Polydopamine modified TiO2 nanotube arrays as a local drug delivery system for ibuprofen

Li, Lifen; Xie, Chunling; Xiao, Xiufeng

doi:10.1016/j.jddst.2020.101537

Cited by 25 publications

(15 citation statements)

References 17 publications

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“…Some simple anti-inflammatory drugs (e.g., ibuprofen) have been used as model molecules to demonstrate the versatility of MNP as drug-delivery nano-agents. Li et al, for example, fabricated PDA coated TiO 2 nanotube arrays (TNTs) via the ultrasonic method as drug-releasing materials for local drug delivery [ 144 ]. The presence of PDA in the PDA-modified TNTs was demonstrated to be crucial as it significantly enhanced the drug loading capacity and biomineralization ability of the TNTs, as well as it encouraged the nucleation of hydroxyapatite on the surface of samples.…”

Section: Mnp Based Therapy and Theranosticsmentioning

confidence: 99%

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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Bioinspired nanomaterials are ideal components for nanomedicine, by virtue of their expected biocompatibility or even complete lack of toxicity. Natural and artificial melanin-based nanoparticles (MNP), including polydopamine nanoparticles (PDA NP), excel for their extraordinary combination of additional optical, electronic, chemical, photophysical, and photochemical properties. Thanks to these features, melanin plays an important multifunctional role in the design of new platforms for nanomedicine where this material works not only as a mechanical support or scaffold, but as an active component for imaging, even multimodal, and simple or synergistic therapy. The number of examples of bio-applications of MNP increased dramatically in the last decade. Here, we review the most recent ones, focusing on the multiplicity of functions that melanin performs in theranostics platforms with increasing complexity. For the sake of clarity, we start analyzing briefly the main properties of melanin and its derivative as well as main natural sources and synthetic methods, moving to imaging application from mono-modal (fluorescence, photoacoustic, and magnetic resonance) to multi-modal, and then to mono-therapy (drug delivery, anti-oxidant, photothermal, and photodynamic), and finally to theranostics and synergistic therapies, including gene- and immuno- in combination to photothermal and photodynamic. Nanomedicine aims not only at the treatment of diseases, but also to their prevention, and melanin in nature performs a protective action, in the form of nanopigment, against UV-Vis radiations and oxidants. With these functions being at the border between nanomedicine and cosmetics nanotechnology, recently examples of applications of artificial MNP in cosmetics are increasing, paving the road to the birth of the new science of nanocosmetics. In the last part of this review, we summarize and discuss these important recent results that establish evidence of the interconnection between nanomedicine and cosmetics nanotechnology.

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Section: Mnp Based Therapy and Theranosticsmentioning

confidence: 99%

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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“…[116] The ample amount of research study related to biomedical applications of titanium oxide based functional hybrid materials has been reported. [117,118] TiNPs function hybrid materials applications are not only limited towards few sectors of the biomedical fields but explored in many arenas comprising Photo-therapy [119] for cancer, Drug delivery structure, [120,121] Bioimaging, [122] Biosensors. [123] Although their reach in the biomedical sector is phenomenal but still have an excellent opportunity in current research for antiviral application.…”

Section: Titanium Nanoparticles (Tinps)mentioning

confidence: 99%

Nanotechnology‐Based Approach to Combat Pandemic COVID 19: A Review

Shukla

Tyagi

Bhandari

et al. 2021

Macromolecular Symposia

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The emergence of a novel Corona virus (COVID 19) originated on December 19 from China. The city of Wuhan, the capital city of Hubei province, China, is responsible for an outbreak of respiratory illness known as COVID 19 and it has been rapidly spread across the world claiming millions of lives. The sudden outbreak of novel Coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2 or 2019‐nCoV), is a big concern for their speedy mitigation using the predictable treatment and creating its approach around the world. Researchers and doctors are in search of rapid diagnosis kit, drugs, and viral‐resistant personal protective equipment (PPE) to clinical diagnosis, medication, and prevent the spread of COVID 19. A rational approach with adaptability and broad viewpoint to challenge the growing pain could be overcome by the application of appropriate technology. The nanotechnology‐based approach can significantly serve the purpose of the current pandemic situation of COVID 19. But same time implementation of innovative and creative nanotech approach, there is a decisive need for the full knowledge of SARS‐CoV‐2 pathogenesis. Moreover, to defeat COVID 19, particularly nanotech‐based system with their viral inhibitory properties to increase the effective nanotech approach is essential. In this scenario, this review aims to summarize the past, present, and future of nanotech‐based systems that can be used to treat COVID 19, highlighting Nano‐based compounds. Lastly, the potential application of the different category of Inorganic Nanomaterials/Inorganic organic conjugate /hybrid system and their practical applicability as suitable means for inspiring against COVID 19 has also been discussed.

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“…Conform studiilor de specialitate, nanoparticulele de aur pot ajuta în tratamentul hepatitei de tip C oferind o eficacitate sporită și prelungită a tratamentul cu interferon a (Lee M, Yang J, 2012). Dioxidul de titan împreună cu ibuprofenul îmbunătățește abilitatea biomi-neralizării în terapia post implant de oase (Li, Xie and Xiao, 2020).…”

Section: Ii4 Nanofarmaceuticeleunclassified

Perspective ale nanotehnologiilor în medicină | [Perspectives of nanotechnologies in medicine]

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2021

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Nanotechnology is defined as the branch that deals with the development of nanoparticles with physical and chemical properties with applicability in various industrial and medical fields. Due to their properties, nanoparticles can also be used in medical practice in the development of new types of testing and diagnosis both in vivo and in vitro. For in vitro testing, it is desired to develop chips that contain several sensors to detect quantitatively and qualitatively various biochemical parameters (the concept of 'lab on a chip'). For in vivo testing, nanoparticles are used in both imaging and cancer therapy. In addition, nanoparticles have prospects in advancing implant technology and sensors/biosensors (e.g. blood glucose values; real-time detection). Nanopharmaceuticals are used to administrate targeted pharmacological agents to certain organs and cells (cell selectivity). The implementation of these techniques/devices provides a need to respect the associated ethical aspects. Rezumat Nanotehnologia studiază dezvoltarea unor nanoparticule cu proprietăți fizice și chimice cu aplicabilitate în diverse domenii industriale, dar și medicale. Datorită proprietăților lor, nanoparticulele pot fi utilizate și în practica medicală în dezvoltarea unor tipuri noi de testare și diagnostic atât in vivo, cât și in vitro. In cadrul testărilor in vitro se dorește dezvoltarea unor cipuri care să conțină mai mulți senzori pentru a detecta cantitativ și calitativ diverși analiți biochimici (conceptul de “lab on a chip”). In cadrul testărilor in vivo nanoparticulele sunt folosite atât în imagistică, cât și în terapia cancerului. Nanoparticulele oferă perspective speciale pentru tehnologia implanturilor și a senzorilor/biosenzorilor (ex detecția în timp real a glicemiei). Nanofarmaceuticele sunt utilizate pentru administrarea unor agenți farmacologici țintit spre anumite organe și celule (selectivitate celulară). Implementarea acestor tehnici/device-uri trebuie să respecte aspectele etice asociate.

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Polydopamine modified TiO2 nanotube arrays as a local drug delivery system for ibuprofen

Cited by 25 publications

References 17 publications

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Nanotechnology‐Based Approach to Combat Pandemic COVID 19: A Review

Perspective ale nanotehnologiilor în medicină | [Perspectives of nanotechnologies in medicine]

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