Polycystic Ovary Syndrome is Associated with Elevated Periostin Levels

Abstract

Purpose Periostin is a secreted extracellular matrix protein that is strongly associated with triglyceride metabolism, chronic inflammation, and insulin resistance. Growing evidence suggests that there is a link between periostin and ovarian function. Our aim was to ascertain whether circulating periostin levels are altered in women with polycystic ovary syndrome (PCOS) and to further explore the relationship between periostin and glucose metabolism disorder in PCOS patients. Methods In total, 50 women with PCOS and 30 age-matched controls without PCOS were recruited for this cross-sectional study. Periostin levels were measured using ELISA as well. Results Circulating periostin levels were significantly elevated in PCOS women compared with controls [4206.75(222.00, 4815.25) vs. 430.75(142. 13, 730.86) ng/ml, P=0. 005]. Spearman’s correlation analysis showed that serum periostin levels had a positive correlation with body mass index (BMI), uric acid, homeostasis model assessment of insulin resistance (HOMA-IR), high-sensitive C reactive protein (hs-CRP), and a negative correlation with insulin sensitivity index (ISI). Logistic regression models revealed that PCOS was correlated with waist to hip ratio (WHR), fasting blood glucose (FBG), and periostin levels. In addition, multivariate linear regression analyses showed that FBG, HOMA-IR, and the lipid accumulation index (LAP) were independent factors influencing serum periostin levels. Conclusion PCOS is associated with elevated levels of periostin.

Serum Periostin as a Potential Biomarker in Pediatric Patients with Primary Hypertension

“…There is conflicting data concerning the role of periostin in lipid metabolism. By contrast with our results, in two Chinese studies involving young women with polycystic ovary syndrome [ 29 ] and adult obese patients with type 2 diabetes [ 33 ], periostin concentration was directly correlated with BMI and triglycerides and inversely correlated with HDL-cholesterol. Lu et al found that overexpression of periostin in obese rats resulted in liver steatosis and hypertriglyceridemia via activation of c-Jun N-terminal kinase (JNK) signaling pathway and downregulation of peroxisome proliferator-activated receptor alpha (PPARα) [ 60 ].…”

“…Our multivariate analysis revealed a positive correlation between uric acid and periostin levels. A similar positive relation was found in Chinese adult women with polycystic ovary syndrome [ 29 ]. It is possible that periostin is released in response to subclinical damage caused by uric acid elevation.…”

“…Sample size was estimated based on available literature on periostin with statistical power 0.8, p = 0.05, and effect size 0.55 should be ~50 [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. Fifty pediatric patients with PH were recruited to this single-center cross-sectional study from patients hospitalized in a pediatric nephrology center between February 2018 and March 2019.…”

Periostin Contributes to Immunoglobulin a Nephropathy by Promoting the Proliferation of Mesangial Cells: A Weighted Gene Correlation Network Analysis

“…Additionally, POSTN knockdown attenuated 5/6 nephrectomy-induced intrarenal activation of the renin-angiotensin system, fibrosis, and inflammation in rats, implying a role in the development of CKD (Bian et al, 2019a). In a risk prediction model of ovarian cancer, POSTN combined with two other markers had high prognostic accuracy (Riester et al, 2014), and another study found that polycystic ovary syndrome is associated with elevated POSTN levels (Chen et al, 2019). Although POSTN levels in human urine may have prognostic value in IgAN, this has not been confirmed (Hwang et al, 2016).…”

Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells

“…The role of the extracellular matrix in the development of cancer has also been demonstrated, including those associated with epithelial cells in the ovary [ 7 ]. The role of the ECM has also been described in the pathogenesis of other diseases related to the reproductive system, including PCOS (polycystic ovary syndrome) [ 8 , 9 , 10 ] and POI (premature ovarian insufficiency) [ 11 , 12 ]. The extensively described involvement of extracellular matrix components in signaling pathways within the ovary highlights the role of the ECM in folliculogenesis [ 13 ] and in pathological processes [ 14 ] which altogether may provide valuable therapeutic insights.…”