Polydimethylsiloxane and poly(ether) ether ketone functionally graded composites for biomedical applications

Smith, James A.; Mele, Elisa; Rimington, Rowan P.; Capel, Andrew J.; Lewis, Mark P.; Silberschmidt, Vadim V.; Li, Simin

doi:10.1016/j.jmbbm.2019.02.012

Cited by 24 publications

(12 citation statements)

References 95 publications

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“…This mass loss showed the thermal "unzip-degradation" depolymerization of PDMS, corresponding to the dissociation of Si-O-Si bonds and the subsequent formation of cyclic siloxanes of varying chain lengths. Furthermore, there was a negligible weight loss when the temperature rose above 542°C (<3%) (Smith et al, 2019).…”

Section: Results and Discussion Characterizationsmentioning

confidence: 99%

Removal of carbol fuchsin from aqueous solution by using three‐dimensional porous, economic, and eco‐friendly polymer

Tarhan

2021

Water Environment Research

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Water resources are the main source of life for living beings on Earth. The world population is growing rapidly, and the need for clean water resources is increasing. Conventional water resources such as rivers, lakes, groundwater, etc., are being exploited to meet freshwater demand. In recent years, environmental pollutants have become one of the most important problems due to their toxic effects on human life and the

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Section: Results and Discussion Characterizationsmentioning

confidence: 99%

Removal of carbol fuchsin from aqueous solution by using three‐dimensional porous, economic, and eco‐friendly polymer

Tarhan

2021

Water Environment Research

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“…The materials that have been utilized for orthopedic implants or medical applications include metals, such as stainless steel, cobalt-chrome, and titanium alloys, 126 polymers (ultrahigh-molecular-weight polyethylene, poly (ether-ether-ketone), 127,128 and ceramics (hydroxyapatite). 129 However, during recent decades, there has been a shift from the use of biostable biocompatible materials to bioabsorbable or biodegradable biomaterials for medical devices used to repair and regenerate tissue damage.…”

Section: Industrial Applications Of Green Compositesmentioning

confidence: 99%

Green composites and their contribution toward sustainability: A review

Vázquez-Núñez

Avecilla-Ramírez

Vergara-Porras

et al. 2021

Polymers and Polymer Composites

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The current world environment scenario demands new and more eco-friendly solutions to global problems that cover the demands for materials. This sector has included green polymer-based composites and natural reinforcers from origins of renewable sources, these Green Composites (GC), natural-fiber-reinforced bio-composites in which the matrix is a bio-based polymer, have shown attractive characteristics. Biodegradability is one of the most important attributes for these new “green” materials, in that this characteristic allows for their introduction into the world market as an environmental solution. The manufacturing processes for obtaining these materials have observed important improvements because each raw material exhibits different properties and characteristics and their eco-friendly character has facilitated its incorporation into diverse sectors, such as construction, automotive, packaging, and medicine, among others. At present, this segment represents an important income for some economies, especially those where these resources are available, enhancing the creation of green economies, strengthening the world’s efforts toward sustainability.

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“…PDMS is a widely used material in biomedical applications such as implants, devices, and cellular studies because of its nontoxicity and biocompatibility properties. [33][34][35][36][37] PDMS possesses favorable unique properties as it is permeable to gases, chemically inert, thermally stable, rigid, and optically clear. [38][39][40][41] Lai and Liu 32 and Huang et al 30 have fabricated cubic eggshells made of PDMS with an internal egg-shaped feature in the former model but not in the latter.…”

Section: Glass Bowl Glass Bowl With Clear Lid Angiogenesis and Vasculmentioning

confidence: 99%

“…[33][34][35][36][37] PDMS possesses favorable unique properties as it is permeable to gases, chemically inert, thermally stable, rigid, and optically clear. More recently, polydimethylsiloxane (PDMS) has been utilized to form the culture vessels.…”

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confidence: 99%

Bioengineered three‐dimensional transparent eggshell as a chicken embryo experimentation platform for biomedical research

Ishak

Chan

Ang

et al. 2020

Engineering Reports

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The chicken embryo is widely used as an experimental model in the areas of regenerative medicine, tumor biology, and angiogenesis. Eggshell opacity and rigidity present restricted three-dimensional (3D) viewing and accessibility to the embryo and its circulatory network despite egg windowing. The ability to engineer an eggshell, which eliminates the opacity yet provides 3D access for manipulation is beneficial and would potentially make it enticing for the use of chicken embryo as a cheaper alternative vertebrate model.Here, we present the feasibility of fabricating a morphologically analogous transparent chicken eggshell made of polydimethylsiloxane using a biaxial rotation computer-controlled bioreactor to achieve uniform thickness. By culturing chicken embryo in the bioengineered eggshell, we demonstrated success in meeting developmental milestones and its practicality as an experimental platform by visualizing both embryo and vasculature development using common laboratory imaging tools. Although the viability of the embryo in the bioengineered eggshell was lower than in the normal egg, this was attributed to the absence of calcium source. The bioengineered eggshell, in its initial stage of development, provides a platform to be used to investigate beyond gross observations of the embryo and vascular network in 3D optical clarity and its imaging capabilities has the potential to be extended to other imaging modalities. We have developed a transparent ex ovo eggshell, biomimicking the elliptical geometry to address the lack of 3D optical clarity contributed by the eggshell opacity.This retains the natural shape that may support the development of the chicken embryo and allows easy access to the embryo, its circulatory system and respective organ development in far reaching applications. K E Y W O R D Sbioengineering, chicken embryo, fabrication, imaging, rotation moldingThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.The use of chicken embryo as an experimental model confers several advantages over other vertebrate models. It is a unique model, which allows relatively easy access to the embryo and its circulatory system, rendering the possibility for embryo manipulation and monitoring of the chicken embryo development from blastoderm formation until hatching. The chicken embryo is an inexpensive model with a relatively short embryonic development of 21 days. 1,2 In addition, they are ethically acceptable, only requiring animal ethics approval if hatching is expected. Moreover, its amenability to xenografting due to its naturally immunodeficient system in the first 2 weeks of development allows cell transplantation and cell tracking without rejection, rendering it an attractive model widely used in tumor biology, angiogenesis, and regenerative medicine studies. 3-11 These embryo manipulations and visualizati...

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Polydimethylsiloxane and poly(ether) ether ketone functionally graded composites for biomedical applications

Cited by 24 publications

References 95 publications

Removal of carbol fuchsin from aqueous solution by using three‐dimensional porous, economic, and eco‐friendly polymer

Removal of carbol fuchsin from aqueous solution by using three‐dimensional porous, economic, and eco‐friendly polymer

Green composites and their contribution toward sustainability: A review

Bioengineered three‐dimensional transparent eggshell as a chicken embryo experimentation platform for biomedical research

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