Polycystic ovary syndrome and the risk of endometrial, ovarian and breast cancer: An updated meta-analysis

Li, Zhen; Wang, Yuhua; Wang, Lin-Lin; Hu, Dingtao; Teng, Ying; Zhang, Tingyu; Yan, Zi-Ye; Wang, Fang; Zou, Yanfeng

doi:10.1177/00369330221107099

Cited by 12 publications

(12 citation statements)

References 42 publications

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“…Concerning an association between PCOS and ovarian cancer, most previous studies observed no convincing associations 18‐21,23‐25,27‐29 while two studies have reported an increased risk 22,26 . In a USA case‐control study including 476 cases and 4081 controls aged 20‐54 years, Schildkraut et al 26 found a more than 2‐fold increased risk of ovarian cancer (OR 2.52 95% CI 1.08‐5.89) among women with PCOS compared with women without PCOS.…”

Section: Discussionmentioning

confidence: 98%

“…In fact, only the Swedish cohort study by Yin et al 22 had sufficiently long follow‐up to report associations for postmenopausal women, but contrary to our finding, the authors observed an increased risk for premenopausal women, but not for postmenopausal women with PCOS (HR 2.55 95% CI 1.45‐4.50 and HR 1.34 95% CI 0.43‐4.15, respectively). The meta‐analysis by Li et al 27 also showed an increased risk among premenopausal women with PCOS but did not report estimates for postmenopausal women with PCOS. Our finding of an increased risk among postmenopausal women only, which is in discrepancy with earlier studies, is not easily explainable.…”

Section: Discussionmentioning

confidence: 98%

“…15 A further increase in PCOS incidence is expected due to an increasing incidence of obesity worldwide during the last decades. 16,17 To date, a limited number of studies have assessed the association between PCOS and ovarian cancer including five cohort studies, [18][19][20][21][22] four case-control studies, [23][24][25][26] two meta-analyses 27,28 and one pooled analyses of case-control studies. 29 Most studies reported null results, [18][19][20][21][23][24][25]28,29 two studies reported an increased risk 22,26 and the most recent meta-analysis reported null associations overall but increased risk of ovarian cancer in subgroup analysis including high quality studies only, cohort studies only, younger women only and studies that were not adjusted for BMI.…”

Section: Introductionmentioning

confidence: 99%

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Risk of epithelial ovarian tumors among women with polycystic ovary syndrome: A nationwide population‐based cohort study

Frandsen

Svendsen

Nøhr

et al. 2023

Intl Journal of Cancer

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An association between polycystic ovary syndrome (PCOS) and epithelial ovarian tumors is biologically plausible as conditions inherent to PCOS such as excessive androgenic hormones, reproductive factors and obesity are also risk factors for these hormone-sensitive tumors. However, previous studies have showed conflicting results and have various methodological limitations. This population-based cohort study investigates the association between PCOS and epithelial ovarian tumors and includes all women born in Denmark between January 1, 1940 and December 31, 1993 (n = 1 719 304). PCOS diagnoses, ovarian cancer and borderline ovarian tumor diagnoses, covariates, migration and vital status were obtained from the Danish national registers. Adjusted cox proportional hazard regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CI) for epithelial ovarian cancer and for borderline ovarian tumors overall as well as for histological subtypes separately. During median 26 years of follow-up we identified 6490 women with ovarian cancer and 2990 women with borderline ovarian tumors. Overall, we observed no marked associations between a diagnosis of PCOS and overall epithelial ovarian cancer or overall epithelial borderline ovarian tumors, irrespective of time since diagnosis. However, we found an increased risk of ovarian cancer among postmenopausal women with PCOS (HR 2.28 95% CI 1.02-5.09) and an increased risk of serous borderline ovarian tumors (HR 2.34 95% CI 1.21-4.53) in women with PCOS compared with women without PCOS. Importantly, low statistical precision is a crucial limitation of our study and in previous studies and larger studies with longer follow-up are therefore warranted.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Risk of epithelial ovarian tumors among women with polycystic ovary syndrome: A nationwide population‐based cohort study

