Polydatin protects the respiratory system from PM2.5 exposure

Abstract

Atmospheric particle is one of the risk factors for respiratory disease; however, their injury mechanisms are poorly understood, and prevention methods are highly desirable. We constructed artificial PM2.5 (aPM2.5) particles according to the size and composition of actual PM2.5 collected in Beijing. Using these artificial particles, we created an inhalation-injury animal model. These aPM2.5 particles simulate the physical and chemical characteristics of the actual PM2.5, and inhalation of the aPM2.5 in rat results in a time-dependent change in lung suggesting a declined lung function, injury from oxidative stress and inflammation in lung. Thus, this aPM2.5-caused injury animal model may mimic that of the pulmonary injury in human exposed to airborne particles. In addition, polydatin (PD), a resveratrol glucoside that is rich in grapes and red wine, was found to significantly decrease the oxidative potential (OP) of aPM2.5 in vitro. Treating the model rats with PD prevented the lung function decline caused by aPM2.5, and reduced the level of oxidative damage in aPM2.5-exposed rats. Moreover, PD inhibited aPM2.5-induced inflammation response, as evidenced by downregulation of white blood cells in bronchoalveolar lavage fluid (BALF), inflammation-related lipids and proinflammation cytokines in lung. These results provide a practical means for self-protection against particulate air pollution.

The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal

“…Actually, several in vivo studies have reported an important protective role of polydatin treatment via different mechanisms in ovalbumin-induced bronchial asthma as well as in LPS-induced acute lung injury [212,213]. Moreover, polydatin protects the respiratory system from the damage caused by fine particulate matters (aerodynamic diameter < 2.5 μm; PM2.5) during air pollution that may cause deleterious effects such as premature death among individuals due to lung disease, lung dysfunction and asthma exacerbation, mainly by the capacity of polydatin to reduce the injury from oxidative stress and inflammation in lung tissues [214]. Moreover, polydatin can attenuate hypoxic pulmonary hypertension through Protein Kinase C Mechanisms (PKC) and it might be a promising candidate for hypoxic pulmonary treatment [215].…”

Polydatin prevents bleomycin‑induced pulmonary fibrosis by inhibiting the TGF‑&beta;/Smad/ERK signaling pathway

“…Thanks to these properties, polydatin is frequently used for treating health-related disorders such as cardiac disabilities ( 20 ), various carcinomas ( 21 , 22 ), hepatitis ( 23 ) and hepatic fibrosis ( 24 ). It can also significantly reduce lipopolysaccharide-induced lung injury ( 25 ), protect against PM2.5-induced respiratory system diseases ( 26 ) and alleviate reactive oxygen species (ROS)- and bleomycin (BLM)-induced EMT and pulmonary fibrosis ( 27 , 28 ).…”

Polydatin suppresses nucleus pulposus cell senescence, promotes matrix homeostasis and attenuates intervertebral disc degeneration in rats

“…Polydatin (PD), a resveratrol glucoside, is abundant in different daily nourishment such as red wines, grapes as well as cocoa-containing products. 15,16 Despite the identification of diverse beneficial functions of resveratrol (RSV) (eg anti-inflammation, antioxidant and anti-ageing), RSV does not exert favourable pharmacological properties because of its quick clearance rate and poor oral bioavailability. 17,18 Therefore, it is essential to search novel molecules that have extensive pharmacological protective effects beyond RSV.…”