fibrosis. [ 32 ] In Figure S1b (Supporting Information), the degradation ratio of MICH showed relatively stable trends within 10 days, indicating the MICH matrix may maintain the structural integrity of high MW‐HA in PBS, facilitating the anti‐inflammatory effects of HA on wound tissue.…”

Section: Resultsmentioning

confidence: 99%

Injectable Enzyme‐Based Hydrogel Matrix with Precisely Oxidative Stress Defense for Promoting Dermal Repair of Burn Wound

Zhang

Wang

Sun

et al. 2020

Macromolecular Bioscience

View full text Add to dashboard Cite

Burn wound healing remains a challenging health problem worldwide due to the lack of efficient and precise therapy. Inherent oxidative stress following burn injury is importantly responsible for prolonged inflammation, fibrotic scar, and multiple organ failure. Herein, a bioinspired antioxidative defense system coupling with in situ forming hydrogel, namely, multiresponsive injectable catechol‐Fe3+ coordination hydrogel (MICH) matrix, is engineered to promote burn‐wound dermal repair by inhibiting tissue oxidative stress. This MICH matrix serves as the special traits of “Fe‐superoxide dismutases,” small molecular antioxidant (vitamin E), and extracellular matrix (ECM) in alleviating cellular oxidative damage, which demonstrates precise scavenging on reactive oxygen species (ROS) of different cellular locations, blocking lipid peroxidation and cell apoptosis. In in vivo burn‐wound treatment, this MICH promptly integrates with injured surrounding tissue to provide hydration microenvironment and physicochemical ECM for burn wounds. Importantly, the MICH matrix suppresses tissue ROS production, reducing the inflammatory response, prompting re‐epithelization and neoangiogenesis during wound healing. Meanwhile, the remodeling skin treated with MICH matrix demonstrates low collagen deposition and normal dermal collagen architecture. Overall, the MICH prevents burn wound progression and enhances skin regeneration, which might be a promising biomaterial for burn‐wound care and other disease therapy induced by oxidative stress.

show abstract

Polydopamine/puerarin nanoparticle-incorporated hybrid hydrogels for enhanced wound healing

Abstract: Oxidative damage generated would disrupt the oxidant/antioxidant balance in cells, causing slow wound healing and tissue regeneration. Hydrogel dressing with antioxidant properties can promote wound healing, however, its design is still a challenge.

Cited by 96 publications

References 39 publications

Light‐Controlled Growth Factors Release on Tetrapodal ZnO‐Incorporated 3D‐Printed Hydrogels for Developing Smart Wound Scaffold

Light‐Controlled Growth Factors Release on Tetrapodal ZnO‐Incorporated 3D‐Printed Hydrogels for Developing Smart Wound Scaffold

More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing

Injectable Enzyme‐Based Hydrogel Matrix with Precisely Oxidative Stress Defense for Promoting Dermal Repair of Burn Wound

Contact Info

Product

Resources

About