Frandsen

Svendsen

Nøhr

et al. 2023

Intl Journal of Cancer

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“…Obesity appears to have a causal role in polycystic ovary syndrome (PCOS). 51 In addition, PCOS is associated with an increased risk of endometrial cancer, that is independent of BMI in age-matched controls 52,53 Some of the contraceptive methods, particularly the COC, may be of benefit in this population, where weight-related eligibility is not contraindicated by local guidelines. However, obesity is more prevalent among women with PCOS presenting to hospital clinics for treatment, and there may be advantages associated with some methods as discussed later.…”

Section: Noncontraceptive Benefits Of Contraceptionmentioning

confidence: 99%

Best Practice Contraception Care for Women with Obesity: A Review of Current Evidence

McNamee

Edelman

et al. 2022

Semin Reprod Med

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The prevalence of obesity among females of reproductive age is increasing globally. Access to the complete range of appropriate contraceptive options is essential for upholding the reproductive rights of this population group. People with obesity can experience stigma and discrimination when seeking healthcare, and despite limited evidence for provider bias in the context of contraception, awareness for its potential at an individual provider and health systems level is essential. While use of some hormonal contraceptives may be restricted due to increased health risks in people with obesity, some methods provide noncontraceptive benefits including a reduced risk of endometrial cancer and a reduction in heavy menstrual bleeding which are more prevalent among individuals with obesity. In addition to examining systems-based approaches which facilitate the provision of inclusive contraceptive care, including long-acting reversible contraceptives which require procedural considerations, this article reviews current evidence on method-specific advantages and disadvantages for people with obesity to guide practice and policy.

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“…Snowden et al 5 provide an assessment of knowledge amongst orthopaedic surgeons about radiation safety. Li et al 6 in a meta-analysis describe an interesting association of polycystic ovarian syndrome with various cancers. Finally, Yitgin et al 7 share their knowledge about optimal duration of surgical procedure for renal stones.…”

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confidence: 99%

Surgical procedure time and postoperative complications: Quality assurance of intraoperative events

Nabi

2022

Scott Med J

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Welcome to September 2022 issue of Scottish Medical Journal. The issue highlights advancements in medical education and research-a basic ambitions of journal since its inception more than 100 years back. Hassan et al. 1 bring in new knowledge on methods of teaching in neuroanatomy. Khatkar and colleagues 2 discuss virtual reality simulation questionnaire survey and reminds us importance of snap-shot assessment. Domenic G et al. 3 report relationship of body composition and BMI with colorectal cancer. In another common cancer in young men, Alifrangis et al. 4 provide a glimpse of current practise perspective of testicular cancer (Seminoma). Clinicians are exposed to risk of radiation injuries and in particularly those working in orthopaedics surgery. Snowden et al. 5 provide an assessment of knowledge amongst orthopaedic surgeons about radiation safety. Li et al. 6 in a meta-analysis describe an interesting association of polycystic ovarian syndrome with various cancers. Finally, Yitgin et al. 7 share their knowledge about optimal duration of surgical procedure for renal stones. They report a lower postoperative complications rate following retrograde intrarenal surgery in patients where procedural time is more than 60 min. There are several implications of these findings: First, it will improve delivery of information to urological surgeons so that careful planning is considered in reducing complications; second, it will help in better patient counselling and may be discuss alternate therapeutic approaches. Collins TC et al. 8 in a previous study reported intraoperative blood transfusion, operative time, return to the operating room, and the number of complications as strong predictors of length of stay in hospital for patients following surgery. These events are inter-related and hence quality assurance of intra-operative events should be focus of quality assurance in the future.I trust the issue will be an enjoyable reading and generate discussion amongst colleagues and the future generations.

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Polycystic ovary syndrome and the risk of endometrial, ovarian and breast cancer: An updated meta-analysis

Cited by 12 publications

References 42 publications

Risk of epithelial ovarian tumors among women with polycystic ovary syndrome: A nationwide population‐based cohort study

Risk of epithelial ovarian tumors among women with polycystic ovary syndrome: A nationwide population‐based cohort study

Best Practice Contraception Care for Women with Obesity: A Review of Current Evidence

Surgical procedure time and postoperative complications: Quality assurance of intraoperative events

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