Polycystic ovarian syndrome-associated cardiovascular complications: An overview of the association between the biochemical markers and potential strategies for their prevention and elimination

Nayaker, B.S.; Thomas, Sowmya; Ramachandran, Sandhiya; Loganathan, Swetha; Sundari, M. Shanmuga; Kundabala, M

doi:10.1016/j.dsx.2017.07.004

Cited by 10 publications

(4 citation statements)

References 168 publications

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“…PCOS is characterized by oligo‐ovulation or anovulation, hyperandrogenism and polycystic ovaries . In addition to reproductive abnormalities, PCOS is also associated with obesity, type 2 diabetes, hyperinsulinaemia, insulin resistance, lipid abnormalities and cardiovascular diseases . However, the pathogenesis and molecular defects in PCOS are not fully understood …”

Section: Introductionmentioning

confidence: 99%

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S100‐A9 protein in exosomes derived from follicular fluid promotes inflammation via activation of NF‐κB pathway in polycystic ovary syndrome

Huang

Chang

et al. 2019

J Cellular Molecular Medi

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Exosomes have recently emerged as key mediators of different physiological and pathological processes. However, there has been few report about proteomic analysis of exosomes derived from human follicular fluid and their association with the occurrence of PCOS. Herein, we used TMT‐tagged quantitative proteomic approach to identify proteomic profiles in exosomes derived from follicular fluid of PCOS patients and healthy controls. We identified 662 proteins in exosomes derived from human ovarian follicular fluid. Eighty‐six differently expressed proteins (P < .05) were found between PCOS and healthy women. The alterations in the proteomic profile were related to the inflammation process, reactive oxygen species metabolic process, cell migration and proliferation. Importantly, we observed that follicular fluid exosomes contain S100 calcium‐binding protein A9 (S100‐A9) protein. Exosome‐enriched S100‐A9 significantly enhanced inflammation and disrupted steroidogenesis via activation of nuclear factor kappa B (NF‐κB) signalling pathway. These data demonstrate that exosomal proteins are differentially expressed in follicular fluid during disease process, and some proteins may play important roles in the regulation of granulosa cell function. These results highlight the importance of exosomes as extracellular communicators in ovarian follicular development.

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Section: Introductionmentioning

confidence: 99%

“…diseases. 10,11 However, the pathogenesis and molecular defects in PCOS are not fully understood. 12 Follicular fluid (FF) provides an important microenvironment for follicular development and oocyte maturation.…”

mentioning

confidence: 99%

S100‐A9 protein in exosomes derived from follicular fluid promotes inflammation via activation of NF‐κB pathway in polycystic ovary syndrome

Huang

Chang

et al. 2019

J Cellular Molecular Medi

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“…In women with PCOS, the concentration of AGEs is increased, and it has a pathogenic significance in many complications. Reason for pathological changes of AGEs include activating oxidative stress and inflammation [29]. PCOS women have elevated serum/ovarian AGEs and ovarian RAGE women with PCOS have a systemic chronic inflammatory condition even at the ovarian level, as represented by elevated levels of serum/ovarian AGEs and increased expression of the pro-inflammatory RAGE in ovarian tissue [30].…”

Section: Discussionmentioning

confidence: 99%

Blood pressure in postmenopausal women with a history of polycystic ovary syndrome

Doroszewska

Milewicz

Mrozińska

et al. 2019

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Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder at reproductive age, affecting 6-10% of females in this group. The aetiology of this syndrome is not fully understood. Genetics, endocrinology factors, and the influence of the environment are possible causes of this syndrome. PCOS is characterised by menstrual disorders, hyperandrogenism, and abnormalities in ovarian morphology as well as metabolic disorders. PCOS increases the risk of overweight and obesity, diabetes, endometrial cancer, and cardiovascular diseases such as hypertension along with all its long-term consequences. There are limited studies about cardiovascular disorders, especially hypertension, in postmenopausal women with a history of PCOS. The presented paper is an attempt to briefly summarise literature data concerning the influence of this disease on the incidence of hypertension and blood pressure control in postmenopausal women. Women with PCOS more often present features of metabolic syndrome and have increased cardiovascular risk factors including hypertension. The prevalence of hypertension is 2.5 times higher than in corresponding healthy peers. Furthermore, hyperandrogenaemia is associated with elevated blood pressure independent of the patient's age, insulin resistance, obesity, and dyslipidaemia. In view of this, these patients should be thoroughly screened for hypertensive disorders and educated about the lifestyle modifications that could prevent hypertension later in life.

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“…Management of PCOS is limited to improve clinical manifestations, since the real etiology of the disorder is unclear [47]. While multiple cardiovascular risk factors such as obesity, dyslipidemia, hypertension, and DM are prevalent in PCOS, current therapeutic management of PCOS usually focuses firstly on the treatment of metabolic disturbances (anovulation, menstrual irregularity, and hirsutism) and secondly on the control of reproductive hormones or insulin levels [48]. Lifestyle modifications including increased exercise, dietary changes, and weight loss are appropriate first-line interventions for many women with PCOS [49].…”

Section: Conventional Management and Limitationsmentioning

confidence: 99%

Complementary Therapy with Traditional Chinese Medicine for Polycystic Ovarian Syndrome

Liao¹,

Hu²,

Hung³

2018

Debatable Topics in PCOS Patients

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Polycystic ovarian syndrome (PCOS) is a common, heterogeneous, complex, endocrinopathic condition that causes menstrual dysfunction and infertility in women. Traditional Chinese medicine (TCM) has been widely used for PCOS in Far-East countries for thousands of years. There are significant advantages in treating PCOS with TCM. This chapter aims to investigate the current developments in TCM therapy for PCOS.

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Polycystic ovarian syndrome-associated cardiovascular complications: An overview of the association between the biochemical markers and potential strategies for their prevention and elimination

Cited by 10 publications

References 168 publications

S100‐A9 protein in exosomes derived from follicular fluid promotes inflammation via activation of NF‐κB pathway in polycystic ovary syndrome

S100‐A9 protein in exosomes derived from follicular fluid promotes inflammation via activation of NF‐κB pathway in polycystic ovary syndrome

Blood pressure in postmenopausal women with a history of polycystic ovary syndrome

Complementary Therapy with Traditional Chinese Medicine for Polycystic Ovarian Syndrome

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