Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles

Marquard, Kerri L.; Stephens, Sahar M.; Jungheim, Emily S.; Ratts, Valerie S.; Odem, Randall R.; Lanzendorf, Susan E.; Moley, Kelle H.

doi:10.1016/j.fertnstert.2010.10.026

Cited by 97 publications

(64 citation statements)

References 38 publications

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“…The diameter of human in vivo-matured oocytes ranges from $110 mm to $120 mm (36). In patients with PCOS, in vivo-matured oocytes retrieved from follicles >15 mm after conventional gonadotropin stimulation and hCG priming have a smaller oocyte diameter compared with normo-ovulatory patients (37), which seems to suggest that oocyte diameter may be influenced by differences in the intraovarian milieu. Cavilla et al (21) described an oocyte diameter increase of 3 mm when human oocytes retrieved from follicles of <10 mm in patients with PCO were cultured in vitro for 48 hours, which corresponds to an 8% increase of the initial volume.…”

Section: Discussionmentioning

confidence: 98%

Developmental capacity of in vitro–matured human oocytes retrieved from polycystic ovary syndrome ovaries containing no follicles larger than 6 mm

Guzmán

Ortega-Hrepich

Albuz

et al. 2012

Fertility and Sterility

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Section: Discussionmentioning

confidence: 98%

Developmental capacity of in vitro–matured human oocytes retrieved from polycystic ovary syndrome ovaries containing no follicles larger than 6 mm

Guzmán

Ortega-Hrepich

Albuz

et al. 2012

Fertility and Sterility

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“…The literature contains several studies that report that oocyte maturation is impaired in PCOS (20), oocyte quality and fertilization capacities are reduced (21), and, in addition, obesity contributes to such impaired maturation in PCOS (22)(23)(24). Fedorcsák et al (9) reported that the number of oocytes retrieved was low in PCOS patients.…”

Section: Discussionmentioning

confidence: 99%

Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome

Kalem

Sarı

et al. 2016

J Turkish German Gynecol Assoc

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Results:Variations in cycle variables with BMI and age showed that IVF cycles were negatively affected by increases in obesity and age. Clinical pregnancy rates were found to be lower in the obese group than in the other groups, particularly in the age group above 35 years; however, this difference could not be proven statistically. Conclusion:The present study evaluated obesity and clinical pregnancy rates in IVF cycles in PCOS patients according to age groups, and particularly in the obese group, the clinical pregnancy rates were observed to be lower in the age group ≥35 years than in the other BMI groups; however, this difference was found to be statistically insignificant. (J Turk Ger Gynecol Assoc 2016; 17: 83-90) Keywords: PCOS, body mass index, age, IVF outcome Received: 31 December, 2015 Accepted: 8 March, 2016 Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome Bailey et al. (12) investigated the effect of BMI on the characteristics and outcomes of IVF cycles in PCOS and found lower clinical pregnancy rates in an obese PCOS group than in a lean group and a lower rate of ovarian hyperstimulation syndrome (OHSS) in the obese group. A woman's age is also an important factor in IVF success (13,14). The IVF success rate reduces with increasing age in PCOS, as in all infertile patient groups (15, 16). The literature contains a very limited number of studies that investigate age and BMI together. Heijnen et al. (17) reported that although BMI has a significant and negative effect on female fertility, this effect gradually decreases as women approach their mid-thirties and also in younger women receiving IVF. Above the age of 36 years, on the other hand, the effect of BMI on fertility becomes minimal. PCOS patients were not included in this study. The study by Metwally et al. (8) that investigated 426 IVF/ICSI cycles did not exclude PCOS patients and reported that although obesity does not affect oocyte quality, there is a reduction in embryo quality in patients under the age of 35 years. The hypothesis of the present study assumed that the effect of BMI on the IVF cycles of PCOS patients may vary with age. The present study aimed to investigate age-related variations in the effect of BMI on IVF outcomes. Material and MethodsThis was a cohort study conducted by retrospectively investigating the IVF cycles of 653 PCOS patients under the age of 40 years, who were diagnosed based on the Rotterdam criteria in Gürgan IVF clinic between 2005 and 2015. The study protocol was approved by the local ethics committee, and all patients included in the study provided informed consent. The patients were diagnosed with PCOS in accordance with the diagnostic criteria of the European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine Rotterdam Consensus Meeting 2003 (18). Based on this set of criteria, two of the following three criteria are necessary for confirming a diagnosis: -Anovulation or Oligoovulation -Biochemical or Clinical Hyperandr...

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“…Regarding the efficacy of treatment, it seems that there is no significant difference in fertilization, pregnancy and live birth rates as compared to controls, although a higher number of oocytes is usually recovered in PCOS [74]. In IVF/intracytoplasmic sperm injection (ICSI) cycles, obesity and PCOS were found to independently decrease oocyte size [75]. An increased miscarriage rate was found in a mixed population of obese women undergoing IVF/ICSI as compared to women with normal weight, while a tendency for a higher miscarriage rate was found in women with a BMI >25 kg/m 2 regardless of the mode of conception.…”

Section: In Vitro Fertilizationmentioning

confidence: 99%

Polycystic ovaries and obesity

Messinis

Messini

Anifandis

et al. 2015

Best Practice & Research Clinical Obstetrics & Gynaecol

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Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles

Cited by 97 publications

References 38 publications

Developmental capacity of in vitro–matured human oocytes retrieved from polycystic ovary syndrome ovaries containing no follicles larger than 6 mm

Developmental capacity of in vitro–matured human oocytes retrieved from polycystic ovary syndrome ovaries containing no follicles larger than 6 mm

Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome

Polycystic ovaries and obesity

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