Polycystic ovary syndrome (PCOS) and adolescence: How can we manage it?

Capozzi, Anna; Scambia, Giovanni; Lello, Stefano

doi:10.1016/j.ejogrb.2020.04.024

Cited by 9 publications

(7 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Obesity synergistically with PCOS increases IR and hyperinsulinaemia [ 20 , 21 ] and affects worse metabolic prognosis [ 21 , 22 ]. The development of glucose abnormalities is a multifactorial process that can develop in PCOS subjects from adolescence [ 23 ] and may be exacerbated by ageing [ 24 ]. It has been found that even non-obese and young women with PCOS have a higher risk of prediabetes (preDM), diabetes mellitus type 2 (T2DM) and gestational diabetes mellitus compared to age- and weight-matched women without PCOS [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in Metabolic Profile in the Women with a History of PCOS—A Long-Term Follow-Up Study

Jacewicz-Święcka

Kowalska

2020

JCM

View full text Add to dashboard Cite

Data concerning metabolic consequences in women with polycystic ovary syndrome (PCOS) are delivered mainly by cross-sectional studies. In this research, we re-examined 31 Caucasian PCOS women after a median period of 120.9 months to evaluate the changes in metabolic syndrome components. Clinical examination, oral glucose tolerance test with estimations of glucose and insulin, lipids, sex hormone-binding globulin (SHBG) and sex hormones assessments were performed on two occasions. Additionally, the euglycaemic hyperinsulinaemic clamp technique was used at the baseline to assess insulin sensitivity (M-clamp value). In the end, the median age of participants was 35. We observed an increase in glucose concentrations, a decrease in insulin concentrations and no changes in insulin resistance markers. Final mean glucose, mean insulin, Matsuda index and body mass index (BMI) were correlated with baseline M-clamp value and SHBG (p < 0.01). During the follow-up, no one in the sample developed diabetes. The annualised incidence rate for conversion from normoglycaemia to prediabetes totalled 4.5%. Baseline BMI, free androgen index, fasting glucose and M-clamp value were identified as prediabetes predictors in young PCOS women (respectively, OR = 1.17, OR = 1.42, OR = 1.2, OR = 0.73, p < 0.05). Prediabetes appeared in 76.47% of the women with a final BMI of ≥ 25 kg/m2 and in 7.14% of the normal-weight women (p = 0.0001). In conclusion, we report a high rate of adverse change in glucose metabolism in overweight and obese participants, a deterioration in β-cell function and strong correlations between metabolic parameters assessed in the third and the fourth decade in PCOS women, emphasising the role of early intervention to prevent cardiometabolic diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

Changes in Metabolic Profile in the Women with a History of PCOS—A Long-Term Follow-Up Study

Jacewicz-Święcka

Kowalska

2020

JCM

View full text Add to dashboard Cite

show abstract

“…Al suprimir la secreción de hormona luteinizante, estos fármacos disminuyen la producción de hormonas androgénicas a nivel de los ovarios. Además, promueven la biosíntesis hepática de globulinas transportadoras de hormonas sexuales, disminuyendo así los niveles séricos de andrógenos (22). El inconveniente que se presenta con los ACOS es que se sabe que afectan el metabolismo de carbohidratos: pueden agravar la insulino-resistencia y presidir una mayor producción hepática de triglicéridos (23).…”

Section: Anticonceptivos Orales Combinadosunclassified

Farmacoterapia y nuevos tratamientos alternativos para el Síndrome de Ovario Poliquístico.

