Polydopamine Nanocarriers with Cascade-Activated Nitric Oxide Release Combined Photothermal Activity for the Therapy of Drug-Resistant Bacterial Infections
Ting Cui,
Feiyang Xu,
Jun Wang
et al.
Abstract:Antibiotic abuse leads to increased bacterial resistance,
and the
surviving planktonic bacteria aggregate and secrete extracellular
polymers to form biofilms. Conventional antibacterial agents find
it difficult to penetrate the biofilm, remove the bacteria wrapped
in it, and produce an excellent therapeutic effect. In this study,
a dual pH- and NIR-responsive nanocomposite (A-Ca@PDA) was developed
to remove drug-resistant bacteria through a cascade of catalytic nitric
oxide (NO) release and photothermal cleara… Show more
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