Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with Obesity: The Role of Nutrition Therapy and Food Supplements as a Strategy to Protect Fertility

Calcaterra, Valeria; Verduci, Elvira; Cena, Hellas; Magenes, Vittoria Carlotta; Todisco, Carolina Federica; Tenuta, Elisavietta; Gregorio, C. A.; Giuseppe, Rachele De; Bosetti, Alessandra; Profio, Elisabetta Di; Zuccotti, Gian Vincenzo

doi:10.3390/nu13061848

Cited by 103 publications

(112 citation statements)

References 229 publications

(329 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It seems that although the determination of the reproductive phenotype of PCOS will concern mainly women of reproductive age who are trying to get pregnant, restoring ovulation (and in a broader perspective -fertility) may be a more important goal in terms of reproductive health than just obtaining regular bleeding and reduce the severity of hyperandrogenisation symptoms at any stage of life. This approach is confirmed in the latest publications on the therapeutic management of girls with PCOS (Calcaterra, Verduci, Cena, Magenes, Todisco, 2021b;Ibáñez et al, 2020). To improve the general health of patients, it is also important to correct metabolic disorders and reduce cardiovascular risk, which is not achieved with the use of hormonal contraception only.…”

Section: Pcos Phenotypes In Adult Women -Basics Of Personalized Therapymentioning

confidence: 86%

“…The authors directly emphasize the negative impact of hormonal contraception on the possibility of ovulation within at least a few months after discontinuation of contraception . Nutritional therapy is also of particular importance in the aspect of fertility protection (Calcaterra et al, 2021b). The implementation of these important recommendations should contribute to the improvement of the reproductive health of adult women with PCOS and metabolic disorders related to this disease, as well as of girls diagnosed with PCOS or at increased risk of PCOS.…”

Section: Discussionmentioning

confidence: 99%

“…More and more attention is paid to dietary supplements with beneficial effects in patients (including teenagers) with obesity and PCOS (inositols, omega-3 fatty acids, berberine, curcumin), using pre-and probiotics and maintaining an optimal gut microbiome. The use of nutritional therapy and dietary supplements in teenagers with PCOS and insulin resistance is treated as a preventive action aimed at restoring ovulation and protecting the fertility of these girls (Calcaterra et al, 2021b).…”

Section: Hyperandrogenism and Pcos-related Metabolic Disorders In Adolescentstherapeutic Optionsmentioning

confidence: 99%

See 2 more Smart Citations

Promotion of reproductive and metabolic health - current trends in the treatment and prevention of polycystic ovary syndrome in different periods of life

Smyczyńska¹

2021

FetR

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is one of the most common hormonal disorders and causes of infertility in women in reproductive age. Diagnostic criteria of PCOS in adult women include: ovulation disorders, hyperandrogenism and polycystic ovaries. According to most recommendations, 2 out of these 3 criteria are confirm the diagnosis of PCOS. In girls during puberty and in the first years after menarche, different diagnostic criteria of menstrual disorders should be taken into account (variable length of menstrual cycles, monophasic cycles) and the limited usefulness of ultrasound examination for PCOS diagnosis within 8 years after menarche. Fairly extensive differential diagnosis is also necessary, especially – exclusion of adrenal hyperandrogenism. Moreover, the diagnostic criteria of PCOS do not take into account the metabolic disorders found in most patients (obesity, insulin resistance, type 2 diabetes), which should be diagnosed as early as possible and treated appropriately. This is especially true for teenagers, in whom the unequivocal diagnosis of PCOS or its exclusion may be very difficult. Current recommendations regard hormonal contraception as the first-line therapy in PCOS, in both adult women and adolescents. Together with its beneficial effect on the reduction of hyperandrogenism and obtaining regular bleeding (which in fact are not menstruations), the unfavorable metabolic effects of hormonal contraception are emphasized, as well as the inadequacy of its use if it is expected to achieve or restore ovulation and fertility. The latest reports indicate the legitimacy of treatment aimed at correcting disorders of carbohydrate metabolism and its greater effectiveness compared to the use of oral contraceptives in both adult women and girls with PCOS. In the pharmacotherapy of insulin resistance, metformin is of fundamental importance, the use of pioglitazone, GLP-1 receptor agonists or inositols is also proposed. Adequate lifestyle and dietary modification are of major importance in the treatment and prevention of PCOS. The mechanisms of "inheritance" of PCOS and insulin resistance with the participation of epigenetic modifications are still better understood, taking into account the effects of exposure to androgen excess in utero, intrauterine growth retardation, and maternal obesity and hyperalimentation. This creates new possibilities for PCOS prophylaxis.

