Polydopamine-carbon dots functionalized hollow carbon nanoplatform for fluorescence-imaging and photothermal-enhanced thermochemotherapy

Lu, Junya; Wang, Kaili; Lei, Wei; Mao, Yuling; Di, Donghua; Zhao, Qinfu; Wang, Siling

doi:10.1016/j.msec.2021.111908

Cited by 35 publications

(17 citation statements)

References 53 publications

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“…Lee’s group modified quantum dots with a polydopamine outer layer to increase the stability of nanoparticles . Wang’s group solved the problem of fluorescence quenching of porous carbon based on the Förster resonance energy transfer (FRET) by loading carbon dots on the surface of the PDA layer . However, few studies have been focused on improving the photothermal performance of polydopamine by conjugating near-infrared sensitive quantum dots.…”

Section: Introductionmentioning

confidence: 99%

“…37 Wang's group solved the problem of fluorescence quenching of porous carbon based on the Forster resonance energy transfer (FRET) by loading carbon dots on the surface of the PDA layer. 38 However, few studies have been focused on improving the photothermal performance of polydopamine by conjugating near-infrared sensitive quantum dots. In this study, N,S-doped carbon quantum dots (N,S-CQDs) were loaded on the surface of polyethylenimine (PEI)functionalized PDA through EDC-NHS reaction (PDA-PEI@N,S-CQDs), and it is the first report showing that carbon quantum dots could directly enhance the photothermal behavior of PDA nanoparticles by surface chelation.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced Photothermal Performance by Carbon Dot-Chelated Polydopamine Nanoparticles

Shu

Liu

Chang

et al. 2021

ACS Biomater. Sci. Eng.

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Polydopamine (PDA) has been widely used in biomedical applications including imaging contrast agents, antioxidants, UV protection, and photothermal therapy due to its biocompatibility, metal-ion chelation, free-radical scavenging, and wideband absorption, but its low photothermal efficiency still needs to be improved. In this study, we chelated near-infrared (NIR) sensitive carbon quantum dots on the surface of polydopamine (PDA-PEI@N,S-CQDs) to increase its near-infrared absorption. Surprisingly, although only 4% (w/w) of carbon quantum dots was conjugated on the PDA surface, it still increased the photothermal efficiency by 30%. Moreover, PDA-PEI@N,S-CQDs could also be used as the drug carrier for loading 60% (w/w) of the DOX and achieved stimuli-responsive drug release under lysosomal pH (pH 5.0) and 808 nm laser illumination. For in vitro therapeutic experiment, PDA-PEI@N,S-CQDs showed the remarkable therapeutic performance under 808 nm laser irradiation for killing 90% of cancer cells compared with 50% by pure PDA nanoparticles, and the efficacy was even higher after loading DOX owing to the synergistic effect by photothermal therapy and chemotherapy. This intelligent and effective therapeutic nanosystem based on PDA-PEI@N,S-CQDs showed enhanced photothermal behavior after chelating carbon dots and promoted the future development of a nanoplatform for stimuli-responsive photothermal/chemo therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhanced Photothermal Performance by Carbon Dot-Chelated Polydopamine Nanoparticles

Shu

Liu

Chang

et al. 2021

ACS Biomater. Sci. Eng.

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“…In the case of the fluorescence enhancement, we attributed it to the disappearance of the aggregation-caused quenching (ACQ) effect, which is common in CDs. [78][79][80] After the disintegration of ZCD, the distance between the CDs increased, which weakened the ACQ effect.…”

Section: Ph-responsiveness Of Zcdmentioning

confidence: 99%

ZIF-based carbon dots with lysosome-Golgi transport property as visualization platform for deep tumour therapy via hierarchical size/charge dual-transform and transcytosis

Zhang

Jiang

et al. 2022

Nanoscale

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“…However, most CDs usually absorb light in the short wavelength region due to the π-π* transition of the C=C bond; therefore, other nanomaterials, such as metal nanoparticles ( 132 ) or semiconducting polymers ( 133 ) are needed as NIR-assisted PTAs ( 131 ). Lu et al ( 42 ) assembled polydopamine (PDA) and carbon points on hollow mesoporous carbon (HMC) to construct a photothermal enhanced multi-functional system (HMC-SS-PDA@CDs). The results of in vivo experiments showed that under low-power, 808-nm laser radiation of 0.75 W/cm 2 , the antitumor drug-loaded HMC-SS-PDA@CDs inhibited tumor growth by 92.6% and significantly reduced the toxicity of Dox to cells, indicating that Dox/HMC-SS-PDA@CD nanoparticles have good photothermal chemotherapeutic synergism and ideal biocompatibility.…”

Section: Classification Of Photothermal Nanomaterialsmentioning

confidence: 99%

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

et al. 2022

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The aggressive growth of cancer cells brings extreme challenges to cancer therapy while triggering the exploration of the application of multimodal therapy methods. Multimodal tumor therapy based on photothermal nanomaterials is a new technology to realize tumor cell thermal ablation through near-infrared light irradiation with a specific wavelength, which has the advantages of high efficiency, less adverse reactions, and effective inhibition of tumor metastasis compared with traditional treatment methods such as surgical resection, chemotherapy, and radiotherapy. Photothermal nanomaterials have gained increasing interest due to their potential applications, remarkable properties, and advantages for tumor therapy. In this review, recent advances and the common applications of photothermal nanomaterials in multimodal tumor therapy are summarized, with a focus on the different types of photothermal nanomaterials and their application in multimodal tumor therapy. Moreover, the challenges and future applications have also been speculated.

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Polydopamine-carbon dots functionalized hollow carbon nanoplatform for fluorescence-imaging and photothermal-enhanced thermochemotherapy

Cited by 35 publications

References 53 publications

Enhanced Photothermal Performance by Carbon Dot-Chelated Polydopamine Nanoparticles

Enhanced Photothermal Performance by Carbon Dot-Chelated Polydopamine Nanoparticles

ZIF-based carbon dots with lysosome-Golgi transport property as visualization platform for deep tumour therapy via hierarchical size/charge dual-transform and transcytosis

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

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