Arias

Zúñiga

Camacho

et al. 2022

View full text Add to dashboard Cite

El Síndrome de ovario poliquístico (SOP) es el desorden endocrinológico más frecuente en mujeres en edad reproductiva y es la causa más importante de infertilidad por anovulación crónica. Al ser una patología de origen multifactorial su abordaje no se encuentra bien definido, por lo que esta revisión tiene como fin explicar los tratamientos disponibles a nivel mundial. La primera línea de tratamiento históricamente utilizada es la modificación del estilo de vida. Los anticonceptivos orales combinados (ACOS) son la primera elección como tratamiento farmacológico y son utilizados para manejo a largo plazo de la patología. Los sensibilizadores de insulina son una alternativa útil en el manejo de la resistencia a la insulina y constituyen una opción idónea para agregar secundariamente a cualquier tratamiento de primera línea. Creciente evidencia científica provee a los prescriptores con nuevas herramientas alternativas como suplementos, nuevos fármacos, probióticos e intervenciones quirúrgicas para abordar multifactorialmente esta afección. Finalmente, se concluye que las terapias discutidas pueden ser utilizadas solas o en conjunto y se resalta la importancia de individualizar el abordaje de cada paciente con las alternativas disponibles más adecuadas.

show abstract

“…As defined by the World Health Organisation, adolescence is the period between 10 and 19 years of age that includes significant and critical changes in growth, development, and puberty due to the overlap of normal pubertal physiological changes such as irregular menstrual cycles, acne, and polycystic ovarian morphology on pelvic ultrasound with the PCOS diagnostic criteria [4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hormonal Profile and Ovarian Morphology among Adolescent Girls with Menstrual Irregularities in a Tertiary Care Centre at Central India

Patel

Pushpalatha

Singh

et al. 2022

The Scientific World Journal

View full text Add to dashboard Cite

Menstrual disturbances are common among adolescents with a prevalence rate of 11.3–26.7%. The most frequent menstrual irregularities are oligomenorrhea, menorrhagia, polymenorrhoea, and hypomenorrhea. PCOS (polycystic ovarian syndrome) is now recognized as the most prevalent endocrine disorder among the women of reproductive age. The current study was planned to evaluate socio-demographic factors, endocrine profiles, and ovarian morphology among adolescent girls with menstrual irregularities and compare these parameters in different phenotypes of adolescent PCOS cases. It is a hospital-based cross-sectional study among 248 adolescent girls (10–19 years) with menstrual irregularities. After obtaining informed consent, history and clinical examination findings were recorded on preform proforma. All girls were assessed on day 2/3 of the menstrual cycle for hormonal profile (serum TSH, FSH, LH, prolactin, and serum testosterone) and ovarian morphology (by transabdominal ultrasonography). All participating girls were divided into three groups (groups 1, 2, and 3) corresponding to phenotypes A, B, & D as per the Rotterdam criteria. In the study, oligomenorrhea was the most common menstrual disorder (70.97%). Biochemical hyperandrogenism and thyroid dysfunction were reported in 14.91% and 8.46% of girls, respectively. Our study noted that phenotype D ,i.e., group 3 (MI + PCOM-HA; 49.43%) was the most common phenotype in the study. In a comparative analysis of different groups, significant differences ( p < 0.05 ) in hormonal and metabolic parameters showed highest in group 2, which represents phenotype B of PCOS (hyperandrogenic anovulation). This analysis revealed that adolescent hyperandrogenism (phenotypes A and B) is associated with a more deranged hormonal and metabolic profile than nonandrogenic PCOS (phenotype D). To prevent long-term sequelae, lifestyle changes, early treatment, and close follow-up are recommended in this subset of girls.

show abstract

Polycystic ovary syndrome (PCOS) and adolescence: How can we manage it?

Cited by 9 publications

References 42 publications

Changes in Metabolic Profile in the Women with a History of PCOS—A Long-Term Follow-Up Study

Changes in Metabolic Profile in the Women with a History of PCOS—A Long-Term Follow-Up Study

Farmacoterapia y nuevos tratamientos alternativos para el Síndrome de Ovario Poliquístico.

Evaluation of Hormonal Profile and Ovarian Morphology among Adolescent Girls with Menstrual Irregularities in a Tertiary Care Centre at Central India

Contact Info

Product

Resources

About