Polycystic ovary syndrome and postpartum depression among Hispanics and non-Hispanics: a population-based study

Fugal, Adriele; Stanford, Joseph B.; Johnstone, Erica; Kah, Kebba; Schliep, Karen C.

doi:10.1016/j.xagr.2022.100070

Cited by 2 publications

(4 citation statements)

References 35 publications

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Section: Resultsmentioning

confidence: 99%

“…Six studies, all of high quality (Supplemental Table 6), were included examining the association between postpartum depression and PCOS (30)(31)(32)(33)(34)(35)(36). Compared to age-matched women without PCOS, those with PCOS had a higher prevalence of postpartum depression in the meta-analysis, however this association did not reach statistical significance (random effects PR: 1.20; 95% CI: 0.96, 1.50; Fig.…”

Section: Excess Prevalence Of Postpartum Depression In Women With Pcosmentioning

confidence: 99%

See 1 more Smart Citation

Direct Economic Burden of Mental Health Disorders Associated with Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Yadav

Delau

Bonner

et al. 2023

Preprint

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BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common hormone disorder affecting about one in seven reproductive-aged women worldwide and approximately 6 million women in the United States (U.S.). PCOS can be a significant burden to those affected and is associated with an increased prevalence of mental health (MH) disorders such as depression, anxiety, eating disorders, and postpartum depression. We undertook this study to determine the excess economic burden associated with MH disorders in women with PCOS, in order to allow for a more accurate prioritization of the disorder as a public health priority. <br />METHODS: Followed PRISMA reporting guidelines for systematic review, we searched 60 PubMed, Web of Science, EBSCO, Medline, Scopus, and PsycINFO through July 16, 2021, for studies on MH disorders in PCOS. Excluded were studies not in humans, without controls, without original data, or not peer reviewed. As anxiety, depression, eating disorders, and postpartum depression were by far the most common MH disorders assessed by the studies, we performed our meta-analysis on these disorders. Meta-analyses were performed using the DerSimonian-Laird random-effects model to compute pooled estimates of prevalence ratios (PR) for the associations between PCOS and these MH disorders, and then calculated the excess direct costs of related to these disorders in U.S. dollars (USD) for women suffering from PCOS in the U.S. alone. The quality of selected studies was assessed using the Newcastle Ottawa Scale. <br />RESULTS: We screened 78 articles by title/abstract, assessed 43 articles in full-text, and included 25 articles. Pooled PRs were 1.42 (95% CI: 1.32-1.52) for anxiety, 1.65 (95% CI: 1.44- 1.89;) for depression, 1.48 (95% CI: PR: 1.06-2.05) for eating disorders, and 1.20 (95% CI: 0.96-1.50) for postpartum depression, for PCOS relative to controls. In the U.S, the additional direct healthcare costs associated with anxiety, depression and eating disorders in PCOS were estimated to be $1.939 billion/yr., 1.678 billion/yr., and $0.644 billion/yr. in 2021 USD, respectively. Postpartum depression was excluded from the cost analyses due to the non-significant meta-analysis result. Taken together, the additional direct healthcare costs associated with anxiety, depression and eating disorders in PCOS was estimated to be $4.261 billion/yr. in 2021 USD. <br />CONCLUSIONS: Overall, the direct healthcare annual costs for the most common MH disorders in PCOS, namely anxiety, depression, and eating disorders exceeds $4 billion in 2021 USD for the U.S. population alone. Taken together with our prior work, these data suggest that the healthcare-related economic burden of PCOS exceeds $15 billion yearly, considering the costs of PCOS diagnosis, and cost related to PCOS-associated MH, reproductive, vascular, and metabolic disorders. As PCOS has much the same prevalence across the world, the excess economic burden attributable to PCOS globally is enormous, mandating that the scientific and policy community increase its focus on this important disorder. <br />FUNDING: The study was supported, in part, by PCOS Challenge: The National Polycystic Ovary Syndrome Association and by the Foundation for Research and Education Excellence

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Excess Prevalence Of Postpartum Depression In Women With Pcosmentioning

confidence: 99%

Direct Economic Burden of Mental Health Disorders Associated with Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Yadav

Delau

Bonner

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…For example, some studies did not include information on a control group, did not include measures of association, used a continuous outcome instead of dichotomous outcome, or did not provide information about risk/prevalence that was needed to compute the PRs. The general characteristics of the 25 included studies ( Alur-Gupta et al, 2019 ; Tan et al, 2017 ; Karjula et al, 2017 ; Tay et al, 2020 ; Kaur et al, 2019 ; Asik et al, 2015 ; Cesta et al, 2016 ; Hussain et al, 2015 ; Månsson et al, 2008 ; Jedel et al, 2010 ; Li et al, 2017 ; Damone et al, 2019 ; Hollinrake et al, 2007 ; Pastore et al, 2011 ; Cinar et al, 2011 ; Adali et al, 2008 ; Lee et al, 2017 ; Pirotta et al, 2019 ; Koric et al, 2021 ; Joham et al, 2016 ; Muchanga et al, 2017 ; March et al, 2018 ; Tay et al, 2019 ; Alur-Gupta et al, 2021 ; Fugal et al, 2022 ) are detailed in Supplementary file 2a–d .…”

