Polycystic Ovarian Disease — Current Concepts

Biggs, J. S. G.

doi:10.1111/j.1479-828x.1981.tb00120.x

Cited by 8 publications

(3 citation statements)

References 60 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well known that a cardinal disturbance of PCOS is elevated concentrations of LH (Yen, 1980;Biggs, 1981). LH subsequently stimulates the follicular theca intema cells to produce androstenedione (Biggs and Thomas, 1981).…”

Section: Discussionmentioning

confidence: 99%

Endocrinology: Iminunohistochemical study of steroidogenesis and cell proliferation in polycystic ovarian syndrome

et al. 1996

View full text Add to dashboard Cite

We evaluated the immunolocalization of the steroidogenic enzymes involved in the production of ovarian steroids, including the cholesterol side-chain cleavage enzyme (P450scc), 3beta-hydroxysteroid dehydrogenase (HSD), 17alpha-hydroxylase (P450c17) and aromatase (P450arom), oestrogen receptor (ER) and androgen receptor (AR), a steroidogenic transcription factor. Ad4-binding protein (Ad4BP) and a cell cycle-related nuclear antigen, Ki67, in five patients with polycystic ovarian syndrome (PCOS). Results were compared with those from normal cycling human ovaries to study in situ ovarian steroidogenesis and cell proliferation in polycystic ovaries (PCO). We classifed the follicles morphologically according to the development of granulosa types: type A, more than four layers (n = 7); type B, one to three layers (n = 11); and type C, theca interna cells only (n = 21). ER and P450arom were not observed in any of the follicles examined. In type A follicles, P450scc, 3beta-HSD, P450c17, AR and Ad4BP were observed in theca cells in all seven follicles examined, but the granulosa cells were positive only for Ad4BP (4/7) and AR (7/7). These immunohistolocalization patterns resembled those in non-selected antral follicles of normally cycling human ovaries. In theca cells from types B and C follicles, follicles positive for the steroidogenic enzymes, AR and Ad4BP were decreased in number. There were no significant differences between types A and B PCO follicles in the Ki67 labelling index of granulosa or theca cells, and between PCO and antral follicles from normally cycling human ovaries. Data demonstrate that the follicles of PCO are by no means atretic and are actively involved in both steroidogenesis and cell proliferation. The absence of ER and aromatase expression in the granulosa cells of PCO may be important in abnormal follicular development in patients with PCOS.

show abstract

Section: Discussionmentioning

confidence: 99%

Endocrinology: Iminunohistochemical study of steroidogenesis and cell proliferation in polycystic ovarian syndrome

et al. 1996

View full text Add to dashboard Cite

show abstract

“…smoking, lack of vitamins and proteins and essential • mineral that may leads to malnutrition in teenage females and in long terms it is not a sign of good and healthy lifestyle(J.s.G. Biggs et. at.…”

Section: Causes Of Ovarian Cancer Pcod: •mentioning

confidence: 99%

An Assessment on Cause, Symptoms & Treatment for Ovarian Cancer

Arora¹

2021

Biosc Biotech Res Comm

View full text Add to dashboard Cite

As technology is increasing day by day, humans are getting affected by the side effects of these technology. Earlier the manual hard work was done by most of the people but now a day people are facing lot of health issues due to getting habitual of advance automatic devices. No doubts, smart gadgets reduce the human effort in daily life but, it is not wrong to say that being habitual of everything is bad even for health as well. In this paper some of causes, symptoms and treatments of ovarian cancer has been discussed in order to spread awareness regarding prevention and precautions that one should take. An assessment has been done on randomly selected women at nearby metro station by asking them few questions.For future perspective, spreading knowledge and awareness regarding women health and ovarian cancer may be proven as a big step towards healthy life.

show abstract

“…Yet in viewing ovaries, the screening for capsular thickening, subcapsular follicular cysts and hyperplasia of the theca interna are also advised to be viewed (17). The ovary report should also highlight ovarian volume and antral follicle counts (18).…”

Section: Introductionmentioning

confidence: 99%