Polydopamine as an Efficient Polymer to Prepare Biologically Relevant Supported Lipid Bilayers

Abstract

This nuclear plasticity, measured as projected nuclear area fluctuations, showed a non-monotonous relation to actin polymerization state. Also, myosin contractility was determined to be necessary for such nucleus plasticity. The effect of cytoskeletal organization and their active forces on chromatin plasticity was further quantified by tracking the dynamics of condensed chromatin regions, which showed increased dynamics corresponding to enhanced nuclear plasticity. In summary, using cells of defined geometries to specify cytoskeletal organization, our work demonstrates the role of active cytoskeletal forces in regulating nuclear and chromatin plasticity.