Polycythemia following renal transplantation unrelated to the allograft

Varkarakis, M. J.; Sampson, D; Gerbasi, Joseph R.; Bender, Merrill A.; Mirand, E. A.; Murphy, Gerald P.

doi:10.1002/jso.2930030209

Cited by 16 publications

(1 citation statement)

References 12 publications

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“…Recently, some authors, finding erythrocytosis more frequently in transplanted patients with native kidneys in place, suggest the kidneys may cause an increased erythropoietin (Ep) production by a mechanism that is presently unknown (5,6). Erythrocytosis was observed also in patients in whom bilateral nephrectomy was performed before renal transplantation, showing that the original kidneys cannot be considered the most likely source of Ep (7).…”

Section: Erythroid Progenitor Growth In Erythrocytosic Transplanted Pmentioning

confidence: 99%

Erythroid Progenitor Growth in Erythrocytosic Transplanted Patients

Lamperi

Carozzi

1985

Artificial Organs

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In 55 patients who underwent renal transplantation, erythrocytosis (E) was observed in 6. In all patients, the growth of erythroid progenitors [burst-forming unit erythroid (BFU-e)], using mononuclear blood cells, was evaluated in in vitro cultures. The results showed a significant increase of serum erythropoietin (s-Ep) in erythrocytosis and in nonerythrocytosis patients with a subsequent decrease when hematocrit (Hct) and hemoglobin (Hb) reached high levels, showing a recovery of a feedback control system. Notwithstanding the diminution of s-Ep, six patients demonstrated further progressive rise of the Hct and Hb to a final state of E. The in vitro BFU-e cultures from these patients showed a noticeable sensitivity to progressively reduced doses of Ep and also the capacity to develop a few colonies when the medium was Ep-free. These results were not verified using peripheral blood depleted of monocyte and/or T lymphocyte cells. Therefore, in transplanted patients with erythrocytosis, it is possible that particular cellular interactions stimulate an early hyperproliferation of BFU-e with a greater Ep sensitivity and at least partly the capacity to grow also in the absence of Ep.

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Section: Erythroid Progenitor Growth In Erythrocytosic Transplanted Pmentioning

confidence: 99%