Polydopamine-based molecular imprinted optic microfiber sensor enhanced by template-mediated molecular rearrangement for ultra-sensitive C-reactive protein detection

Liu, Xin; Lin, Wenfu; Xiao, Peng; Yang, Mingjin; Sun, Li-Peng; Zhang, Yi; Wang, Xue; Guan, Bai‐Ou

doi:10.1016/j.cej.2020.124074

Cited by 41 publications

(19 citation statements)

References 40 publications

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“…In addition, the detection of a particular biomarker at very low concentrations is not only challenging, but also time-consuming [2]. Current methods of detection include enzyme-linked immunosorbent assays (ELISA), surface plasmon resonance (SPR) spectroscopy, surface enhanced Raman spectroscopy and fluorescence-based detection [2][3][4][5][6][7][8]. Amongst these, SPR presents the most advanced label-free and real-time biomarker detection capability [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

SPR Biosensor Based on Polymer Multi-Mode Optical Waveguide and Nanoparticle Signal Enhancement

Walter

Eilers

Alwis

et al. 2020

Sensors

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We present a surface plasmon resonance (SPR) biosensor that is based on a planar-optical multi-mode (MM) polymer waveguide structure applied for the detection of biomolecules in the lower nano-molar (nM) range. The basic sensor shows a sensitivity of 608.6 nm/RIU when exposed to refractive index changes with a measurement resolution of 4.3 × 10−3 RIU. By combining the SPR sensor with an aptamer-functionalized, gold-nanoparticle (AuNP)-enhanced sandwich assay, the detection of C-reactive protein (CRP) in a buffer solution was achieved with a response of 0.118 nm/nM. Due to the multi-mode polymer waveguide structure and the simple concept, the reported biosensor is well suited for low-cost disposable lab-on-a-chip applications and can be used with rather simple and economic devices. In particular, the sensor offers the potential for fast and multiplexed detection of several biomarkers on a single integrated platform.

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Section: Introductionmentioning

confidence: 99%

SPR Biosensor Based on Polymer Multi-Mode Optical Waveguide and Nanoparticle Signal Enhancement

Walter

Eilers

Alwis

et al. 2020

Sensors

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“…Liu and co-workers developed an optical micro-fibre interferometer with molecularly imprinted PDA receptor for detecting C-reactive protein (CRP). The sensor was capable of quantifying CRP down to 581.3 zg mL −1 which was 8 times lower than conventional sandwich ELISA [169]. Reproduced with permission from [165,167,170,171].…”

Section: Evanescent Wave-based Sensors For Biomedical Diagnosticsmentioning

confidence: 99%

Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

Altıntaş

2020

Micromachines

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In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

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“…Furthermore, molecularly imprinted fibrous monoliths tend to exhibit high binding capacities, low detection limits, fast response times, mechanical stability, and so on. In this regard, various fibrous monoliths obtained from, for example, polymers, ceramics, or carbon allotropes have been widely used along with electrospun mats or papers. − In contrast, fibrous, microporous monoliths can exhibit large effective surface areas and enhanced adsorption–desorption kinetics, yet they have seldom been investigated due to their synthetic complexity . In this conceptual study, hierarchically designed fibrous, microporous monoliths could be easily obtained without using any substrate via a bottom–up approach.…”

Section: Introductionmentioning

confidence: 99%

Hierarchical Design of Functional, Fibrous, and Microporous Polymer Monoliths for the Molecular Recognition of Diethylstilbestrol

et al. 2021

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This paper demonstrates the hierarchical design of functional, fibrous polymer monoliths. The monoliths are composed of conjugated microporous polymers that not only are embedded with heteroatoms but also feature fibrous yet compressible structures due to the in situ self-assembly process that occurs during the polymerization process. Therefore, the doped nitrogen atoms can allow the growth of zeolitic imidazolate framework (ZIF) nanocrystals, which causes the homogeneous encapsulation of individual fibers. The resulting hybrid monoliths exhibit enhanced physical properties as well as catalytic activity, allowing the formation of an additional coating layer via a thiol−epoxy reaction. The deliberate inclusion of template molecules during the reaction forms molecularly imprinted sites on the fibers to afford functional monoliths. As a proof of concept, the hierarchically designed materials are able to show effective recognition properties toward diethylstilbestrol, an endocrine disruptor, taking advantage of the binding sites that selectively capture the analyte molecules and the fibrous morphology that increases the accessibility of these binding sites. We envisage that the incorporation of various heteroatoms or nanocrystals will bring about the bespoke design of advanced monoliths with autonomous functions, leading to smart textile systems.

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Polydopamine-based molecular imprinted optic microfiber sensor enhanced by template-mediated molecular rearrangement for ultra-sensitive C-reactive protein detection

Cited by 41 publications

References 40 publications

SPR Biosensor Based on Polymer Multi-Mode Optical Waveguide and Nanoparticle Signal Enhancement

SPR Biosensor Based on Polymer Multi-Mode Optical Waveguide and Nanoparticle Signal Enhancement

Recent Progress in Optical Sensors for Biomedical Diagnostics

Hierarchical Design of Functional, Fibrous, and Microporous Polymer Monoliths for the Molecular Recognition of Diethylstilbestrol

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