Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: A new proposal for bone tissue repair

Guizzardi, Stefano; Galli, Carlo; Govoni, Paolo; Boratto, Renata; Cattarini, G.; Martini, Désirèe; Belletti, Silvana; Scandroglio, R

doi:10.1016/s0024-3205(03)00547-2

Cited by 73 publications

(86 citation statements)

References 36 publications

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“…This leads to an increase in the number of fibroblasts (35%) and in the production of all the components of the dermal matrix (30%): collagenous and non-collagenous proteins, hyaluronic acid, elastin, fibronectin, and so on. [30,31,32]. …”

Section: Discussionmentioning

confidence: 99%

Genital Lichen Sclerosus in Male Patients: A New Treatment with Polydeoxyribonucleotide

Zucchi¹,

Cai²,

Cavallini³

et al. 2016

Urol Int

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Lichen sclerosus (LS) is an inflammatory and chronic disease that causes itching, pain, dysuria, urinary retention, dyspareunia and sexual dysfunction, in both men and women. The first line pharmacological treatment is based on the use of topical steroids, which have proved their efficacy in 60-70% of cases but with a high rate of relapses in time (50-80% of the patients of both sexes). The purpose of our non-randomised prospective pilot study was to evaluate the efficacy and tolerability of a new loco regional therapy with polydeoxyribonucleotides (PDRN) in the treatment of male genital LS. PDRN is an healing and anti-dystrophic drug with anti-inflammatory effects, through the reduction of cytokine. Twenty one male patients suffering from genital LS were recruited. All the patients were submitted to treatment using loco-regional intradermal injections with PDRN. Dermatology Life Quality Index (DLQI), International Index of Erectile Function (IIEF-5) and PGI-I questionnaires were administered at baseline and at the end of treatment in order to evaluate the results of this treatment. The statistical evaluation of the data obtained with the DLQI questionnaire showed a marked improvement of the overall conditions in terms of quality of life, with an average change of scores from 15 to 4 (p < 0.0001). PGI-I questionnaire showed that 80% of the patients treated considered their post-treatment conditions as ‘improved'. There was no significant change in terms of sexual function according to the IIEF questionnaire (p = 0.189). The results obtained show the excellent tolerability and the therapeutic efficacy of PDRN, with clear improvement of the local symptoms and of the quality of life.

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Section: Discussionmentioning

confidence: 99%

Genital Lichen Sclerosus in Male Patients: A New Treatment with Polydeoxyribonucleotide

Zucchi¹,

Cai²,

Cavallini³

et al. 2016

Urol Int

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“…However, many of these graft materials lack osteoinductive potential (an exception being autogenous bone), despite possessing good biocompatibility and osteoconductive potential; their osteogenic potential is unsatisfactory. Much research has thus focused on graft materials mixed with additives, such as bone morphogenetic protein (BMP; a protein with osteoinductive potential) or fibroblast differentiation promoting factor, which may secure a material with excellent osteogenic potential 1,2) . Since 1965, Urist first extracted BMP from decalcified bone matrix 3) , more than 20 types of osteoinductive protein have been discovered worldwide.…”

Section: Introductionmentioning

confidence: 99%

Effects of Demineralized Dentin Matrix Used as an rhBMP-2 Carrier for Bone Regeneration

Kim

et al. 2014

J. Hard Tissue Biology.

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The purpose of this study was to evaluate the DDM as a carrier of recombinant human BMP-2 (rhBMP-2). In the study 1, the rhBMP-2 was fixed to inorganic bovine bones, tricalcium phosphate (TCP), DDM powder, and DDM chip. Over a period of 36 days, the amount of rhBMP-2 released was analyzed. In the study 2, the expression of protein markers by rhBMP-2 combined with DDM was evaluated in mice at 1, 2 and 4 weeks. In the control group (n=20 mice), 20 μg grafts of TCP+rhBMP-2 (concentration=0.05 mg/ml) were applied, while in the experimental group (n=20 mice), 20 μg grafts of DDM powder+rhBMP-2 (concentration=0.05 mg/ml) were applied. In the study 1, the slow release of rhBMP-2 was exhibited by all four graft types throughout the 36-day, a statistically significant large amount of rhBMP-2 was released from the DDM powder compared to the other materials (p<0.05). In the study 2, the expression of osteonectin was found to be limited to adjacent areas of TCP in the control group, however, it was observed in the DDM in the experimental group. The experimental group exhibited significant mature bone formation in the 4th week, but not in the 1st week of the experiment. Within limited research in this study DDM powder appears to have great potential as an effective scaffold for rhBMP-2. In the DDM powder+rhBMP-2, new bone formation was evidently shown and the amount of released rhBMP-2 was the highest. It was proposed that DDM powder might be an effective carrier of rhBMP-2.

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“…PDRN is helpful for normal matrix formation by shortening the healing period through its prompt tissue regeneration and wound healing and by promoting the creation of collageneous/ noncollageneous protein. Also, it is characterized by being effective in tissue regeneration by promoting cell regeneration in cellular stage [9][10][11][12][13][14] . In 2008, an autogenous bone graft material was developed from extracted teeth, and subjected to many basic and clinical studies.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Autogenous Tooth Bone Graft Combined with Growth Factor: Prospective Cohort Study

Ahn¹,

Kim²,

Yun³

et al. 2013

Journal of Korean Dental Science

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Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: A new proposal for bone tissue repair

Cited by 73 publications

References 36 publications

Genital Lichen Sclerosus in Male Patients: A New Treatment with Polydeoxyribonucleotide

Genital Lichen Sclerosus in Male Patients: A New Treatment with Polydeoxyribonucleotide

Effects of Demineralized Dentin Matrix Used as an rhBMP-2 Carrier for Bone Regeneration

Effectiveness of Autogenous Tooth Bone Graft Combined with Growth Factor: Prospective Cohort Study

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