Polycystic ovary syndrome is an independent risk factor for hypertensive disorders of pregnancy: A systematic review, meta-analysis, and meta-regression

Pan, Haixia; Xian, Peiyi; Yang, Daopeng; Zhang, Chunren; Tang, Hua; He, Xiaoying; Lin, Han; Ma, Hongxia; Lai, Ming-Kuen

doi:10.1007/s12020-021-02886-9

Cited by 16 publications

(15 citation statements)

References 53 publications

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“…Risk factors for gestational hypertension and preeclampsia were largely similar; aRRs for gestational hypertension and preeclampsia for overweight were 1.80 (95% CI, 1.35–2.41) and 1.93 (95% CI, 1.37–2.70), respectively; for obesity, 2.81 (95% CI, 2.07–3.81) and 3.38 (95% CI, 2.40–4.76); for nulliparity, 2.59 (95% CI, 1.90–3.52) and 2.78 (95% CI, 2.00–3.86); for preeclampsia in previous pregnancy, 14.09 (95% CI, 9.28–21.40) and 6.35 (95% CI, 3.69–10.94); for diabetes, 3.24 (95% CI, 1.17–8.97) and 3.76 (95% CI, 1.62–8.71); and for twin birth, 4.82 (95% CI, 1.47–15.83) and 10.25 (95% CI, 5.48–19.15). 19…”

Section: Adverse Pregnancy Outcomesmentioning

confidence: 99%

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2023

Circulation

2,711

702

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BACKGROUND: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). METHODS: The American Heart Association, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing. The 2023 Statistical Update is the product of a full year’s worth of effort in 2022 by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. The American Heart Association strives to further understand and help heal health problems inflicted by structural racism, a public health crisis that can significantly damage physical and mental health and perpetuate disparities in access to health care, education, income, housing, and several other factors vital to healthy lives. This year’s edition includes additional COVID-19 (coronavirus disease 2019) publications, as well as data on the monitoring and benefits of cardiovascular health in the population, with an enhanced focus on health equity across several key domains. RESULTS: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. CONCLUSIONS: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

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Section: Adverse Pregnancy Outcomesmentioning

confidence: 99%

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2023

Circulation

2,711

702

View full text Add to dashboard Cite

show abstract

“…However, when comparing the hyperandrogenic subgroup to the background population, they had a significantly increased risk of preeclampsia during pregnancy, implying that hyperandrogenemia was possibly a better predictor for hypertension in pregnant women with PCOS. On the other hand, a meta-analysis published in 2021 [ 65 ] including 30 studies found that PCOS was associated with a higher risk of hypertensive disorders of pregnancy (OR 2.02) including pregnancy-induced hypertension (OR 1.94) and preeclampsia PE (OR 2.07), with the association remaining high after adjusting for body mass index (BMI) and the increased risk of hypertensive disorders of pregnancy for the PCOS group remaining significant in subgroups of BMI.…”

Section: Hypertension In Pregnancy (Preeclampsia)mentioning

confidence: 99%

Polycystic Ovarian Syndrome (PCOS): Does the Challenge End at Conception?

Mirza

Tahlak

Rjeili

et al. 2022

IJERPH

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Polycystic ovary syndrome (PCOS) is a prevalent condition that not only has the potential to impede conception but also represents the most common endocrine dysfunction in fertile women. It is considered a heterogeneous and multifaceted disorder, with multiple reproductive and metabolic phenotypes which differently affect the early- and long-term syndrome’s risks. Undoubtedly, the impact of PCOS on infertility has attracted most of the attention of healthcare providers and investigators. However, there is growing evidence that even after conception is achieved, PCOS predisposes the parturient to several adverse pregnancy outcomes including a high risk of pregnancy-induced hypertension, spontaneous abortion, gestational diabetes, preeclampsia, and preterm birth, which increase the risks of stillbirth and neonatal death. Fetal growth abnormalities may also be more common, but the relationship is less well defined. This narrative review aims to summarize current knowledge regarding these conditions as they interplay with PCOS and concludes that although there appears to be an increase in these complications during the pregnancy of women with PCOS, there is a need for further research to clarify the possible confounding impact of obesity. Implications for clinical practice and future research are outlined.

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“…Pan et al [28] conducted a meta-analysis of 30 observational studies to evaluate the risk of HDP in individuals with PCOS compared with those without PCOS. PCOS, HDP, and GDM were identified by MESH terms, so criteria used for diagnosis likely varied among the studies.…”

Section: Evidence For An Increased Risk Of Gestational Diabetes In Po...mentioning

confidence: 99%

Gestational diabetes and other adverse pregnancy outcomes in polycystic ovary syndrome

Selen

Powe

2022

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of reviewThis review provides an update on gestational diabetes (GDM) and other adverse pregnancy outcomes in individuals with polycystic ovary syndrome (PCOS), one of the most common metabolic disorders and causes of infertility. Recent findingsRecent studies using Rotterdam diagnostic criteria for PCOS have supported prior literature suggesting that pregnant individuals with PCOS are at an increased risk of GDM. Risk factors for GDM in this population include overweight/obesity, insulin resistance, hyperandrogenism, amenorrhea, and history of miscarriage. It is possible that subtypes of PCOS (metabolic vs. lean/reproductive) pose differential risk. There are no current screening or treatment guidelines specifically for individuals with PCOS for GDM prevention. Although metformin has been studied for GDM prevention in PCOS, there has been no proven benefit. For infertility treatment, assisted reproductive technology and in-vitro fertilization do not appear to increase the risk of GDM in individuals with PCOS desiring pregnancy.

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Polycystic ovary syndrome is an independent risk factor for hypertensive disorders of pregnancy: A systematic review, meta-analysis, and meta-regression

Cited by 16 publications

References 53 publications

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Polycystic Ovarian Syndrome (PCOS): Does the Challenge End at Conception?

Gestational diabetes and other adverse pregnancy outcomes in polycystic ovary syndrome

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