Polycystic ovary syndrome in adult women

Ortiz-Flores, A.E.; Luque‐Ramírez, Manuel; Escobar‐Morreale, Héctor F.

doi:10.1016/j.medcle.2019.02.019

Cited by 21 publications

(20 citation statements)

References 30 publications

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“…PCOS has a high incidence in countries around the world. Epidemiological studies [18][19][20]have reported that 30 % of women of childbearing age with abnormal BMI have the occurrence of PCOS. At the same time, the disease is also accompanied by a variety of metabolic-related diseases, which affect the whole body.…”

Section: Discussionmentioning

confidence: 99%

The risk factors of gestational hypertension in patients with polycystic ovary syndrome: a retrospective analysis

Zhou

Ji²,

Wang

2021

BMC Pregnancy Childbirth

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Background The hypertensive disorders complicating pregnancy (HDCP) is common in patients with polycystic ovary syndrome (PCOS), yet the potential influencing factors remained unclear. We aimed to assess the independent risk factors of HDCP in patients with PCOS, to provide clinical evidences for the management of PCOS. Methods Pregnant PCOS patients treated in our hospital from June 1, 2018 to November 30, 2020 were approached. The personal and clinical characteristics of patients with and without gestational hypertension were evaluated. Logistic regressions were conducted to identify the independent risk factors of HDCP, Receiver operating characteristics (ROC)curve analysis was conducted to evaluate the predicting value. Results A total of 188 PCOS patients were included, the incidence of HDCP in patients with PCOS was 27.66 %. There were significant differences in the age, BMI, family history of hypertension, the history of adverse pregnancy, history of contraceptive pills use and family history of HDCP between HDCP group and no-HDCP group (all p < 0.05), and there were no significant differences in the family history of diabetes, multiple pregnancy and long-term smoking history between HDCP group and no-HDCP group (all p > 0.05). Age ≥ 27y(OR2.048, 95 %CI1.121 ~ 3.208), BMI ≥ 24 kg/m2(OR1.463, 95 %CI1.069 ~ 2.011), family history of hypertension(OR2.129, 95 %CI1.093 ~ 3.042), the history of adverse pregnancy(OR2.435, 95 %CI1.264 ~ 4.085), history of contraceptive pills use(OR3.806, 95 %CI1.184 ~ 6.102), family history of HDCP(OR1.934, 95 %CI1.016 ~ 2.774) were the independent risk factors of HDCP in patients with PCOS (all p < 0.05). ROC curve analyses indicated that those factors had good predictive value on HDCP in PCOS patients. Conclusions The incidence of HDCP in PCOS patients is relatively high. In clinical practice, medical workers should carry out early prevention and intervention measures for these risk factors to reduce the incidence of HDCP.

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Section: Discussionmentioning

confidence: 99%

The risk factors of gestational hypertension in patients with polycystic ovary syndrome: a retrospective analysis

Zhou

Ji²,

Wang

2021

BMC Pregnancy Childbirth

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“…In the first group, polycystic ovarian syndrome is by far the leading cause, followed by nonclassic congenital adrenal hyperplasia in a small proportion of women. [ 7 ] In the second group, a new-onset state of androgen excess is rare, and it must be ruled out, an androgen-secreating tumor (ovarian or adrenal) as the main cause, followed by ovarian hyperthecosis. [ 8 ] Ovarian tumors associated with androgen secretion mainly originate from the sex cord stroma and include Leydig tumor and stromal luteoma.…”

Section: Discussionmentioning

confidence: 99%

Female androgenetic alopecia with male pattern caused by an androgen-producing tumor

Dueñas

Dueñas²,

Sánchez³

et al. 2020

Int J Trichol

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Female androgenetic alopecia (FAGA) is a common cause of hair loss in women. Typically, it is characterized by a reduction of hair density on biparietal and vertex regions of the scalp with preservation of the anterior hair implantation line. However, it can also appear with recession of the anterior hairline known as FAGA with male pattern (FAGA-M). In these cases, it is important to consider a state of hyperandrogenism and look for other signs such as hirsutism, acne, and menstrual irregularities. A sudden onset in a postmenopausal woman must make us suspicious of an androgen-secreting tumor. We present two cases of FAGA-M secondary to an ovarian tumor that was successfully resolved after surgical treatment.

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“…Todos los ovarios en condiciones normales producen en poca cantidad andrógenos y testosterona. El SOP se caracteriza cuando los niveles de la hormona LH o los niveles de insulina ayudan a producir un exceso de testosterona (8) .…”

Section: Resistencia a La Insulinaunclassified

“…La testosterona y DHT influyen en las alteraciones en el pelo y en su ciclo. Convierten el vello corporal más espeso y oscuro en zonas en donde actúan los andrógenos como cara, cuello, tórax y pubis (8) .…”

Section: Testosteronaunclassified

Síndrome de ovario poliquístico

García-Santamaría

Rodríguez

2021

Rev.exp.med.

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El síndrome de ovario poliquístico (SOP) es la disfunción endocrino-metabólica más frecuente en la mujer, aparece generalmente después de la menarquia, se considera la principal causa de hiperandrogenismo (HA), los genes CYP19, CYP11a, CYP17, CYP21 y FST son susceptibles y han sido identificados como contribuyentes a esta enfermedad. Genera un desequilibrio hormonal de producción atípica de esteroides, estrógenos y andrógenos, impidiendo la ovulación con un crecimiento anormal de folículos, es causante de alteraciones en el ciclo menstrual, promueve la formación de quistes en los ovarios y el aumento de tamaño de estos, acné, hirsutismo, escaso desarrollo mamario, obesidad, infertilidad y cambios emocionales. Para el diagnóstico debe existir la presencia de 2 o 3 de los siguientes condicionantes: oligoanovulación crónica, polisquistosis ovárica por ecografía, hiperandrogenismo clínico o bioquímico; En cuanto al tratamiento, se recomienda utilizar anticonceptivos orales, citrato de clomifeno y metformina.

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Polycystic ovary syndrome in adult women

Cited by 21 publications

References 30 publications

The risk factors of gestational hypertension in patients with polycystic ovary syndrome: a retrospective analysis

The risk factors of gestational hypertension in patients with polycystic ovary syndrome: a retrospective analysis

Female androgenetic alopecia with male pattern caused by an androgen-producing tumor

Síndrome de ovario poliquístico

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