Polycystic ovarian syndrome: A review covering phytoconstituents for its outstrip management

Joshi, Monika; Shankar, Ravi; Pathak, Kamla; Yadav, Ramakant

doi:10.1016/j.prmcm.2021.100011

Cited by 7 publications

(15 citation statements)

References 112 publications

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“…Onychorrhexis, on the other hand, refers to the process in which nails split into lengthwise bridges ( 39 ). Although the precise explanation for this result is not entirely clear, a number of studies have found that elevated androgen levels in PCOS patients are associated with more severe cases of onycholysis and onychorrhexis ( 2 ).…”

Section: Methodsmentioning

confidence: 99%

“…A long-term intervention is required for PCOS treatment owing to the significant and severe adverse reactions of currently used drugs, which warrants the search for novel therapies for the chronic management of PCOS ( 50 ). For the treatment of PCOS, the use of plant-based medications, which have fewer potential negative side effects, is likely to become the most effective strategy ( 2 ) as shown in Figure 2 .…”

Section: Methodsmentioning

confidence: 99%

“…The Stein–Leventhal syndrome was the initial name for the condition that is now known as polycystic ovary syndrome (PCOS) ( 1 ). It is a harmful illness that predominantly affects females and is characterized by an enlargement of the ovaries that are filled with many tiny cysts that are actually immature follicles ( 2 ). Ovulation, menstrual abnormalities, infertility, and insulin resistance are all related to PCOS.…”

Section: Introductionmentioning

confidence: 99%

“…However, their chronic use is associated with the risk of endometrial cancer in women after menopause. This risk seems to increase as the dose and the length of use increase ( 2 ). Since ancient times, medicinal plants have had a great deal of potential for treatment and mitigation of acute and chronic diseases, and now, as a result of the research that has been conducted, new medicinal plants that are useful and advantageous are being uncovered ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

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Alternative treatment of polycystic ovary syndrome: pre-clinical and clinical basis for using plant-based drugs

Malik,

Saeed,

Saleem

et al. 2024

Front. Endocrinol.

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The most common cause of infertility and metabolic problems among women of reproductive age is polycystic ovary syndrome (PCOS), a multifaceted disorder. It is an endocrine disorder that occurs in approximately one in seven women. Among these PCOS patients, two thirds will not ovulate on a regular basis and seek treatment for ovulation induction. The symptoms vary in their severity, namely ovulation disorders, excessive androgen levels, or polycystic ovarian morphology. All these symptoms require a therapeutic approach. Many drugs are used to eradicate PCOS symptoms, like metformin, clomiphene citrate, spironolactone, and pioglitazone. Long-term treatment is required to achieve the desired outcome, which is often accompanied by significant adverse reactions. Some herbs and phytochemicals are equally effective for treating PCOS and produce minimal side effects. Recently, herbal products are gaining popularity due to their wide biological activities, safety, availability, and efficacy. The present review covers aetiology, current treatment, pathophysiology, and detailed pre-clinical and clinical studies on plants and phytochemicals that are proven to be useful for the treatment of symptoms associated with PCOS.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Alternative treatment of polycystic ovary syndrome: pre-clinical and clinical basis for using plant-based drugs

Malik,

Saeed,

Saleem

et al. 2024

Front. Endocrinol.

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“…Because of its versatile nature, RT is now a well-known constituent of more than 130 registered medicinal preparations (Chua, 2013). RT, also known as rutoside, QE-3rutinoside, and vitamin P, is a dietary polyphenolic bioflavonoid extracted from fruits, and many Chinese medical herbs, such as Fagopyrum tataricum (tartary buckwheat), Flos Sophorae (Huai Mi), and R. graveolens (Yun Xiang) various pharmacological activities, including antioxidant, antiallergenic, anti-inflammatory, anticarcinogenic, antiviral, and superoxide radical potential (Enogieru et al, 2018), antiapoptotic, cardioprotective, vasoprotective, antihyperlipidemic, nephroprotective, antihyperuricemic, neuroprotective, hepatoprotective, and anticancer properties have been reported for RT (Cai et al, 2020;Dong et al, 2021;Joshi et al, 2021).…”

Section: Ruta Graveolens (Inggu)mentioning

confidence: 99%

Neuroprotective activity of Indonesian traditional herbal medicine: A systematic review

Agil,

Kusumawati,

Muslikh

et al. 2023

J Appl Pharm Sci

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The brain requires good care for it regulates all systems and functions of the human body's organs. Good care can also prevent brain damage caused by the aging process and neurodegenerative diseases. Consuming herbs is one of the treatments for the brain. This study aims to provide an overview of the neuroprotective use of herbs in traditional Indonesian medicine. The method employed is a review of articles based on predetermined criteria. The plants were then reselected based on the plants used for the central nervous system (CNS) in the Cabe Puyang Manuscript. Cabe Puyang is a manuscript that describes the health benefits of various medicinal herbs. According to the criteria, 31 herbs acting as neuroprotective agents in Indonesia were discovered. The herbs were reselected based on the herbs used in the Cabe Puyang Manuscript for the CNS. Twelve herbs have been included in Indonesia's traditional medicine system for use as neuroprotectors. These herbs are Zingiber officinale, Centella asiatica, Allium sativum, Andrographis paniculata, Piper nigrum, Coriandrum sativum, Piper retrofractum, Moringa oleifera, Ocimum sanctum, Kaempferia galangal, Ruta graveolens, and Acorus calamus. The Cabe Puyang Manuscript mentioned all of the selected herbs used as neuroprotectors in the Indonesian system of medicine. They all demonstrated a strong antioxidative and antiinflammatory action in brain tissues. Both actions are manifestations of neurodegenerative pathologies.

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Protective effect of rutin on acrylamide induced ovarian inflammation, oxidative stress, DNA damage, and hormonal changes: Based on in silico and in vivo study

Gupta,

Shrivastava,

Kumar

et al. 2024

J Biochem & Molecular Tox

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Acrylamide (AA) is a carcinogenic compound that affects people due to its frequent use in laboratories and industry as well as the high‐temperature cooking of foods with high hydrocarbon content. AA is known to cause severe reproductive abnormalities. The main aim of this study is to evaluate the protective effect of rutin (RU), a phytoactive compound, against AA‐induced reproductive toxicity in female rats. Initially, rats were exposed to AA (40 mg/kg for 10 days). Therapy of RU was given after AA intoxication consecutively for 3 days. After 24 h of the last treatment, all the animals were sacrificed. The study evaluated reproductive hormones, oxidative stress markers, membrane‐bound enzymes, DNA damage, histological findings, and an in silico approach to determine the protective efficacy of RU. The results indicated that RU significantly protected against inflammation, oxidative stress, and DNA damage induced by AA, likely due to its antioxidant properties.

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Polycystic ovarian syndrome: A review covering phytoconstituents for its outstrip management

Cited by 7 publications

References 112 publications

Alternative treatment of polycystic ovary syndrome: pre-clinical and clinical basis for using plant-based drugs

Alternative treatment of polycystic ovary syndrome: pre-clinical and clinical basis for using plant-based drugs

Neuroprotective activity of Indonesian traditional herbal medicine: A systematic review

Protective effect of rutin on acrylamide induced ovarian inflammation, oxidative stress, DNA damage, and hormonal changes: Based on in silico and in vivo study

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