Polydatin and its potential protective effect on COVID-19

Bonucci, Massimo; Raggi, Roberto; Vacca, Rosa Anna

doi:10.1016/j.clnu.2020.09.052

Cited by 9 publications

(8 citation statements)

References 7 publications

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“…From the current picture, PD emerges as a potential candidate drug/protective agent, which can act as a sort of "biological mask". It can inhibit the binding of Spike to ACE2 and therefore reduce viral entry into host cells, also being well-known its favourable properties like high water solubility and metabolic stability, good oral absorption and absence of side effects, as well as beneficial and protective effects during inflammation particularly of the respiratory tract [87].…”

Section: Discussionmentioning

confidence: 99%

Interference of Polydatin/Resveratrol in the ACE2:Spike Recognition during COVID-19 Infection. A Focus on Their Potential Mechanism of Action through Computational and Biochemical Assays

et al. 2021

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In the search for new therapeutic strategies to contrast SARS-CoV-2, we here studied the interaction of polydatin (PD) and resveratrol (RESV)—two natural stilbene polyphenols with manifold, well known biological activities—with Spike, the viral protein essential for virus entry into host cells, and ACE2, the angiotensin-converting enzyme present on the surface of multiple cell types (including respiratory epithelial cells) which is the main host receptor for Spike binding. Molecular Docking simulations evidenced that both compounds can bind Spike, ACE2 and the ACE2:Spike complex with good affinity, although the interaction of PD appears stronger than that of RESV on all the investigated targets. Preliminary biochemical assays revealed a significant inhibitory activity of the ACE2:Spike recognition with a dose-response effect only in the case of PD.

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Section: Discussionmentioning

confidence: 99%

Interference of Polydatin/Resveratrol in the ACE2:Spike Recognition during COVID-19 Infection. A Focus on Their Potential Mechanism of Action through Computational and Biochemical Assays

et al. 2021

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“…Polydatin and pterostilbene are natural precursors of resveratrol that have been demonstrated having stronger antioxidant and anti-inflammatory effects, and most importantly, a better bioavailability compared to resveratrol [ 13 ]. Their protective effects on COVID-19, especially those from polydatin, have recently raised great interest [ 14 ]. Ellagic acid, manly derived from pomegranate ( Punica granatum L.) fruits, has already demonstrated an attenuating interaction between SARS-CoV-2 Spike glycoprotein and the human angiotensin-converting enzyme 2 (ACE2) receptor, which is the key event of virus infection [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Combined Polyphenols and Micronutrients against Influenza A Virus and SARS-CoV-2 Infection In Vitro

et al. 2021

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Polyphenols have been widely studied for their antiviral effect against respiratory virus infections. Among these, resveratrol (RV) has been demonstrated to inhibit influenza virus replication and more recently, it has been tested together with pterostilbene against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the present work, we evaluated the antiviral activity of polydatin, an RV precursor, and a mixture of polyphenols and other micronutrients, named A5+, against influenza virus and SARS-CoV-2 infections. To this end, we infected Vero E6 cells and analyzed the replication of both respiratory viruses in terms of viral proteins synthesis and viral titration. We demonstrated that A5+ showed a higher efficacy in inhibiting both influenza virus and SARS-CoV-2 infections compared to polydatin treatment alone. Indeed, post infection treatment significantly decreased viral proteins expression and viral release, probably by interfering with any step of virus replicative cycle. Intriguingly, A5+ treatment strongly reduced IL-6 cytokine production in influenza virus-infected cells, suggesting its potential anti-inflammatory properties during the infection. Overall, these results demonstrate the synergic and innovative antiviral efficacy of A5+ mixture, although further studies are needed to clarify the mechanisms underlying its inhibitory effect.

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“…Although there are research interests on the potential therapeutic effects of quercetin in COVID-19 patients, there is a dearth of information on clinical benefits associated with the supplementation of quercetin in COVID-19 patients ( Aucoin et al., 2020 ; Colunga Biancatelli et al., 2020 ). Also, resveratrol and polydatin which is the bioavailable form have received attention with respect to COVID-19 therapy due to previously reported antioxidant and anti-inflammatory effects in in vitro and in vivo models of diseases for which oxidative stress and inflammation are implicated ( Bonucci et al., 2020 ; Lo Muzio et al., 2020 ). However, in-depth studies are required to establish these suggestions.…”

Section: Therapeutic Potential Of Antioxidants In Covid-19 Treatmentmentioning

confidence: 99%

Metabolic Implications of Oxidative Stress and Inflammatory Process in SARS-CoV-2 Pathogenesis: Therapeutic Potential of Natural Antioxidants

Forcados

Muhammad

Oladipo

et al. 2021

Front. Cell. Infect. Microbiol.

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COVID-19 is a zoonotic disease with devastating economic and public health impacts globally. Being a novel disease, current research is focused on a clearer understanding of the mechanisms involved in its pathogenesis and viable therapeutic strategies. Oxidative stress and inflammation are intertwined processes that play roles in disease progression and response to therapy via interference with multiple signaling pathways. The redox status of a host cell is an important factor in viral entry due to the unique conditions required for the conformational changes that ensure the binding and entry of a virus into the host cell. Upon entry into the airways, viral replication occurs and the innate immune system responds by activating macrophage and dendritic cells which contribute to inflammation. This review examines available literature and proposes mechanisms by which oxidative stress and inflammation could contribute to COVID-19 pathogenesis. Further, certain antioxidants currently undergoing some form of trial in COVID-19 patients and the corresponding required research gaps are highlighted to show how targeting oxidative stress and inflammation could ameliorate COVID-19 severity.

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Polydatin and its potential protective effect on COVID-19

Cited by 9 publications

References 7 publications

Interference of Polydatin/Resveratrol in the ACE2:Spike Recognition during COVID-19 Infection. A Focus on Their Potential Mechanism of Action through Computational and Biochemical Assays

Interference of Polydatin/Resveratrol in the ACE2:Spike Recognition during COVID-19 Infection. A Focus on Their Potential Mechanism of Action through Computational and Biochemical Assays

Protective Role of Combined Polyphenols and Micronutrients against Influenza A Virus and SARS-CoV-2 Infection In Vitro

Metabolic Implications of Oxidative Stress and Inflammatory Process in SARS-CoV-2 Pathogenesis: Therapeutic Potential of Natural Antioxidants

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