Section: Resultsmentioning

confidence: 99%

“…Six studies, all of high quality ( Supplementary file 2e ), were included examining the association between postpartum depression and PCOS ( Koric et al, 2021 ; Joham et al, 2016 ; Muchanga et al, 2017 ; March et al, 2018 ; Tay et al, 2019 ; Alur-Gupta et al, 2021 ; Fugal et al, 2022 ). Compared to age-matched women without PCOS, those with PCOS had a higher prevalence of postpartum depression in the meta-analysis, however this association did not reach statistical significance (random effects PR: 1.20; 95% CI: 0.96, 1.50; Figure 2D ).…”

Section: Resultsmentioning

confidence: 99%

Direct economic burden of mental health disorders associated with polycystic ovary syndrome: Systematic review and meta-analysis

Yadav

Delau

Bonner

et al. 2023

eLife

View full text Add to dashboard Cite

Background: Polycystic ovary syndrome (PCOS) is the most common hormone disorder affecting about one in seven reproductive-aged women worldwide and approximately 6 million women in the United States (U.S.). PCOS can be a significant burden to those affected and is associated with an increased prevalence of mental health (MH) disorders such as depression, anxiety, eating disorders, and postpartum depression. We undertook this study to determine the excess economic burden associated with MH disorders in women with PCOS in order to allow for a more accurate prioritization of the disorder as a public health priority. Methods: Following PRISMA reporting guidelines for systematic review, we searched PubMed, Web of Science, EBSCO, Medline, Scopus, and PsycINFO through July 16, 2021, for studies on MH disorders in PCOS. Excluded were studies not in humans, without controls, without original data, or not peer reviewed. As anxiety, depression, eating disorders, and postpartum depression were by far the most common MH disorders assessed by the studies, we performed our meta-analysis on these disorders. Meta-analyses were performed using the DerSimonian-Laird random-effects model to compute pooled estimates of prevalence ratios (PR) for the associations between PCOS and these MH disorders and then calculated the excess direct costs related to these disorders in U.S. dollars (USD) for women suffering from PCOS in the U.S. alone. The quality of selected studies was assessed using the Newcastle-Ottawa Scale. Results: We screened 78 articles by title/abstract, assessed 43 articles in full-text, and included 25 articles. Pooled PRs were 1.42 (95% CI: 1.32-1.52) for anxiety, 1.65 (95% CI: 1.44-1.89;) for depression, 1.48 (95% CI: PR: 1.06-2.05) for eating disorders, and 1.20 (95% CI: 0.96-1.50) for postpartum depression, for PCOS relative to controls. In the U.S., the additional direct healthcare costs associated with anxiety, depression, and eating disorders in PCOS were estimated to be $1.939 billion/yr., 1.678 billion/yr., and $0.644 billion/yr. in 2021 USD, respectively. Postpartum depression was excluded from the cost analyses due to the non-significant meta-analysis result. Taken together, the additional direct healthcare costs associated with anxiety, depression, and eating disorders in PCOS were estimated to be $4.261 billion/yr. in 2021 USD. Conclusions: Overall, the direct healthcare annual costs for the most common MH disorders in PCOS, namely anxiety, depression, and eating disorders, exceeds $4 billion in 2021 USD for the U.S. population alone. Taken together with our prior work, these data suggest that the healthcare-related economic burden of PCOS exceeds $15 billion yearly, considering the costs of PCOS diagnosis, and costs related to PCOS-associated MH, reproductive, vascular, and metabolic disorders. As PCOS has much the same prevalence across the world, the excess economic burden attributable to PCOS globally is enormous, mandating that the scientific and policy community increase its focus on this important disorder. Funding: The study was supported, in part, by PCOS Challenge: The National Polycystic Ovary Syndrome Association and by the Foundation for Research and Education Excellence.

show abstract

Polycystic ovary syndrome and postpartum depression among Hispanics and non-Hispanics: a population-based study

Cited by 2 publications

References 35 publications

Direct Economic Burden of Mental Health Disorders Associated with Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Direct Economic Burden of Mental Health Disorders Associated with Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Direct economic burden of mental health disorders associated with polycystic ovary syndrome: Systematic review and meta-analysis

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