Polydopamine-based nanomedicines for efficient antiviral and secondary injury protection therapy

Yin, Na; Zhang, Zhongmou; Ge, Yongzhuang; Zhao, Yongxing; Gu, Zichen; Yang, Yue; Mao, Lu; Wei, Zhanyong; Liu, Junjie; Shi, Jinjin; Wang, Zhenya

doi:10.1126/sciadv.adf4098

Cited by 13 publications

(1 citation statement)

References 52 publications

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“…Several reports are on the antitumor effects of BP-based drug delivery systems. − However, these nanocarriers are primarily loaded with small-molecule drugs and nucleotides instead of bioactive macromolecules. In addition, polydopamine is most widely used for drug delivery applications, including photothermal and targeted therapies. − Nevertheless, immunotherapy and PTT can synergistically inhibit tumor cells using multiple mechanisms, such as improving ferroptosis for synergistic photothermal-IDO immunotherapy. , …”

Section: Introductionmentioning

confidence: 99%

Cordyceps sinensis Polysaccharide Loaded on Black Phosphorus for Synergistic Immunotherapy and Photothermal Therapy of Cancer

Wang,

Chen,

et al. 2024

ACS Appl. Nano Mater.

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Cordyceps sinensis is a valuable Chinese medicine, possessing multiple bioactive compounds with diverse pharmacological effects. The extracts of C. sinensis, especially the polysaccharide fraction, can suppress the proliferation of different tumor cells, induce apoptosis, and stimulate antitumor immune responses. However, C. sinensis polysaccharides (CSP) have yet to be characterized, with a rare reporting of their effective doses. Immunotherapy depends on harnessing the inherent ability of the immune system to recognize and eliminate tumor cells. Polarizing the anti-inflammatory M2 tumor-associated macrophages (TAMs) to the pro-inflammatory M1 phenotype is an effective antitumor immunotherapy strategy. We designed a drug delivery system with black phosphorus (BP) nanosheets loaded with CSP for synergistic antitumor photothermal therapy (PTT) and immunotherapy. The BP/CSP@PDA−PEG-FA nanoparticles (NPs) enhanced the polarization of M2 macrophages to the M1 phenotype in vitro and in vivo. Moreover, the NPs inhibited the growth of 4T1 xenografts upon near-infrared (NIR) laser stimulation by causing photothermal ablation of tumor cells and promoting T cellmediated antitumor immune responses. Therefore, BP/CSP@PDA−PEG-FA NPs are a promising platform for combined PTT and immunotherapy for breast tumors.

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Section: Introductionmentioning

confidence: 99%

Cordyceps sinensis Polysaccharide Loaded on Black Phosphorus for Synergistic Immunotherapy and Photothermal Therapy of Cancer

Wang,

Chen,

et al. 2024

ACS Appl. Nano Mater.

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An All‐in‐One Nano‐Biomimetic Polyamidoamine Dendrimer Platform for Treatment of CRKP Pneumonia

Duan,

Li,

Wang

et al. 2024

Adv Funct Materials

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Polymyxin B (PMB) is often considered as the last line of defense for treating carbapenem‐resistant Klebsiella pneumoniae (CRKP). However, its efficacy is hindered by limited penetration across the blood‐air barrier in the lung due to its low lipid solubility. To simultaneously increase PMB in epithelial lining fluid while suppressing the excessive inflammatory response in the lung, a novel nano‐biomimetic system “Siv‐PMB@G4@MM” is designed and fabricated by encapsulating PMB‐ and anti‐inflammatory Sivelestat (Siv)‐loaded G4 PAMAM dendrimers with macrophage membranes (MM). The Siv‐PMB@G4@MM displayed a superior acidic pH‐responsive release property and can target inflamed lung tissues, greatly increasing the concentrations of PMB and Siv at the infection site. Compared with free drugs, Siv‐PMB@G4@MM demonstrated superior synergistic antibacterial and anti‐inflammatory activities. Moreover, due to the ability of MM to sequester lipopolysaccharide (LPS) and some pro‐inflammatory cytokines, Siv‐PMB@G4@MM further enhanced the anti‐inflammatory potential of Siv. In mouse models of LPS‐induced acute lung injury, pulmonary bacterial infection, and sepsis‐induced pneumonia, Siv‐PMB@G4@MM significantly reduced inflammatory responses and/or bacterial burdens, mitigated neutrophil infiltration and pulmonary edema, and decreased neutrophil extracellular trap (NET) secretion. The highly improved biocompatibility and efficiency of the multifunctional Siv‐PMB@G4@MM presents a promising strategy for the clinical treatment of antibiotic‐resistant bacterial pneumonia.

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Bioactive Nanofiber‐Hydrogel Composite Regulates Regenerative Microenvironment for Skeletal Muscle Regeneration after Volumetric Muscle Loss

Yu,

Zhang,

et al. 2024

Adv Healthcare Materials

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Volumetric muscle loss (VML) is a severe form of muscle trauma that exceeds the regenerative capacity of skeletal muscle tissue, leading to substantial functional impairment. The abnormal immune response and excessive reactive oxygen species (ROS) accumulation hinder muscle regeneration following VML. Here, we engineered an interfacial cross‐linked hydrogel‐poly(ε‐caprolactone) nanofiber composite that incorporates both biophysical and biochemical cues to modulate the immune and ROS microenvironment for enhanced VML repair. The interfacial cross‐linking was achieved through a Michael addition between catechol and thiol groups. The resultant composite exhibited enhanced mechanical strength without sacrificing porosity. Moreover, it mitigated oxidative stress and promoted macrophage polarization toward a pro‐regenerative phenotype, both in vitro and in a mouse VML model. Four weeks post‐implantation, mice implanted with the composite showed improved grip strength and walking performance, along with increased muscle fiber diameter, enhanced angiogenesis, and more nerve innervation compared to control mice. Collectively, these results suggest that the interfacial cross‐linked nanofiber‐hydrogel composite could serve as a cell‐free and drug‐free strategy for augmenting muscle regeneration by modulating the oxidative stress and immune microenvironment at the VML site.This article is protected by copyright. All rights reserved

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Polydopamine-based nanomedicines for efficient antiviral and secondary injury protection therapy

Cited by 13 publications

References 52 publications

Cordyceps sinensis Polysaccharide Loaded on Black Phosphorus for Synergistic Immunotherapy and Photothermal Therapy of Cancer

Cordyceps sinensis Polysaccharide Loaded on Black Phosphorus for Synergistic Immunotherapy and Photothermal Therapy of Cancer

An All‐in‐One Nano‐Biomimetic Polyamidoamine Dendrimer Platform for Treatment of CRKP Pneumonia

Bioactive Nanofiber‐Hydrogel Composite Regulates Regenerative Microenvironment for Skeletal Muscle Regeneration after Volumetric Muscle Loss

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