show abstract

Section: Pcos Phenotypes In Adult Women -Basics Of Personalized Therapymentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Hyperandrogenism and Pcos-related Metabolic Disorders In Adolescentstherapeutic Optionsmentioning

confidence: 99%

See 1 more Smart Citation

Promotion of reproductive and metabolic health - current trends in the treatment and prevention of polycystic ovary syndrome in different periods of life

Smyczyńska¹

2021

FetR

View full text Add to dashboard Cite

show abstract

“…An important limitation is the high dropout rate among women with low evidence of a long-term effect, which led to the consideration of VLCDs as safe for short dietary cycles. It could be suitable to shift to a Mediterranean dietary pattern, with physical activity, to achieve results in the long term [ 213 ].…”

Section: Ketogenic Diet and Metabolic Disorders In Adults And Children: State-of-the-artmentioning

confidence: 99%

Metabolic Derangement in Pediatric Patient with Obesity: The Role of Ketogenic Diet as Therapeutic Tool

et al. 2021

Self Cite

View full text Add to dashboard Cite

Obesity is defined as a condition characterized by an excessive fat accumulation that has negative health consequences. Pediatric obesity is associated with an increased risk for many diseases, including impaired glycemic and lipidic control that may lead to the development of chronic, and potentially disabling, pathologies, such as type 2 diabetes mellitus (T2DM) and cardiovascular events, in adult life. The therapeutic strategy initially starts with interventions that are aimed at changing lifestyle and eating behavior, to prevent, manage, and potentially reverse metabolic disorders. Recently, the ketogenic diet (KD) has been proposed as a promising dietary intervention for the treatment of metabolic and cardiovascular risk factors related to obesity in adults, and a possible beneficial role has also been proposed in children. KD is very low in carbohydrate, high in fat, and moderate to high in protein that may have the potential to promote weight loss and improve lipidic derangement, glycemic control, and insulin sensitivity. In this review, we present metabolic disorders on glycemic and lipidic control in children and adolescents with obesity and indication of KD in pediatrics, discussing the role of KD as a therapeutic tool for metabolic derangement. The results of this review may suggest the validity of KD and the need to further research its potential to address metabolic risk factors in pediatric obesity.

show abstract

“…The approach of MNT in these patients aims at improving insulin resistance and metabolic and reproductive functions by means of personalized diets. The use of a nutrition therapy may be considered a preventive strategy to safeguard both fertility and preconception health [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Nutripedia: The Fight against the Fake News in Nutrition during Pregnancy and Early Life

et al. 2021

Self Cite

View full text Add to dashboard Cite

(1) Background. Early nutrition and lifestyle before and during pregnancy, breastfeeding, infancy, and early childhood can affect the risk of developing common non-communicable diseases during adulthood such as obesity and metabolic syndrome. To support positive long-term outcomes, it is essential to debunk fake news and provide evidence-based nutritional recommendations. “Nutripedia-Informati per Crescere” is a new tool delivering information and education on appropriate nutrition of mothers and babies during pregnancy and the first years of life. (2) Methods. Nutripedia provides the readers with evidence-based scientific contents in an easy-to-access fashion through a website, a social media page and a personalized advice app called “Nutripedia Chatbot”. (3) Results. Forty articles were published on Nutripedia website with more than 220,000 total views. Social channel activation via bloggers reached over 9 million parents. 14,698 users downloaded Nutripedia chatbot, through which a total of 1930 questions were directed to experts while over 24,000 responses were provided by the app. (4) Conclusions. The use of different communication tools delivering evidence-based nutritional information such as Nutripedia is increasing and could offer supportive strategies to provide scientific information to large audiences and contribute fighting fake news. Future research could investigate the effectiveness of this important health campaign.

show abstract

Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with Obesity: The Role of Nutrition Therapy and Food Supplements as a Strategy to Protect Fertility

Cited by 103 publications

References 229 publications

Promotion of reproductive and metabolic health - current trends in the treatment and prevention of polycystic ovary syndrome in different periods of life

Promotion of reproductive and metabolic health - current trends in the treatment and prevention of polycystic ovary syndrome in different periods of life

Metabolic Derangement in Pediatric Patient with Obesity: The Role of Ketogenic Diet as Therapeutic Tool

Nutripedia: The Fight against the Fake News in Nutrition during Pregnancy and Early Life

Contact Info

Product

Resources

About